Abstract:
:Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into adulthood. The brain is a critical target for developmental endocrine disruption, resulting in altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous system function, and fundamental changes in behaviors such as learning, memory, and social interactions. Human cohort studies reveal correlations between maternal/fetal exposure to endocrine disruptors and incidence of neurodevelopmental disorders. Here, we summarize the major literature findings of endocrine disruption of neurodevelopment and concomitant changes in behavior by four major endocrine disruptor classes:bisphenol A, polychlorinated biphenyls, organophosphates, and polybrominated diphenyl ethers. We specifically review studies of gestational and/or lactational exposure to understand the effects of early life exposure to these compounds and summarize animal studies that help explain human correlative data.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Nesan D,Kurrasch DMdoi
10.1146/annurev-physiol-021119-034555subject
Has Abstractpub_date
2020-02-10 00:00:00pages
177-202eissn
0066-4278issn
1545-1585journal_volume
82pub_type
杂志文章,评审abstract::Reabsorption of amino acids, similar to that of glucose, is a major task of the proximal kidney tubule. Various amino acids are actively transported across the luminal brush border membrane into proximal tubule epithelial cells, most of which by cotransport. An important player is the newly identified cotransporter (s...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.67.031103.153949
更新日期:2005-01-01 00:00:00
abstract::The ability of the myocardium to successfully compensate for and adapt to environmental stress ultimately determines whether the heart will decompensate and fail or maintain preserved function. Despite the importance of the myocardial response to environmental stress, very little is known with respect to the biochemic...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.65.092101.142249
更新日期:2003-01-01 00:00:00
abstract::Calcium and sodium absorption by the kidney normally proceed in parallel. However, a number of physiological, pharmacological, pathological, and genetic conditions dissociate this relation. In each instance, the dissociation can be traced to the distal convoluted tubule, where calcium and sodium transport are inversel...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.60.1.179
更新日期:1998-01-01 00:00:00
abstract::Evidence indicates that PDGF is a major cytokine that impacts on the biology of renal cells and the pathogenesis of renal disease. The biologic effects of PDGF on cells and tissue, whether contraction, proliferation, matrix expansion, or cell migration, can result in beneficial or injurious consequences depending on t...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.57.030195.001501
更新日期:1995-01-01 00:00:00
abstract::Distinct potassium, anion, and calcium channels in the plasma membrane and vacuolar membrane of plant cells have been identified and characterized by patch clamping. Primarily owing to advances in Arabidopsis genetics and genomics, and yeast functional complementation, many of the corresponding genes have been identif...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.010908.163204
更新日期:2009-01-01 00:00:00
abstract::The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the regulation of epithelial ion transport. This kinase is very rapidly regulated at the transcriptional level as well as via posttranslational modifications involving phosphorylation by the MAP or PI-3 kinase pathways and/or ubiquitylation. Altho...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.68.040104.131654
更新日期:2006-01-01 00:00:00
abstract::The pituitary gonadotropic hormones, FSH (follicle-stimulating hormone) and LH (lutienizing hormone) play important roles in regulating both the steroidogenic and gametogenic functions of the ovary. The secretion of pituitary gonadotropins is controlled, in turn, by feedback influences, both negative and positive, ex...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.42.030180.000443
更新日期:1980-01-01 00:00:00
abstract::Current information indicates that the mammalian kidney is a significant site of EGF synthesis, second only to the salivary gland in the rodent and probably exceeding most other tissues in the human species. The prepro EGF mRNA is localized to the cells of the TALH and the DCT. The EGF mRNA transcript in kidney is sim...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.51.030189.000435
更新日期:1989-01-01 00:00:00
abstract::It is apparent that proton transport plays an important role in many essential hepatocyte functions. Important unanswered issues include the location of the H+-ATPase and its role in hepatic functions, the regulators of Na+-H+ exchange, the exact role of Na+-H+ exchange in bile formation and in hepatic regeneration, a...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.49.030187.000441
更新日期:1987-01-01 00:00:00
abstract::The most striking characteristics of the myenteric plexus are the heterogeneity of its neuronal populations and the complexity of its organization. Myenteric neurons greatly differ in their morphological characteristics, projection patterns, and topographical arrangement within the ganglia. The discovery of histochemi...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.50.030188.000501
更新日期:1988-01-01 00:00:00
abstract::Tremendous progress has been made in elucidating numerous critical aspects of estrogen signaling. New tools and techniques have enabled detailed molecular analysis of components that direct estrogen responses. At the other end of the spectrum, generation of a multiplicity of transgenic animals has allowed analysis of ...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.67.040403.115914
更新日期:2005-01-01 00:00:00
abstract::Helicobacter pylori is a neutralophilic, gram-negative, ureolytic organism that is able to colonize the human stomach but does not survive in a defined medium with a pH <4.0 unless urea is present. In order to live in the gastric environment, it has developed a repertoire of acid resistance mechanisms that can be clas...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.65.092101.142156
更新日期:2003-01-01 00:00:00
abstract::Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for its role in contractile activation. However, in recent years the critical role of Ca in other myocyte processes has become increasingly clear. This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophys...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.70.113006.100455
更新日期:2008-01-01 00:00:00
abstract::The life of a human lung can be subdivided into five distinct phases: embryonic, pseudoglandular, canalicular, saccular, and alveolar. The embryonic period, during which the lung primordium is laid down as a diverticulum of the foregut, lasts for about seven weeks. From the 5th to the 17th week the lung looks much lik...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.46.030184.003153
更新日期:1984-01-01 00:00:00
abstract::A precise description of the involvement of G proteins in regulation of the cardiovascular system is not possible at the present time although it is clear that they do have important regulatory roles. The cardiovascular system is composed of a variety of cell types, which are subject to control by several different ho...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.51.030189.001305
更新日期:1989-01-01 00:00:00
abstract::Low oxygen (O2) levels are a naturally occurring feature of embryonic development, adult physiology, and diseases such as those of the cardiovascular system. Although many responses to O2 deprivation are mediated by hypoxia-inducible factors (HIFs), researchers are finding a growing number of HIF-independent pathways ...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.70.113006.100526
更新日期:2008-01-01 00:00:00
abstract::This review focuses on the role of the venous valves in the genesis of thrombus formation in venous thromboembolic disease (VTE). Clinical VTE and the evidence for the valvular origin of venous thrombosis are reviewed. Virchow's triad is then used as a framework for discussion to approach the question posed regarding ...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev-physiol-012110-142305
更新日期:2011-01-01 00:00:00
abstract::The hedgehog (Hh) signaling pathway plays several diverse regulatory and patterning roles during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In the embryo, fetus, and adult, intestinal Hh signaling is paracrine: Hh ligands are expressed in the endodermally derived epithelium, ...
journal_title:Annual review of physiology
pub_type: 杂志文章
doi:10.1146/annurev-physiol-031620-094324
更新日期:2020-10-09 00:00:00
abstract::A largely unilamellar epithelial layer lines body cavities and organ ducts such as the digestive tract and kidney tubules. This polarized epithelium is composed of biochemically and functionally separate apical and basolateral surfaces. The epidermal growth factor receptor (EGFR) signaling pathway is a critical regula...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev-physiol-021113-170406
更新日期:2014-01-01 00:00:00
abstract::Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made ...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.60.1.385
更新日期:1998-01-01 00:00:00
abstract::The question of respiratory factors limiting exercise has been examined in terms of possible limitations arising from the function of gas exchange, the respiratory mechanics, the energetics of the respiratory muscles, or the development of respiratory muscle fatigue. Exercise capacity is curtailed in the presence of m...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.45.030183.002255
更新日期:1983-01-01 00:00:00
abstract::The ability of fishes, amphibians, and reptiles to survive extremes of oxygen availability derives from a core triad of adaptations: profound metabolic suppression, tolerance of ionic and pH disturbances, and mechanisms for avoiding free-radical injury during reoxygenation. For long-term anoxic survival, enhanced stor...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.69.031905.162529
更新日期:2007-01-01 00:00:00
abstract::Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including i...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev-physiol-021113-170252
更新日期:2014-01-01 00:00:00
abstract::In addition to the well established action of PTH in proximal tubules and of AVP in collecting tubules, polypeptide hormones were recently shown to regulate transport properties in other tubular portions. Although still scarce, such physiological studies using isolated perfused tubules demonstrated hormonal effects in...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.43.030181.003033
更新日期:1981-01-01 00:00:00
abstract::Intercellular channels present in gap junctions allow cells to share small molecules and thus coordinate a wide range of behaviors. Remarkably, although junctions provide similar functions in all multicellular organisms, vertebrates and invertebrates use unrelated gene families to encode these channels. The recent ide...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.61.1.283
更新日期:1999-01-01 00:00:00
abstract::Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism. In addition, BCAAs and various catabolic products act as sig...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev-physiol-020518-114455
更新日期:2019-02-10 00:00:00
abstract::Three families of growth factors/hormones have major effects on the differentiation of skeletal muscle cells. Two (FGF and TGF-beta) are potent inhibitors, and the third (IGF) exhibits a biphasic stimulatory action (but is not inhibitory even at high concentrations). All of these affect the expression of myogenin, one...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.53.030191.001221
更新日期:1991-01-01 00:00:00
abstract::One of the central questions in neurobiology is how experience modifies neural function, and how changes in the nervous system permit an animal to adapt its behavior to a changing environment. Learning and adaptation to a host of different environmental stimuli exemplify processes we know must alter the nervous system...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.66.032102.112534
更新日期:2004-01-01 00:00:00
abstract::Multiple organic anion transporters in the proximal tubule of the kidney are involved in the secretion of drugs, toxic compounds, and their metabolites. Many of these compounds are potentially hazardous on accumulation, and it is therefore not surprising that the proximal tubule is also an important target for toxicit...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.64.081501.155913
更新日期:2002-01-01 00:00:00
abstract::Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment. Three broad pathways control polar...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev-physiol-022516-034339
更新日期:2017-02-10 00:00:00