Abstract:
:Restenosis results from intimal hyperplasia and constrictive remodeling following cardiovascular interventions. Photodynamic therapy (PDT) has been shown to inhibit intimal hyperplasia in vivo by preventing neointimal repopulation of the treated vessel. This study was undertaken in an attempt to further dissect the mechanisms by which PDT acts on secreted and extracellular matrix proteins to inhibit migration of cultured human vascular cells. PDT of three-dimensional collagen gels inhibited invasive human smooth muscle cell (SMC) migration, whereas cell-derived matrix metalloproteinase production remained unaltered. Additionally, PDT generated cross-links in the collagen gels, a result substantiated in an ex vivo model whereby PDT rendered the treated vessels resistant to pepsin digestion and inhibited invasive migration of SMC and fibroblasts. These data support the premise that by inducing matrix protein cross-links, rendering the vessel resistant to degradation, in vivo PDT inhibits repopulation of the vessel and therefore intimal hyperplasia.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Waterman PR,Overhaus M,Heckenkamp J,Nigri GR,Fungaloi PF,Landis ME,Kossodo SC,LaMuraglia GMdoi
10.1562/0031-8655(2002)075<0046:morhvc>2.0.co;2subject
Has Abstractpub_date
2002-01-01 00:00:00pages
46-50issue
1eissn
0031-8655issn
1751-1097journal_volume
75pub_type
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