Photoproducts formed in the photoyellowing of collagen in the presence of a fluorescent whitening agent.

Abstract:

:Fibrous proteins discolor on exposure to the UV component of sunlight. This effect is exacerbated in the presence of fluorescent whitening agents (FWAs), which are often applied to textiles to improve product brightness. Tryptophan photoproducts have been identified as significant contributors to protein photoyellowing; however, the role of non-tryptophan-derived chromophores is less clear. In this study bovine collagen, containing no tryptophan residues, was irradiated in the presence and absence of the stilbene-derived FWA, 4,4'-bis(2-sulfostyryl)biphenyl (DSBP) and photoproducts were identified using mass spectrometry. Photoyellowing was found to be dependent on the presence of the FWA, attributed to amplified generation of reactive oxygen species (ROS), particularly hydroxyl radicals and peroxynitrite. Four key proteinaceous photomodifications contributing directly to photoyellowing were located in irradiated collagen pretreated with DSBP, namely dopa, nitrophenylalanine, nitrotyrosine and nitrohistidine. This represents the first direct characterization of the three nitrated residues in the photoyellowing of an isolated fibrous protein, and implicates the ROS, peroxynitrite, as a key contributor to protein photoyellowing. Direct oxidative modification of the FWA itself was also observed. This study demonstrates that, even in the absence of tryptophan residues, significant photomodification of protein residues leading to chromophore formation occurs in the presence of an FWA.

journal_name

Photochem Photobiol

authors

Dyer JM,Clerens S,Cornellison CD,Murphy CJ,Maurdev G,Millington KR

doi

10.1111/j.1751-1097.2009.00614.x

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

1314-21

issue

6

eissn

0031-8655

issn

1751-1097

pii

PHP614

journal_volume

85

pub_type

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