Abstract:
:Multiple organic anion transporters in the proximal tubule of the kidney are involved in the secretion of drugs, toxic compounds, and their metabolites. Many of these compounds are potentially hazardous on accumulation, and it is therefore not surprising that the proximal tubule is also an important target for toxicity. In the past few years, considerable progress has been made in the cloning of these transporters and their functional characterization following heterologous expression. Members of the organic anion transporter (OAT), organic anion transporting polypeptide (OATP), multidrug resistance protein (MRP), sodium-phosphate transporter (NPT), and peptide transporter (PEPT) families have been identified in the kidney. In this review, we summarize our current knowledge on their localization, molecular and functional characteristics, and substrate and inhibitor specificity. A major challenge for the future will be to understand how these transporters work in concert to accomplish the renal secretion of specific anionic substrates.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Russel FG,Masereeuw R,van Aubel RAdoi
10.1146/annurev.physiol.64.081501.155913subject
Has Abstractpub_date
2002-01-01 00:00:00pages
563-94eissn
0066-4278issn
1545-1585pii
64/1/563journal_volume
64pub_type
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