Abstract:
:This review focuses on the role of the venous valves in the genesis of thrombus formation in venous thromboembolic disease (VTE). Clinical VTE and the evidence for the valvular origin of venous thrombosis are reviewed. Virchow's triad is then used as a framework for discussion to approach the question posed regarding the link between venous valvular stasis-associated hypoxia and thrombosis. Thus, the effects of blood flow stasis, hypercoagulability of blood, and the characteristics of the vessel wall within the venous valvular sinus are assessed in turn.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Bovill EG,van der Vliet Adoi
10.1146/annurev-physiol-012110-142305subject
Has Abstractpub_date
2011-01-01 00:00:00pages
527-45eissn
0066-4278issn
1545-1585journal_volume
73pub_type
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