Abstract:
:Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for its role in contractile activation. However, in recent years the critical role of Ca in other myocyte processes has become increasingly clear. This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophysiology (including action potentials and arrhythmias), excitation-contraction coupling, modulation of contractile function, energy supply-demand balance (including mitochondrial function), cell death, and transcription regulation. Importantly, although such diverse Ca-dependent regulations occur simultaneously in a cell, the cell can distinguish distinct signals by local Ca or protein complexes and differential Ca signal integration.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Bers DMdoi
10.1146/annurev.physiol.70.113006.100455subject
Has Abstractpub_date
2008-01-01 00:00:00pages
23-49eissn
0066-4278issn
1545-1585journal_volume
70pub_type
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