Photobleaching of reduced nicotinamide adenine dinucleotide and the development of highly fluorescent lesions in rat basophilic leukemia cells during multiphoton microscopy.

abstract：:Fibrous proteins discolor on exposure to the UV component of sunlight. This effect is exacerbated in the presence of fluorescent whitening agents (FWAs), which are often applied to textiles to improve product brightness. Tryptophan photoproducts have been identified as significant contributors to protein photoyellowin...

journal_title：Photochemistry and photobiology

authors： Dyer JM,Clerens S,Cornellison CD,Murphy CJ,Maurdev G,Millington KR

更新日期：2009-11-01 00:00:00

abstract：:Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturat...

journal_title：Photochemistry and photobiology

authors： Alegría AE,Zayas L,Guevara N

更新日期：1995-09-01 00:00:00

abstract：:Confocal laser microspectrofluorometric measurements on human T47D mammary tumor cells have been performed to assess the intracellular distribution of hypericin within the various cell compartments: cytoplasmic membrane, cytoplasm and nucleus. Confocal fluorescence measurements obtained from microvolumes (approximatel...

journal_title：Photochemistry and photobiology

authors： Miskovsky P,Sureau F,Chinsky L,Turpin PY

更新日期：1995-09-01 00:00:00

abstract：:Positively charged zinc containing or metal free phthalocyanines 6a-c and 7a-c were prepared via a three step procedure starting from 4-nitrophthalonitrile. The phthalocyanines contain alkyl chains of different length in order to influence the hydrophilic vs lipophilic character of the compounds. The partition between...

journal_title：Photochemistry and photobiology

authors： Wöhrle D,Iskander N,Graschew G,Sinn H,Friedrich EA,Maier-Borst W,Stern J,Schlag P

更新日期：1990-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is frequently accompanied by induction of systemic immunosuppression. Photochemical mechanisms underlying this effect are not completely understood. Here, we demonstrate the immunosuppressive activity of photooxidation products of protoporphyrin IX dimethyl ester (PPIX) in a murine model of ...

journal_title：Photochemistry and photobiology

authors： Kyagova AA,Mansurova GV,Kozir LA,Ponomarev GV,Pavlov VY,Konstantinov IO,Potapenko AY

更新日期：2005-11-01 00:00:00

abstract：:Several studies in the literature indicate that histones (lysine rich proteins found associated with DNA in eukaryotic chromatin), as well as poly-L-lysine, can be photocross-linked by ultraviolet (UV) light to DNA in which 5-bromo-2'-deoxyuridine has been substituted for thymidine. To gain some insight into the possi...

journal_title：Photochemistry and photobiology

authors： Shetlar MD,Rose RB,Hom K,Shaw AA

更新日期：1991-05-01 00:00:00

abstract：:The photocycle in photoactive yellow protein (PYP) crystals was studied by single-crystal absorption spectroscopy with experimental setups for low-temperature and time-resolved measurements. Thin and flat PYP crystals, suitable for light absorption studies, were obtained using special crystallization conditions. Illum...

journal_title：Photochemistry and photobiology

authors： Kort R,Ravelli RB,Schotte F,Bourgeois D,Crielaard W,Hellingwerf KJ,Wulff M

更新日期：2003-08-01 00:00:00

abstract：:The tetraruthenated porphyrin, mu-[meso-5,10,15,20-tetra(pyridyl)porphyrin]tetrakis[bis-(bipyridine) chloride ruthenium(II)] (TRP) is a supramolecular cationic species. The aim of the present investigation was to evaluate the photodynamic properties of TRP and Zn-TRP to damage DNA with emphasis on the mechanistic aspe...

journal_title：Photochemistry and photobiology

authors： Ravanat JL,Cadet J,Araki K,Toma HE,Medeiros MH,Mascio PD

更新日期：1998-11-01 00:00:00

abstract：:A careful study of the linoleic acid hydroperoxide (LOOH) profile obtained upon peroxidation of linoleic acid (LA) photosensitized by tiaprofenic acid (TPA) and analogous ketones has been undertaken to distinguish between type-I and type-II photoperoxidation mechanisms. 1,4-Cyclohexadiene and 1,2-dimethylcyclohexa-2,5...

journal_title：Photochemistry and photobiology

authors： Samadi A,Martínez LA,Miranda MA,Morera IM

更新日期：2001-04-01 00:00:00

abstract：:Ultraviolet radiation can inhibit immune responses locally as well as systemically. Such effects have been measured in animals and humans exposed to ultraviolet B (wavelength 280-315 nm) (UVB) and ultraviolet A (315-400 nm) (UVA). The precise wavelength dependence is important for the identification of possible molecu...

journal_title：Photochemistry and photobiology

authors： Garssen J,de Gruijl F,Mol D,de Klerk A,Roholl P,Van Loveren H

更新日期：2001-04-01 00:00:00

abstract：:δ-Aminolevulinic acid (ALA)-induced porphyrin accumulation is widely used in the treatment of cancer, as photodynamic therapy. To clarify the mechanisms of the tumor-preferential accumulation of protoporphyrin, we examined the effect of the expression of heme-biosynthetic and -degradative enzymes on the ALA-induced ac...

journal_title：Photochemistry and photobiology

authors： Ohgari Y,Miyata Y,Miyagi T,Gotoh S,Ohta T,Kataoka T,Furuyama K,Taketani S

更新日期：2011-09-01 00:00:00

abstract：:Chronic exposure of the gray, short-tailed oppossum, Monodelphis domestica to ultraviolet radiation (UVR) induces mesenchymal tumors of the cornea. High molecular weight DNA samples from 6 UVR-induced corneal tumors were assayed for their ability to transform NIH 3T3 cells to tumorigenicity. NIH 3T3 cells transfected ...

journal_title：Photochemistry and photobiology

authors： Sabourin CL,Freeman AG,Kusewitt DF,Ley RD

更新日期：1992-03-01 00:00:00

abstract：:The temperature dependence of the uptake phase of 5-aminolevulinic acid (ALA) and the following production phase of protoporphyrin IX (PpIX) in normal mouse skin was investigated. A cream containing 20% ALA was topically applied on the skin for 10 min. The amount of ALA-induced PpIX was evaluated by measuring the fluo...

journal_title：Photochemistry and photobiology

authors： Juzenas P,Sørensen R,Iani V,Moan J

更新日期：1999-04-01 00:00:00

abstract：:Proteases like urokinase-type plasminogen activator (uPA) play an important role in tumor invasion. Cells derived from ultraviolet radiation (UVR)-induced corneal sarcomas of Monodelphis domestica produce relatively high levels of uPA compared to the untransformed keratocytes suggesting a mechanism for their invasiven...

journal_title：Photochemistry and photobiology

authors： Green WB,McGuire PG,Miska KB,Kusewitt DF

更新日期：2001-03-01 00:00:00

abstract：:Magnetic field effect studies of alkylcobalamin photolysis provide evidence for the formation of a reactive radical pair that is born in the singlet spin state. The radical pair recombination process that is responsible for the magnetic field dependence of the continuous-wave (CW) quantum yield is limited to the diffu...

journal_title：Photochemistry and photobiology

authors： Natarajan E,Grissom CB

更新日期：1996-08-01 00:00:00

abstract：:Many biomolecules contain photoactive reducing agents, such as reduced nicotinamide adenine dinucleotide (NADH) and 6-thioguanine (6-TG) incorporated into DNA through drug metabolism. These reducing agents may produce reactive oxygen species under UVA irradiation or act as electron donors in various media. The interac...

journal_title：Photochemistry and photobiology

authors： Quinones M,Zhang Y,Riascos P,Hwang HM,Aker WG,He X,Gao R

更新日期：2014-03-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are involved in the control of virtually all aspects of our behavior and physiology. Activated receptors catalyze nucleotide exchange in heterotrimeric G proteins (composed of alpha.GDP, beta and gamma subunits) on the inner surface of the cell membrane. The GPCR rhodopsin and the G...

journal_title：Photochemistry and photobiology

authors： Chen Y,Herrmann R,Fishkin N,Henklein P,Nakanishi K,Ernst OP

更新日期：2008-07-01 00:00:00

abstract：:A targeting strategy based on the selective enzyme-mediated activation of polymeric photosensitizer prodrugs (PPP) within pathological tissue has led to the development of agents with the dual ability to detect and treat cancer. Herein, a detailed study of a simple model system for these prodrugs is described. We prep...

journal_title：Photochemistry and photobiology

authors： Campo MA,Gabriel D,Kucera P,Gurny R,Lange N

更新日期：2007-07-01 00:00:00

abstract：:UVR8 is the only known plant photoreceptor that mediates light responses to UV-B (280-315 nm) of the solar spectrum. UVR8 perceives a UV-B signal via light-induced dimer dissociation, which triggers a wide range of cellular responses involved in photomorphogenesis and photoprotection. Two recent crystal structures of ...

journal_title：Photochemistry and photobiology

authors： Yang X,Montano S,Ren Z

更新日期：2015-09-01 00:00:00

abstract：:The contribution of DNA strand breaks accumulating in the course of nucleotide excision repair to upregulation of the p53 tumor suppressor protein was investigated in human dermal fibroblast strains after treatment with 254 nm ultraviolet (UV) light. For this purpose, fibroblast cultures were exposed to UV and incubat...

journal_title：Photochemistry and photobiology

authors： Enns L,Murray D,Mirzayans R

更新日期：2000-10-01 00:00:00

abstract：:Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known that this property contributes to psoralen's clinical efficacy in several disease contexts, which include vitiligo, psoriasis, graft-versus-host disease and cutan...

journal_title：Photochemistry and photobiology

authors： Buhimschi AD,Gooden DM,Jing H,Fels DR,Hansen KS,Beyer WF Jr,Dewhirst MW,Walder H,Gasparro FP

更新日期：2020-09-01 00:00:00

abstract：:Quantum yields of firefly bioluminescence reactions were determined for beetle luciferases from the three main families of luminous beetles emitting different bioluminescence colors. Quantum yield (QY) was significantly correlated with luminescence spectrum. The green light-emitting luciferase of the Brazilian click b...

journal_title：Photochemistry and photobiology

authors： Niwa K,Ichino Y,Kumata S,Nakajima Y,Hiraishi Y,Kato D,Viviani VR,Ohmiya Y

更新日期：2010-09-01 00:00:00

abstract：:The photodynamic therapy (PDT) activity of the bis(dimethylthexylsiloxy)silicon 2,3-naphthalocyanine (SiNc 8) was evaluated against the EMT-6 tumor implanted intradermally in BALB/c mice. The SiNc 8 was formulated in aqueous emulsions based on Cremophor EL or Solutol HS 15. The formulation was shown to affect plasma c...

journal_title：Photochemistry and photobiology

authors： Brasseur N,Ouellet R,Lewis K,Potter WR,van Lier JE

更新日期：1995-12-01 00:00:00

abstract：:Photobiologic and synthetic versatility of hydrazones has not yet been established with (1)O2 as a route to commonly encountered nitrosamines. Thus, to determine whether the "parent" reaction of formalhydrazone and (1)O2 leads to facile C=N bond cleavage and resulting nitrosamine formation, we have carried out CCSD(T)...

journal_title：Photochemistry and photobiology

authors： Rudshteyn B,Castillo A,Ghogare AA,Liebman JF,Greer A

更新日期：2014-03-01 00:00:00

abstract：:We report that exo- and endogenous guanosine 3',5'-cyclic monophosphate (cGMP) specifically influenced the photophobic response. In behavioral experiments the slowly hydrolyzable and membrane-permeable analogs of cGMP (8-bromo-cGMP [Br-cGMP] and N6,2'-o-dibutyryl-cGMP) dramatically prolonged the time for ciliary stop ...

journal_title：Photochemistry and photobiology

authors： Walerczyk M,Fabczak S

更新日期：2001-12-01 00:00:00

abstract：:Nuclear factor-kappa B (NF-kappaB) plays an important role in UV-induced skin tumorigenesis. Activation of NF-kappaB by UV-irradiation is composed of two phases. The early phase culminates with maximal levels of DNA binding ability at 4 h postirradiation and is dependent on translational inhibition. The late-phase act...

journal_title：Photochemistry and photobiology

authors： László CF,Wu S

更新日期：2008-11-01 00:00:00

abstract：:The significance of human cutaneous pigmentation lies in its protective role against sun-induced DNA damage and photocarcinogenesis. Fair skin and red hair are characterized by a low eumelanin to pheomelanin ratio, and have been associated with increased risk of skin cancer. Cutaneous pigmentation is a complex genetic...

journal_title：Photochemistry and photobiology

authors： Dessinioti C,Antoniou C,Katsambas A,Stratigos AJ

更新日期：2011-09-01 00:00:00

abstract：:We previously reported that the efficacy of photodynamic therapy (PDT) in cell culture was enhanced by ursodeoxycholic acid (UDCA), a nontoxic bile acid. In this study, we examined the ability of UDCA to promote tumor control by PDT in the mouse, using the radiation-induced fibrosarcoma tumor and the photosensitizing ...

journal_title：Photochemistry and photobiology

authors： Garbo GM,Vicente MG,Fingar V,Kessel D

更新日期：2003-10-01 00:00:00

abstract：:The blue light photoreceptor phototropin mediates crucial processes in plants leading to optimization of photosynthesis. Phototropin comprises two flavin mononucleotide-binding LOV (light-, oxygen-, or voltage-sensitive) domains. The LOV domains undergo a photocycle upon illumination, in which two intermediates have b...

journal_title：Photochemistry and photobiology

authors： Bauer C,Rabl CR,Heberle J,Kottke T

更新日期：2011-05-01 00:00:00

abstract：:Latia neritoides is a small limpet-like snail that produces a bright green bioluminescence (BL) via a unique light-emitting system. The process, mechanism, and even light emitter of its light emission remain unknown, although this BL has been known for decades. Unlike the other BL systems, neither the luciferin (Luc) ...

journal_title：Photochemistry and photobiology

authors： Yu M,Ohmiya Y,Naumov P,Liu YJ

更新日期：2018-05-01 00:00:00