Abstract:
:Low oxygen (O2) levels are a naturally occurring feature of embryonic development, adult physiology, and diseases such as those of the cardiovascular system. Although many responses to O2 deprivation are mediated by hypoxia-inducible factors (HIFs), researchers are finding a growing number of HIF-independent pathways that promote O2 conformance and hypoxia tolerance. Here, we describe HIF-independent responses and how they impact cardiovascular tissue homeostasis.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Simon MC,Liu L,Barnhart BC,Young RMdoi
10.1146/annurev.physiol.70.113006.100526subject
Has Abstractpub_date
2008-01-01 00:00:00pages
51-71eissn
0066-4278issn
1545-1585journal_volume
70pub_type
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