Abstract:
:The increasing prevalence of obesity worldwide has imparted renewed impetus to the study of the mechanisms of appetite regulation. Digestion and nutrient absorption take place in the gastrointestinal (GI) tract, whereas food intake is controlled by neuronal circuits in the central nervous system. The need for gut-brain cross talk is therefore clear. It is now recognized that hormones released into the circulation from the GI tract in response to nutritional stimuli form a key component of this gut-brain axis. Peptides such as glucagon-like peptide-1, oxyntomodulin, pancreatic polypeptide, and peptide YY3-36 reduce food intake in both animal models and in humans. Physiologically, such peptides are thought to act as satiety signals and meal terminators. Here, we review the current state of the field of the effects of gut hormone action on appetite control.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Chaudhri OB,Salem V,Murphy KG,Bloom SRdoi
10.1146/annurev.physiol.70.113006.100506subject
Has Abstractpub_date
2008-01-01 00:00:00pages
239-55eissn
0066-4278issn
1545-1585journal_volume
70pub_type
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