Abstract:
:Reabsorption of amino acids, similar to that of glucose, is a major task of the proximal kidney tubule. Various amino acids are actively transported across the luminal brush border membrane into proximal tubule epithelial cells, most of which by cotransport. An important player is the newly identified cotransporter (symporter) B0AT1 (SLC6A19), which imports a broad range of neutral amino acids together with Na+ across the luminal membrane and which is defective in Hartnup disorder. In contrast, cationic amino acids and cystine are taken up in exchange for recycled neutral amino acids by the heterodimeric cystinuria transporter. The basolateral release of some neutral amino acids into the extracellular space is mediated by unidirectional efflux transporters, analogous to GLUT2, that have not yet been definitively identified. Additionally, cationic amino acids and some other neutral amino acids leave the cell basolaterally via heterodimeric obligatory exchangers.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Verrey F,Ristic Z,Romeo E,Ramadan T,Makrides V,Dave MH,Wagner CA,Camargo SMdoi
10.1146/annurev.physiol.67.031103.153949subject
Has Abstractpub_date
2005-01-01 00:00:00pages
557-72eissn
0066-4278issn
1545-1585journal_volume
67pub_type
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