Abstract:
:A characteristic feature of the human airway epithelium is the presence of ciliated cells bearing motile cilia, specialized cell surface projections containing axonemes composed of microtubules and dynein arms, which provide ATP-driven motility. In the airways, cilia function in concert with airway mucus to mediate the critical function of mucociliary clearance, cleansing the airways of inhaled particles and pathogens. The prototypical disorder of respiratory cilia is primary ciliary dyskinesia, an inherited disorder that leads to impaired mucociliary clearance, to repeated chest infections, and to the progressive destruction of lung architecture. Numerous acquired lung diseases are also marked by abnormalities in both cilia structure and function. In this review we summarize current knowledge regarding airway ciliated cells and cilia, how they function to maintain a healthy epithelium, and how disorders of cilia structure and function contribute to inherited and acquired lung disease.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Tilley AE,Walters MS,Shaykhiev R,Crystal RGdoi
10.1146/annurev-physiol-021014-071931subject
Has Abstractpub_date
2015-01-01 00:00:00pages
379-406eissn
0066-4278issn
1545-1585journal_volume
77pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,评审
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