Abstract:
:Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made In particular, a site in the ventrolateral medulla, the preBötzinger Complex, is hypothesized to contain neuronal circuits generating respiratory rhythm. Lesions or disruption of synaptic transmission within the preBötzinger Complex, either in vivo or in vitro, can abolish respiratory activity. Furthermore, the persistence of respiratory rhythm following interference with postsynaptic inhibition and the subsequent discovery of neurons with endogenous bursting properties within the preBötzinger Complex have led to the hypothesis that rhythmogenesis results from synchronized activity of pacemaker or group-pacemaker neurons.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Rekling JC,Feldman JLdoi
10.1146/annurev.physiol.60.1.385subject
Has Abstractpub_date
1998-01-01 00:00:00pages
385-405eissn
0066-4278issn
1545-1585journal_volume
60pub_type
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