Abstract:
:The mammalian kidney is a highly complex organ that requires the precise structural arrangement of multiple cell types for effective function. The need to filter large volumes of plasma at the glomerulus followed by active reabsorption of nearly 99% of that filtrate by the tubules creates vulnerability in both compartments for cell injury. Thus maintenance of cell viability and replacement of those cells that are lost are essential for functional stability of the kidney. This review addresses our current understanding of how cells from the glomerular, tubular, and interstitial compartments arise during development and the manner in which they may be regenerated in the adult organ. In addition, we discuss the data regarding the role of organ-specific and bone marrow-derived stem and progenitor cells in the replacement/repair process, as well as the potential for ex vivo programming of stem cells toward a renal lineage.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Guo JK,Cantley LGdoi
10.1146/annurev.physiol.010908.163245subject
Has Abstractpub_date
2010-01-01 00:00:00pages
357-76eissn
0066-4278issn
1545-1585journal_volume
72pub_type
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