Abstract:
:Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently available to prevent it or to promote kidney repair after injury. Animal models demonstrate that the macrophage is a major contributor to the inflammatory response to AKI. Emerging data from human biopsies also corroborate the presence of macrophages in AKI and their persistence in progressive chronic kidney disease. Macrophages are phagocytic innate immune cells that are important mediators of tissue homeostasis and host defense. In response to tissue injury, macrophages become activated based on specific signals from the damaged microenvironment. The activation and functional state of the macrophage depends on the stage of tissue injury and repair, reflecting a dynamic and diverse spectrum of macrophage phenotypes. In this review, we highlight our current understanding of the mechanisms by which macrophages contribute to injury and repair after AKI.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Huen SC,Cantley LGdoi
10.1146/annurev-physiol-022516-034219subject
Has Abstractpub_date
2017-02-10 00:00:00pages
449-469eissn
0066-4278issn
1545-1585journal_volume
79pub_type
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