Abstract:
:The mammalian liver is one of the most regenerative tissues in the body, capable of fully recovering mass and function after a variety of injuries. This factor alone makes the liver unusual among mammalian tissues, but even more atypical is the widely held notion that the method of repair depends on the manner of injury. Specifically, the liver is believed to regenerate via replication of existing cells under certain conditions and via differentiation from specialized cells--so-called facultative stem cells--under others. Nevertheless, despite the liver's dramatic and unique regenerative response, the cellular and molecular features of liver homeostasis and regeneration are only now starting to come into relief. This review provides an overview of normal liver function and development and focuses on the evidence for and against various models of liver homeostasis and regeneration.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Stanger BZdoi
10.1146/annurev-physiol-021113-170255subject
Has Abstractpub_date
2015-01-01 00:00:00pages
179-200eissn
0066-4278issn
1545-1585journal_volume
77pub_type
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journal_title:Annual review of physiology
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