Enhanced response to daunomycin of normal, tumor and metastatic cell lines via drug photoactivation.

Abstract:

:We have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (Fisher rat thyroid cells, FRTL-5) and to two neoplastic cell lines, a thyroid carcinoma (TK-6) and its lung metastasis (MPTK-6). Whereas the cell lines are equally sensitive to the drug in the dark, if irradiated during incubation with daunomycin (86 J/cm2 at 488 nm), they become more and differently sensitive. Namely, the drug doses producing 50% mortality decrease by factors of about 22, 28 and 16 for FRTL-5, TK-6 and MPTK-6 cell lines, respectively. This result correlates with differences in drug uptake and resistance observed in the normal and neoplastic cell lines.

journal_name

Photochem Photobiol

authors

Andreoni A,Colasanti A,Kisslinger A,Mastrocinque M,Portella G,Riccio P,Roberti G

doi

10.1111/j.1751-1097.1993.tb09223.x

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

851-5

issue

5

eissn

0031-8655

issn

1751-1097

journal_volume

57

pub_type

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