Hyperpolarization-activated cation currents: from molecules to physiological function.

Abstract:

:Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide range of physiological functions, including cardiac and neuronal pacemaker activity, the setting of resting potentials, input conductance and length constants, and dendritic integration. The hyperpolarization-activated, cation nonselective (HCN) gene family encodes the channels that underlie Ih. Here we review the relation between the biophysical properties of recombinant HCN channels and the pattern of HCN mRNA expression with the properties of native Ih in neurons and cardiac muscle. Moreover, we consider selected examples of the expanding physiological functions of Ih with a view toward understanding how the properties of HCN channels contribute to these diverse functional roles.

journal_name

Annu Rev Physiol

authors

Robinson RB,Siegelbaum SA

doi

10.1146/annurev.physiol.65.092101.142734

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

453-80

eissn

0066-4278

issn

1545-1585

pii

092101.142734

journal_volume

65

pub_type

杂志文章,评审
  • The gastric biology of Helicobacter pylori.

    abstract::Helicobacter pylori is a neutralophilic, gram-negative, ureolytic organism that is able to colonize the human stomach but does not survive in a defined medium with a pH <4.0 unless urea is present. In order to live in the gastric environment, it has developed a repertoire of acid resistance mechanisms that can be clas...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.65.092101.142156

    authors: Sachs G,Weeks DL,Melchers K,Scott DR

    更新日期:2003-01-01 00:00:00

  • Lessons in estrogen biology from knockout and transgenic animals.

    abstract::Tremendous progress has been made in elucidating numerous critical aspects of estrogen signaling. New tools and techniques have enabled detailed molecular analysis of components that direct estrogen responses. At the other end of the spectrum, generation of a multiplicity of transgenic animals has allowed analysis of ...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.67.040403.115914

    authors: Hewitt SC,Harrell JC,Korach KS

    更新日期:2005-01-01 00:00:00

  • Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.

    abstract::Multiple mechanisms contribute to the regulation of G protein-coupled receptors and their transmembrane signaling. Post-translational modifications of the receptors, such as phosphorylation, and changes in receptor gene expression can occur in either a strictly agonist-dependent fashion or through second messenger-med...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.53.030191.002433

    authors: Collins S,Caron MG,Lefkowitz RJ

    更新日期:1991-01-01 00:00:00

  • Hedgehog Signaling in Intestinal Development and Homeostasis.

    abstract::The hedgehog (Hh) signaling pathway plays several diverse regulatory and patterning roles during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In the embryo, fetus, and adult, intestinal Hh signaling is paracrine: Hh ligands are expressed in the endodermally derived epithelium, ...

    journal_title:Annual review of physiology

    pub_type: 杂志文章

    doi:10.1146/annurev-physiol-031620-094324

    authors: Walton KD,Gumucio DL

    更新日期:2020-10-09 00:00:00

  • The insulin-like growth factors.

    abstract::The recent availability of reagents to study the IGFs, their receptors, and binding proteins has led to an explosive growth in the study of IGF physiology. However, most studies to date have been descriptive, and studies delineating mechanisms of action are limited. It is apparent that most organ systems synthesize se...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.55.030193.001023

    authors: Cohick WS,Clemmons DR

    更新日期:1993-01-01 00:00:00

  • Mechanisms underlying the cost of living in animals.

    abstract::The cost of living can be measured as an animal's metabolic rate. Basal metabolic rate (BMR) is factorially related to other metabolic rates. Analysis of BMR variation suggests that metabolism is a series of linked processes varying in unison. Membrane processes, such as maintenance of ion gradients, are important cos...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.62.1.207

    authors: Hulbert AJ,Else PL

    更新日期:2000-01-01 00:00:00

  • Cell volume regulation in the nephron.

    abstract::Nearly every cell in the kidney can volume regulate in response to a hypertonic challenge. Some are able to respond immediately to hyperosmotic media by a RVI. Other cells require stimulation prior to exposure to hyperosmolarity to demonstrate RVI. An increase of intracellular osmolytes during RVI usually occurs by an...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.52.030190.003553

    authors: Montrose-Rafizadeh C,Guggino WB

    更新日期:1990-01-01 00:00:00

  • Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability.

    abstract::The ability of fishes, amphibians, and reptiles to survive extremes of oxygen availability derives from a core triad of adaptations: profound metabolic suppression, tolerance of ionic and pH disturbances, and mechanisms for avoiding free-radical injury during reoxygenation. For long-term anoxic survival, enhanced stor...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.69.031905.162529

    authors: Bickler PE,Buck LT

    更新日期:2007-01-01 00:00:00

  • Genetic diseases and gene knockouts reveal diverse connexin functions.

    abstract::Intercellular channels present in gap junctions allow cells to share small molecules and thus coordinate a wide range of behaviors. Remarkably, although junctions provide similar functions in all multicellular organisms, vertebrates and invertebrates use unrelated gene families to encode these channels. The recent ide...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.61.1.283

    authors: White TW,Paul DL

    更新日期:1999-01-01 00:00:00

  • Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications.

    abstract::NaCl absorption along the nephron is regulated not just by humoral factors but also by factors that do not circulate or act on the cells where they are produced. Generally, nitric oxide (NO) inhibits NaCl absorption along the nephron. However, the effects of NO in the proximal tubule are controversial and may be bipha...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-physiol-012110-142247

    authors: Garvin JL,Herrera M,Ortiz PA

    更新日期:2011-01-01 00:00:00

  • Upper limits to mass-specific metabolic rates.

    abstract::An intriguing aspect of animal diversity is the wide range of maximal mass-specific metabolic rates attainable by various species. Metabolic ceilings vary with respect to whether hypermetabolic states involve relatively short bouts of burst or aerobic exercise, or long-term physical activity wherein time-averaged rate...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.58.030196.003055

    authors: Suarez RK

    更新日期:1996-01-01 00:00:00

  • Epidermal growth factor and the kidney.

    abstract::Current information indicates that the mammalian kidney is a significant site of EGF synthesis, second only to the salivary gland in the rodent and probably exceeding most other tissues in the human species. The prepro EGF mRNA is localized to the cells of the TALH and the DCT. The EGF mRNA transcript in kidney is sim...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.51.030189.000435

    authors: Fisher DA,Salido EC,Barajas L

    更新日期:1989-01-01 00:00:00

  • Novel renal amino acid transporters.

    abstract::Reabsorption of amino acids, similar to that of glucose, is a major task of the proximal kidney tubule. Various amino acids are actively transported across the luminal brush border membrane into proximal tubule epithelial cells, most of which by cotransport. An important player is the newly identified cotransporter (s...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.67.031103.153949

    authors: Verrey F,Ristic Z,Romeo E,Ramadan T,Makrides V,Dave MH,Wagner CA,Camargo SM

    更新日期:2005-01-01 00:00:00

  • Antifreeze proteins of teleost fishes.

    abstract::Marine teleosts at high latitudes can encounter ice-laden seawater that is approximately 1 degrees C colder than the colligative freezing point of their body fluids. They avoid freezing by producing small antifreeze proteins (AFPs) that adsorb to ice and halt its growth, thereby producing an additional non-colligative...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.63.1.359

    authors: Fletcher GL,Hew CL,Davies PL

    更新日期:2001-01-01 00:00:00

  • Biological functions of angiotensin and its receptors.

    abstract::Angiotensin receptors are present in a number of organs and systems including heart, kidney, gonad, and placenta; pituitary and adrenal glands; the peripheral vessels, and the central nervous system. This octapeptide exerts diverse effects that include induction of cell hypertrophy and/or hyperplasia and a stimulation...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.59.1.395

    authors: Matsusaka T,Ichikawa I

    更新日期:1997-01-01 00:00:00

  • Renal genetic disorders related to K+ and Mg2+.

    abstract::The recent knowledge of the renal epithelial transport systems has exploded with the identification, cloning, and characterization of a large number of membrane transport proteins. The fundamental aspects of these transporters are beginning to emerge at the molecular level and are summarized in the accompanying contri...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.64.081501.160000

    authors: Warnock DG

    更新日期:2002-01-01 00:00:00

  • Calcium cycling and signaling in cardiac myocytes.

    abstract::Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for its role in contractile activation. However, in recent years the critical role of Ca in other myocyte processes has become increasingly clear. This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophys...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.70.113006.100455

    authors: Bers DM

    更新日期:2008-01-01 00:00:00

  • Living in the now: physiological mechanisms to tolerate a rapidly changing environment.

    abstract::Rising atmospheric carbon dioxide has resulted in scientific projections of changes in global temperatures, climate in general, and surface seawater chemistry. Although the consequences to ecosystems and communities of metazoans are only beginning to be revealed, a key to forecasting expected changes in animal communi...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-physiol-021909-135900

    authors: Hofmann GE,Todgham AE

    更新日期:2010-01-01 00:00:00

  • Molecular aspects of hormone action in ovarian follicular development, ovulation, and luteinization.

    abstract::As stated earlier, the mammalian ovary maintains the continuous development of follicles, but only a few are selected to ovulate and form corpora lutea. These processes are regulated primarily by the gonadotropins and involve specific, sequential changes in the function of theca cells and granulosa cells. Data from re...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.50.030188.002301

    authors: Richards JS,Hedin L

    更新日期:1988-01-01 00:00:00

  • Respiratory factors limiting exercise.

    abstract::The question of respiratory factors limiting exercise has been examined in terms of possible limitations arising from the function of gas exchange, the respiratory mechanics, the energetics of the respiratory muscles, or the development of respiratory muscle fatigue. Exercise capacity is curtailed in the presence of m...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.45.030183.002255

    authors: Bye PT,Farkas GA,Roussos C

    更新日期:1983-01-01 00:00:00

  • Pulling the cart and enjoying the ride.

    abstract::I was pleased to receive the invitation to write this prefactory chapter. In doing so, I join a number of physiologists whose work and writings I have often admired. There are two aspects of my experience in physiology that I discuss here. The first concerns my own research accomplishments. The second is my role in de...

    journal_title:Annual review of physiology

    pub_type: 传,历史文章,杂志文章

    doi:10.1146/annurev.physiol.61.1.1

    authors: Hunt CC

    更新日期:1999-01-01 00:00:00

  • Microglia in Physiology and Disease.

    abstract::As the immune-competent cells of the brain, microglia play an increasingly important role in maintaining normal brain function. They invade the brain early in development, transform into a highly ramified phenotype, and constantly screen their environment. Microglia are activated by any type of pathologic event or cha...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-physiol-022516-034406

    authors: Wolf SA,Boddeke HW,Kettenmann H

    更新日期:2017-02-10 00:00:00

  • Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse.

    abstract::One of the central questions in neurobiology is how experience modifies neural function, and how changes in the nervous system permit an animal to adapt its behavior to a changing environment. Learning and adaptation to a host of different environmental stimuli exemplify processes we know must alter the nervous system...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.66.032102.112534

    authors: Kauer JA

    更新日期:2004-01-01 00:00:00

  • Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior.

    abstract::Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into adulthood. The brain is a critical target for developmental ...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-physiol-021119-034555

    authors: Nesan D,Kurrasch DM

    更新日期:2020-02-10 00:00:00

  • Interpreting the BOLD signal.

    abstract::The development of functional magnetic resonance imaging (fMRI) has brought together a broad community of scientists interested in measuring the neural basis of the human mind. Because fMRI signals are an indirect measure of neural activity, interpreting these signals to make deductions about the nervous system requir...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.physiol.66.082602.092845

    authors: Logothetis NK,Wandell BA

    更新日期:2004-01-01 00:00:00

  • Morphogenesis of the lung: control of embryonic and fetal branching.

    abstract::Lung development differs in the embryo and fetus with regard to branching pattern and organization of the epithelial cells. The surrounding mesodermal component, the capsule, has long been known to play a role in branching. As a result of recent analyses of distribution of components of the extracellular matrix couple...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.58.030196.000521

    authors: Hilfer SR

    更新日期:1996-01-01 00:00:00

  • Proton transport by hepatocyte organelles and isolated membrane vesicles.

    abstract::It is apparent that proton transport plays an important role in many essential hepatocyte functions. Important unanswered issues include the location of the H+-ATPase and its role in hepatic functions, the regulators of Na+-H+ exchange, the exact role of Na+-H+ exchange in bile formation and in hepatic regeneration, a...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.49.030187.000441

    authors: Scharschmidt BF,Van Dyke RW

    更新日期:1987-01-01 00:00:00

  • Current models of steroid hormone action: a critique.

    abstract::In this review, we have traced the path of estradiol from its entry into the cell to the time of its release from the receptor. We feel that all of the current models are limited in one respect or another. We have examined most critically those currently most in vogue. The entry of estradiol into the cell is widely as...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.38.030176.002233

    authors: Gorski J,Gannon F

    更新日期:1976-01-01 00:00:00

  • A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.

    abstract::Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including i...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-physiol-021113-170252

    authors: Kajimura S,Saito M

    更新日期:2014-01-01 00:00:00

  • Myocardial nucleotide transport.

    abstract::A thorough consideration of the evidence for striated muscle cell transmembrane nucleotide movement provides only equivocal support for adenine nucleotide specific translocation across cell membranes. It is obvious that nucleotide-derived adenosine is taken up into cells in preference to free adenosine, and it is impo...

    journal_title:Annual review of physiology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ph.47.030185.003133

    authors: Rovetto MJ

    更新日期:1985-01-01 00:00:00