Abstract:
:One of the central questions in neurobiology is how experience modifies neural function, and how changes in the nervous system permit an animal to adapt its behavior to a changing environment. Learning and adaptation to a host of different environmental stimuli exemplify processes we know must alter the nervous system because the behavioral output changes after experience. Alterations in behavior after exposure to addictive drugs are a striking example of chemical alterations of nervous system function producing long-lasting changes in behavior. The alterations produced in the central nervous system (CNS) by addictive drugs are of interest because of their relationship to human substance abuse but also because these CNS alterations produce dramatic, easily observed alterations in behavior in response to discrete stimuli. Considerable study has been given to behavioral and biochemical correlates of addiction over the past 50 or more years; however, our understanding of the cellular physiological responses of affected CNS neurons is in its infancy. This review focuses on alterations in cellular and synaptic physiology in the ventral tegmental area (VTA) in response to addictive drugs.
journal_name
Annu Rev Physioljournal_title
Annual review of physiologyauthors
Kauer JAdoi
10.1146/annurev.physiol.66.032102.112534subject
Has Abstractpub_date
2004-01-01 00:00:00pages
447-75eissn
0066-4278issn
1545-1585journal_volume
66pub_type
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journal_title:Annual review of physiology
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pub_type: 杂志文章,评审
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journal_title:Annual review of physiology
pub_type: 杂志文章
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journal_title:Annual review of physiology
pub_type: 传,历史文章,杂志文章
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journal_title:Annual review of physiology
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pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Annual review of physiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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abstract::The serum/glucocorticoid-induced kinase Sgk1 plays an important role in the regulation of epithelial ion transport. This kinase is very rapidly regulated at the transcriptional level as well as via posttranslational modifications involving phosphorylation by the MAP or PI-3 kinase pathways and/or ubiquitylation. Altho...
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journal_title:Annual review of physiology
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更新日期:1998-01-01 00:00:00
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