New triruthenium clusters as photoinduced DNA-binding and cleaving agents.

Abstract:

:1-Hydroxybenzotriazole and 1-hydroxypyridine-2-thione were incorporated as ligands with the cluster Ru3(CO)10 (NCMe)2 to give [(mu-H)Ru3(CO)10(mu2-2,3-eta2-NNN(O)C6 H4)] and [(mu-H)Ru3(CO)9(mu2-eta1 : eta2-C5H4N(O)S)], respectively. Irradiation of these two new triruthenium metal clusters individually with 350 nm UV light in a phosphate buffer (pH 6.0) containing form I DNA resulted in single-strand cleavage. Cluster [(mu-H)Ru3(CO)10(mu2-2,3--eta2-NNN (O)C6H4)] was also found to bind to calf thymus DNA upon UV irradiation.

journal_name

Photochem Photobiol

authors

Hwu JR,Kuang-Lieh L,Yu SF,Yu LJ,Kumaresan S,Lin KJ,Tsay SC

doi

10.1562/0031-8655(2002)075<0457:ntcapd>2.0.co;2

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

457-61

issue

5

eissn

0031-8655

issn

1751-1097

journal_volume

75

pub_type

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