Abstract:
:During the last five years, cDNAs and genes encoding more than 20 neuroendocrine peptides have been cloned. The information gleaned from these genes has been largely structural to this point, and illustrates the great versatility of neuroendocrine genes in generating diverse sets of bioactive peptides. An ongoing contribution of the application of recombinant DNA techniques to the neuroendocrine system promises to be the identification of novel peptides; it will require a concerted effort to determine their physiological functions. The application of recombinant DNA to the study of expression and regulation of neuroendocrine genes is still in its infancy, but a variety of newly emerging techniques promise to be useful for these approaches. Although we have considered the application of recombinant DNA only to the cloning and analysis of neuroendocrine peptide genes, molecular biology will clearly also have a major future impact in investigating aspects of other molecules involved in neuropeptide action, such as processing enzymes and peptide receptors.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Mayo KE,Evans RM,Rosenfeld GMdoi
10.1146/annurev.ph.48.030186.002243subject
Has Abstractpub_date
1986-01-01 00:00:00pages
431-46eissn
0066-4278issn
1545-1585journal_volume
48pub_type
杂志文章,评审abstract::As stated earlier, the mammalian ovary maintains the continuous development of follicles, but only a few are selected to ovulate and form corpora lutea. These processes are regulated primarily by the gonadotropins and involve specific, sequential changes in the function of theca cells and granulosa cells. Data from re...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.50.030188.002301
更新日期:1988-01-01 00:00:00
abstract::The hedgehog (Hh) signaling pathway plays several diverse regulatory and patterning roles during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In the embryo, fetus, and adult, intestinal Hh signaling is paracrine: Hh ligands are expressed in the endodermally derived epithelium, ...
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更新日期:2011-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:1984-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1985-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.ph.53.030191.001221
更新日期:1991-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev-physiol-021113-170305
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2020-02-10 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2017-02-10 00:00:00
abstract::Hypoxia elicits an array of compensatory responses in animals ranging from protozoa to mammals. Central among these responses is anapyrexia, the regulated decrease of body temperature. The importance of anapyrexia lies in the fact that it reduces oxygen consumption, increases the affinity of hemoglobin for oxygen, and...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
doi:10.1146/annurev.physiol.64.081501.155856
更新日期:2002-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1988-01-01 00:00:00
abstract::The question of respiratory factors limiting exercise has been examined in terms of possible limitations arising from the function of gas exchange, the respiratory mechanics, the energetics of the respiratory muscles, or the development of respiratory muscle fatigue. Exercise capacity is curtailed in the presence of m...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1983-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:2016-01-01 00:00:00
abstract::Calcium and sodium absorption by the kidney normally proceed in parallel. However, a number of physiological, pharmacological, pathological, and genetic conditions dissociate this relation. In each instance, the dissociation can be traced to the distal convoluted tubule, where calcium and sodium transport are inversel...
journal_title:Annual review of physiology
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:2017-02-10 00:00:00
abstract::The phosphoinositides PtdIns(4,5)P2 and PtdIns(3,4,5)P3 are concentrated in plasma membranes of eukaryotic cells, and excluded from endosomes, whereas PtdIns(3)P is formed in these latter intracellular membranes and is apparently excluded from the plasma membrane. The logic of this asymmetric disposition is now reveal...
journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of physiology
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更新日期:2010-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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更新日期:1996-01-01 00:00:00
abstract::Dendritic spines are the postsynaptic components of most excitatory synapses in the mammalian brain. Spines accumulate rapidly during early postnatal development and undergo a substantial loss as animals mature into adulthood. In past decades, studies have revealed that the number and size of dendritic spines are regu...
journal_title:Annual review of physiology
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更新日期:2009-01-01 00:00:00
abstract::A vast number of proteins are involved in synaptic function. Many have been cloned and their functional role defined with varying degrees of success, but their number and complexity currently defy any molecular understanding of the physiology of synapses. A beacon of success in this medieval era of synaptic biology is...
journal_title:Annual review of physiology
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更新日期:2004-01-01 00:00:00
abstract::Practical limitations of the patch-clamp technique when recording mechanogated membrane ion channels are considered. Mechanical overstimulation of the patch or the cell from excessive suction/pressure protocols induces morphological and functional changes. In particular, the plasma membrane becomes decoupled from the ...
journal_title:Annual review of physiology
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更新日期:1997-01-01 00:00:00