Cardiac hypertrophy: the good, the bad, and the ugly.

Abstract:

:Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic stimuli that impose increased biomechanical stress. While hypertrophy can eventually normalize wall tension, it is associated with an unfavorable outcome and threatens affected patients with sudden death or progression to overt heart failure. Accumulating evidence from studies in human patients and animal models suggests that in most instances hypertrophy is not a compensatory response to the change in mechanical load, but rather is a maladaptive process. Accordingly, modulation of myocardial growth without adversely affecting contractile function is increasingly recognized as a potentially auspicious approach in the prevention and treatment of heart failure. In this review, we summarize recent insights into hypertrophic signaling and consider several novel antihypertrophic strategies.

journal_name

Annu Rev Physiol

authors

Frey N,Olson EN

doi

10.1146/annurev.physiol.65.092101.142243

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

45-79

eissn

0066-4278

issn

1545-1585

pii

092101.142243

journal_volume

65

pub_type

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