A comparative study of the visible light photochemistry of gilvocarcins V and M.

Abstract:

:Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturated dry DMSO was also determined. These values are not different, within experimental error, from those corresponding to gilvocarcin V (GV). Because GV is a strong photocytotoxic agent and GM is not, these results imply that Type I and Type II mechanisms are not important pathways in the cytotoxicity of GV.

journal_name

Photochem Photobiol

authors

Alegría AE,Zayas L,Guevara N

doi

10.1111/j.1751-1097.1995.tb02361.x

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

409-15

issue

3

eissn

0031-8655

issn

1751-1097

journal_volume

62

pub_type

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