Abstract:
:Despite continuous interest in cardiac hypertrophy, our knowledge of its molecular aspects is still elementary. Recently, however, several advancements of particular interest have been made: (a) Nuclei of muscle and nonmuscle cells have been separated, allowing for the first time the study of nuclear activity in specified cells (18). (b) Cardiac growth induced by pressure-overload (72) or by hormone treatment (26) has been shown to lead to myosin of altered ATPase, and strong evidence suggests that new species of myosin molecules thus appear. (c) The basis for assessment of protein synthesis and degradation has been established (46, 48). (d) Methods are being developed to supplement radioautography in evaluating cell proliferation (42, 59, 69). (e) In spontaneously hypertensive rats it has been shown that blood pressure might not be the sole factor responsible for cardiac enlargement, but that hypertrophy can be the result of genetic cardiovascular abnormality (19, 66). (f) A hypothesis relating the extent of energy utilization to the nuclear activity via NAD+ metabolism has been proposed, which allows for experimental verification (43).
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Zak R,Rabinowitz Mdoi
10.1146/annurev.ph.41.030179.002543subject
Has Abstractpub_date
1979-01-01 00:00:00pages
539-52eissn
0066-4278issn
1545-1585journal_volume
41pub_type
杂志文章,评审abstract::A characteristic feature of the human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell surface projections containing axonemes composed of microtubules and dynein arms, which provide ATP-driven motility. In the airways, cilia function in concert with airway mucus to mediate th...
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更新日期:1991-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:1998-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:1993-01-01 00:00:00
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更新日期:1986-01-01 00:00:00
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更新日期:1983-01-01 00:00:00
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更新日期:1995-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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