Abstract:
:Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide range of physiological functions, including cardiac and neuronal pacemaker activity, the setting of resting potentials, input conductance and length constants, and dendritic integration. The hyperpolarization-activated, cation nonselective (HCN) gene family encodes the channels that underlie Ih. Here we review the relation between the biophysical properties of recombinant HCN channels and the pattern of HCN mRNA expression with the properties of native Ih in neurons and cardiac muscle. Moreover, we consider selected examples of the expanding physiological functions of Ih with a view toward understanding how the properties of HCN channels contribute to these diverse functional roles.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Robinson RB,Siegelbaum SAdoi
10.1146/annurev.physiol.65.092101.142734subject
Has Abstractpub_date
2003-01-01 00:00:00pages
453-80eissn
0066-4278issn
1545-1585pii
092101.142734journal_volume
65pub_type
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journal_title:Annual review of physiology
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