Abstract:
:The past three years have seen remarkable progress in research on the molecular basis of inward rectification, with significant implications for basic understanding and pharmacological manipulation of cellular excitability. Expression cloning of the first inward rectifier K channel (Kir) genes provided the necessary break-through that has led to isolation of a family of related clones encoding channels with the essential functional properties of classical inward rectifiers, ATP-sensitive K channels, and muscarinic receptor-activated K channels. High-level expression of cloned channels led to the discovery that classical inward so-called anomalous rectification is caused by voltage-dependent block of the channel by polyamines and Mg2+ ions, and it is now clear that a similar mechanism results in inward rectification of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate receptor channels. Knowledge of the primary structures of Kir channels and the ability to mutate them also has led to the determination of many of the structural requirements of inward rectification.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Nichols CG,Lopatin ANdoi
10.1146/annurev.physiol.59.1.171subject
Has Abstractpub_date
1997-01-01 00:00:00pages
171-91eissn
0066-4278issn
1545-1585journal_volume
59pub_type
杂志文章,评审abstract::Congestive heart failure is associated with ventricular hypertrophy and dilatation, increased circulating catecholamines, and peripheral vasoconstriction. The extent to which these changes occur, whether they are a favorable "compensatory mechanism" or contribute to cardiocirculatory dysfunction, depends on the cause ...
journal_title:Annual review of physiology
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journal_title:Annual review of physiology
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更新日期:1997-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.68.040104.131654
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.70.113006.100455
更新日期:2008-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.50.030188.002301
更新日期:1988-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:1995-01-01 00:00:00
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更新日期:1999-01-01 00:00:00
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abstract::Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism. In addition, BCAAs and various catabolic products act as sig...
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更新日期:2019-02-10 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 传,历史文章,杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00