Fluence Rate Determines PDT Efficiency in Breast Cancer Cells Displaying Different GSH Levels.

abstract：:Phage T7 can be used as a biological UV dosimeter. Its reading is proportional to the inactivation rate expressed in HT7 units. To understand the influence of phage proteins on the formation of DNA UV photoproducts, cyclobutane pyrimidine dimers (CPD) and (6-4)photoproducts ((6-4)PD) were determined in T7 DNA exposed ...

journal_title：Photochemistry and photobiology

authors： Fekete A,Vink AA,Gaspar S,Modos K,Berces A,Ronto G,Roza L

更新日期：1999-05-01 00:00:00

abstract：:Patients infected with human immunodeficiency virus (HIV) have a high prevalence of UV radiation-responsive skin diseases including psoriasis, pruritus, eosinophilic folliculitis and eczemas. On the other hand, UV has been shown to suppress T cell-mediated immune responses and to induce activation and replication of H...

journal_title：Photochemistry and photobiology

authors： Adams ML,Houpt KR,Cruz PD Jr

更新日期：1996-08-01 00:00:00

abstract：:Two-photon laser scanning microscopy (TPLSM) of endogenous reduced nicotinamide adenine dinucleotide (NAD(P)H) provides important information regarding the cellular metabolic state. When imaging the punctate mitochondrial fluorescence originating from NAD(P)H in a rat basophilic leukemia (RBL) cell at low laser powers...

journal_title：Photochemistry and photobiology

authors： Nichols MG,Barth EE,Nichols JA

更新日期：2005-03-01 00:00:00

abstract：:New thio- and seleno-analogs of psoralen were synthesized and analyzed for their photoreactivity toward DNA. Using oligonucleotides of defined sequence, we first showed that these derivatives predominantly generated interstrand crosslinks at 5'-TpA sites. We also observed a surprisingly high reactivity of 7H-thiopyran...

journal_title：Photochemistry and photobiology

authors： Collet M,Sage E,Piette J

更新日期：1997-08-01 00:00:00

abstract：:Herein, we present a study of the pharmacokinetics and biodistribution of a butadiyne-linked conjugated porphyrin dimer (Oxdime) designed to have high near-infrared (NIR) 2-photon absorption cross-section for photodynamic therapy (PDT). Changes in biodistribution over time were monitored in mice carrying B16-F10 melan...

journal_title：Photochemistry and photobiology

authors： Khurana M,Ulrich S,Kim A,Moriyama Y,Netchev G,Akens MK,Anderson HL,Wilson BC

更新日期：2012-11-01 00:00:00

abstract：:Central venous catheters (CVC) are widely used in the United States and are associated with 250,000 to 500,000 CVC-related infections in hospitals annually. We used a catheter made from ultraviolet-C (UVC) transmissive material to test whether delivery of UVC from the lumen would allow inactivation of microorganisms o...

journal_title：Photochemistry and photobiology

authors： Dai T,Tegos GP,St Denis TG,Anderson D,Sinofsky E,Hamblin MR

更新日期：2011-01-01 00:00:00

abstract：:Fabrea salina is a marine ciliate that shows photomotile responses such as positive phototaxis and a step-down photophobic reaction. We found that preilluminated F. salina cells show a phototactic response significantly greater than that of dark-adapted cells when exposed to the same phototactic light stimulus. In par...

journal_title：Photochemistry and photobiology

authors： Marangoni R,Colombetti G

更新日期：2003-02-01 00:00:00

abstract：:The photophysical properties of two energy-transfer dyads that are potential candidates for near-infrared (NIR) imaging probes are investigated as a function of solvent polarity. The dyads (FbC-FbB and ZnC-FbB) contain either a free base (Fb) or zinc (Zn) chlorin (C) as the energy donor and a free base bacteriochlorin...

journal_title：Photochemistry and photobiology

authors： Kee HL,Diers JR,Ptaszek M,Muthiah C,Fan D,Lindsey JS,Bocian DF,Holten D

更新日期：2009-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) with photosensitizer verteporfin is a clinically approved vascular disrupting modality that is currently in clinical trial for cancer treatment. In this study, we evaluated PDT in combination with either mTORC1 inhibitor rapamycin or mTORC1/C2 dual inhibitor AZD2014 for therapeutic enhanceme...

journal_title：Photochemistry and photobiology

authors： Kraus D,Palasuberniam P,Chen B

更新日期：2020-03-01 00:00:00

abstract：:The UVA and UVB components of sunlight can produce three classes of bipyrimidine DNA photolesions [cyclobutane pyrimidine dimers (CPDs), pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) and related Dewar valence isomers (DewarPPs)]. The UVA/UVB ratio of sunlight is high in winter and low in summer in the Northern He...

journal_title：Photochemistry and photobiology

authors： Nishimura K,Ikehata H,Douki T,Cadet J,Sugiura S,Mori T

更新日期：2020-12-03 00:00:00

abstract：:A concept has been presented whereby X-ray irradiation can be used to induce visible luminescence of chromophores such as porphyrins. The essential aspects of the idea have been demonstrated in a supramolecular assembly consisting of a water-dispersed polystyrene latex with an embedded scintillating compound, 2,5-diph...

journal_title：Photochemistry and photobiology

authors： Kokotov S,Lewis A,Neumann R,Amrusi S

更新日期：1994-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) using the second-generation photosensitizer phthalocyanine (Pc) 4 causes mitochondrial damage and induces apoptosis through the release of cytochrome c to the cytosol. Another protein of the mitochondrial intermembrane space, Smac/DIABLO (second mitochondria-derived activator of caspase/dire...

journal_title：Photochemistry and photobiology

authors： Usuda J,Chiu SM,Azizuddin K,Xue LY,Lam M,Nieminen AL,Oleinick NL

更新日期：2002-08-01 00:00:00

abstract：:The proteins induced by heat and other stressors, called heat shock proteins (HSP) or stress proteins, are considered to play a general role in protection from cellular injury. Exposure to UVA (320-400 nm) following application of 8-methoxypsoralen (8-MOP), termed PUVA is commonly used in the field of dermatology. In ...

journal_title：Photochemistry and photobiology

authors： Muramatsu T,Yamashina Y,Tada H,Kobayashi N,Yamaji M,Ohno H,Shirai T,Takahashi A,Ohnishi T

更新日期：1993-12-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 inhibitors are known to be used as chemopreventative agents against certain malignancies. Thus far, there has been very limited information on whether COX-2 inhibitors protect against chronic narrow-band UVB (NB-UVB)-induced immunosuppression. The present study investigated the effect of nonsele...

journal_title：Photochemistry and photobiology

authors： Wu Y,Tai CL,Wei H,He F,Wang Y,Zhao Y,Chen HD

更新日期：2008-03-01 00:00:00

abstract：:We have been able to identify a blue fluorophore from the low-molecular weight soluble fraction of human adult nondiabetic brunescent cataract lenses as xanthurenic acid 8-O-beta-D-glucoside (XA8OG) (excitation = 338 nm and emission = 440 nm). To determine the role of this fluorophore in the lens, we have examined its...

journal_title：Photochemistry and photobiology

authors： Thiagarajan G,Shirao E,Ando K,Inoue A,Balasubramanian D

更新日期：2002-09-01 00:00:00

abstract：:Among beetle luciferases, the pH-sensitive firefly luciferases have been studied extensively. Much less is known about pH-insensitive luciferases, which include click beetle and railroad worm luciferases. Previously, we found that the residues R215 and T226 (N230) are important for green light emission. Here we show t...

journal_title：Photochemistry and photobiology

authors： Viviani VR,Uchida A,Viviani W,Ohmiya Y

更新日期：2002-11-01 00:00:00

abstract：:UVR8 is the only known plant photoreceptor that mediates light responses to UV-B (280-315 nm) of the solar spectrum. UVR8 perceives a UV-B signal via light-induced dimer dissociation, which triggers a wide range of cellular responses involved in photomorphogenesis and photoprotection. Two recent crystal structures of ...

journal_title：Photochemistry and photobiology

authors： Yang X,Montano S,Ren Z

更新日期：2015-09-01 00:00:00

abstract：:Flash-induced absorbance spectroscopy was used to analyze the proton uptake and electron transfer properties of photosynthetic reaction centers (RC) of Rhodobacter capsulatus that have been genetically modified near the primary quinone electron acceptor (Q(A)). M246Ala and M247Ala, which are symmetry-related to the po...

journal_title：Photochemistry and photobiology

authors： Tandori J,Miksovska J,Valerio-Lepiniec M,Schiffer M,Maróti P,Hanson DK,Sebban P

更新日期：2002-02-01 00:00:00

abstract：:The mutant T203V of the light driven chloride pump halorhodopsin from Halobacterium salinarum was crystallized and the X-ray structure was solved at 1.6 angstroms resolution. The T203V structure turned out to be nearly identical to the wild type protein with a root mean square deviation of 0.43 angstroms for the carbo...

journal_title：Photochemistry and photobiology

authors： Gmelin W,Zeth K,Efremov R,Heberle J,Tittor J,Oesterhelt D

更新日期：2007-03-01 00:00:00

abstract：:Topical photodynamic therapy is used for a variety of malignant and pre-malignant skin disorders, including Bowen's Disease and Superficial Basal Cell Carcinoma. A haem precursor, typically 5-aminolevulinic acid (ALA), acting as a prodrug, is absorbed and converted by the haem biosynthetic pathway to photoactive proto...

journal_title：Photochemistry and photobiology

authors： Donnelly RF,McCarron PA,Woolfson AD

更新日期：2005-07-01 00:00:00

abstract：:The seminal discovery by James Cleaver of defective DNA repair in xeroderma pigmentosum (XP) opened up an ever-expanding field of DNA repair-related disorders. In addition, it put XP on the map and has led to improved diagnosis, care and management of affected patients. In the United Kingdom, we recently established a...

journal_title：Photochemistry and photobiology

authors： Lehmann AR

更新日期：2015-03-01 00:00:00

abstract：:Vibrio fischeri strain Y1 emits yellow light in vivo due to the participation of a yellow fluorescent protein (YFP) in the luciferase reaction. In this study it was found that the organism also produces a protein (referred to as Y1-BFP) emitting strong blue fluorescence. Its molecular weight, about 25 kDa, is the same...

journal_title：Photochemistry and photobiology

authors： Karatani H,Wilson T,Hastings JW

更新日期：1992-02-01 00:00:00

abstract：:Assignment of the fluorescence spectrum of firefly luciferin in aqueous solutions was achieved by utilizing not only emission energies but also theoretical absorption spectra and relative concentrations as estimated by pKa values. Calculated Gibbs free energies were utilized to estimate pKa values. These pKa values we...

journal_title：Photochemistry and photobiology

authors： Hiyama M,Akiyama H,Yamada K,Koga N

更新日期：2014-01-01 00:00:00

abstract：:A model of UV-induced DNA damage in oceanic bacterioplankton was developed and tested against previously published and novel measurements of cyclobutane pyrimidine dimers (CPD) in surface layers of the ocean. The model describes the effects of solar irradiance, wind-forced mixing of bacterioplankton and optical proper...

journal_title：Photochemistry and photobiology

authors： Huot Y,Jeffrey WH,Davis RF,Cullen JJ

更新日期：2000-07-01 00:00:00

abstract：:There are controversial reports in the literature concerning the reactivity of singlet oxygen ((1)O(2)) with the redox probe 2',7'-dichlorodihydrofluorescein (DCFH). By carefully preparing solutions in which (1)O(2) is quantitatively generated in the presence of DCFH, we were able to show that the formation rate of th...

journal_title：Photochemistry and photobiology

authors： Daghastanli NA,Itri R,Baptista MS

更新日期：2008-09-01 00:00:00

abstract：:Many viral infections reach clinical significance in winter, when it is cold, relative humidity is lowest and vitamin D production from solar ultraviolet-B irradiation is at its nadir. Several autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus and asthma, are linked to viral infections. Vitamin ...

journal_title：Photochemistry and photobiology

authors： Grant WB

更新日期：2008-03-01 00:00:00

abstract：:Fibrous proteins discolor on exposure to the UV component of sunlight. This effect is exacerbated in the presence of fluorescent whitening agents (FWAs), which are often applied to textiles to improve product brightness. Tryptophan photoproducts have been identified as significant contributors to protein photoyellowin...

journal_title：Photochemistry and photobiology

authors： Dyer JM,Clerens S,Cornellison CD,Murphy CJ,Maurdev G,Millington KR

更新日期：2009-11-01 00:00:00

abstract：:The modifications induced by reactive oxygen species (ROS) on fluorescent proteins (FPs) may have important implications for live cell fluorescence imaging. Using quantitative gamma-radiolysis, we have studied the ROS-induced biochemical and photophysical perturbations on recombinant cyan fluorescent protein (CFP). Af...

journal_title：Photochemistry and photobiology

authors： Alvarez L,Levin CH,Merola F,Bizouarn T,Pasquier H,Baciou L,Rusconi F,Erard M

更新日期：2010-01-01 00:00:00

abstract：:The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly suggest that nuclear DNA ...

journal_title：Photochemistry and photobiology

authors： Horio T,Miyauchi-Hashimoto H,Kuwamoto K,Yamazaki F,Okamoto H

更新日期：2007-01-01 00:00:00

abstract：:We have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (Fisher rat thyroid cells, FRTL-5) and to two neoplastic cell lines, a thyroid carcinoma (TK-6) and its lung metastasis (MPTK-6). Whereas the cell lines are equally sensitive to the drug in the dark, if irradiated...

journal_title：Photochemistry and photobiology

authors： Andreoni A,Colasanti A,Kisslinger A,Mastrocinque M,Portella G,Riccio P,Roberti G

更新日期：1993-05-01 00:00:00