Abstract:
:Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control of BAT thermogenesis. As we enter into a new era of brown fat biology, the next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure. This article reviews the recent major advances in this field and discusses emerging questions.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Kajimura S,Saito Mdoi
10.1146/annurev-physiol-021113-170252subject
Has Abstractpub_date
2014-01-01 00:00:00pages
225-49eissn
0066-4278issn
1545-1585journal_volume
76pub_type
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