Prodromal PD: A new nosological entity.

Abstract:

:Recent years have brought a rapid growth in knowledge of the prodromal phase of Parkinson's disease (PD). It is now clear that the clinical phase of PD is preceded by a phase of progressing neurodegeneration lasting many years. This involves not only central nervous system structures outside the substantia nigra and neurotransmitter systems other than the dopaminergic system, but also the peripheral nervous systems. Different ways of alpha-synuclein spreading are presumed, corresponding to typical prodromal non-motor symptoms like constipation, REM sleep behavior disorder (RBD) and hyposmia. Moreover, many risk and prodromal markers have been identified and combined in the prodromal research criteria, which can be used to calculate an individual's probability of being in the prodromal phase of PD. Apart from specific genetic risk markers, including most importantly GBA- and LRRK2 mutations, RBD is currently the most important prodromal marker, predicting PD with a very high likelihood. This makes individuals with RBD a promising cohort for future clinical trials to detect and treat PD in its prodromal phase. New markers, especially those derived from tissue biopsies, quantitative motor assessment and imaging, appear very promising; these are paving the way for a better understanding of the prodromal phase and its potential clinicopathological subtypes, and a more precise probability calculation.

journal_name

Prog Brain Res

authors

Schaeffer E,Postuma RB,Berg D

doi

10.1016/bs.pbr.2020.01.003

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

331-356

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(20)30003-0

journal_volume

252

pub_type

杂志文章,评审
  • Physiological properties and afferent connections of the locus coeruleus and adjacent tegmental neurons involved in the generation of paradoxical sleep in the cat.

    abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63798-x

    authors: Sakai K

    更新日期:1991-01-01 00:00:00

  • The subiculum: cytoarchitectonically a simple structure, but hodologically complex.

    abstract::The subiculum gives rise to the majority of hippocampal projections to various telencephalic and diencephalic structures. Previously, these projections have been described using anterograde tracing with radioactively labeled amino acids. As part of an ongoing detailed analysis of the connectivity of the hippocampal re...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)61240-6

    authors: Witter MP,Groenewegen HJ

    更新日期:1990-01-01 00:00:00

  • Effects of spinal cord injury on synaptic inputs to sympathetic preganglionic neurons.

    abstract::Spinal cord injuries often lead to disorders in the control of autonomic function, including problems with blood pressure regulation, voiding, defecation and reproduction. The root cause of all these problems is the destruction of brain pathways that control spinal autonomic neurons lying caudal to the lesion. Changes...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)52001-6

    authors: Llewellyn-Smith IJ,Weaver LC,Keast JR

    更新日期:2006-01-01 00:00:00

  • Prostaglandin-induced neuropeptide release from spinal cord.

    abstract::The studies reviewed in this chapter present a convincing argument that prostaglandins have direct actions at the level of the spinal cord to enhance nociception. Furthermore, an increasing body of evidence supports the hypothesis that one important site of action of these eicosanoids is the terminals of sensory neuro...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61801-4

    authors: Vasko MR

    更新日期:1995-01-01 00:00:00

  • Oscillations in the cerebellar cortex: a prediction of their frequency bands.

    abstract::Local recurrent connections endow the cerebellar cortex with an intrinsic dynamics. We performed computer simulations to predict the frequency bands of the oscillations that will most likely emerge. Feedback inhibition from the Golgi to the granule cells induced 10-50 Hz oscillations, the period at resonance being app...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(04)48015-7

    authors: Maex R,De Schutter E

    更新日期:2005-01-01 00:00:00

  • Spontaneous fMRI activity during resting wakefulness and sleep.

    abstract::Functional magnetic resonance imaging (fMRI) studies performed during both waking rest and sleep show that the brain is continually active in distinct patterns that appear to reflect its underlying functional connectivity. In this review, potential sources that contribute to spontaneous fMRI activity will be discussed...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53839-0.00019-3

    authors: Duyn J

    更新日期:2011-01-01 00:00:00

  • Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.

    abstract::The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase th...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)00006-4

    authors: Abel T,Nguyen PV

    更新日期:2008-01-01 00:00:00

  • Heat acclimation: a unique model of physiologically mediated global preconditioning against traumatic brain injury.

    abstract::Sub-lethal exposure to practically any harmful stimulus has been shown to induce consequent protection against more severe stress. This preconditioning (PC) effect may be achieved by exposure to different stressors, indicating that the induction of tolerance involves activation of common protective pathways. Chronic e...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)61025-X

    authors: Shein NA,Horowitz M,Shohami E

    更新日期:2007-01-01 00:00:00

  • Morphogenesis timing of genetically programmed brain malformations in relation to epilepsy.

    abstract::Cerebral malformations are best understood as abnormal tissue morphogenesis in the context of disorders of ontogenesis. In neuroembryology, the timing of onset and duration of abnormal genetic expression and neurodevelopmental processes are primordial and must always be assessed, regardless whether the dysgenesis is p...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-63326-2.00010-7

    authors: Sarnat HB,Flores-Sarnat L

    更新日期:2014-01-01 00:00:00

  • Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse.

    abstract::The serotonin (5-HT) neurotransmitter system provides fundamental modulatory regulation of the limbic-corticostriatal circuitry known to be vital in the development of addiction as well as the aspects of addiction that hinder recovery and contribute to relapse. Thus, components of the 5-HT system may provide novel tar...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)00916-3

    authors: Bubar MJ,Cunningham KA

    更新日期:2008-01-01 00:00:00

  • Consciousness and epilepsy: why are patients with absence seizures absent?

    abstract::Epileptic seizures cause dynamic, reversible changes in brain function and are often associated with loss of consciousness. Of all seizure types, absence seizures lead to the most selective deficits in consciousness, with relatively little motor or other manifestations. Impaired consciousness in absence seizures is no...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)50020-7

    authors: Blumenfeld H

    更新日期:2005-01-01 00:00:00

  • Repair of connections in injured neonatal and embryonic spinal cord in vitro.

    abstract::A remarkable preparation for studying development and repair is the CNS of the newborn opossum which, removed in its entirety, survives in culture for more than 1 week. In suitable medium, cells continue to divide, mature and reflex activity is maintained. Moreover, nerve fibers grow rapidly, reliably and extensively ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61141-3

    authors: Nicholls JG,Vischer H,Varga Z,Erulkar S,Saunders NR

    更新日期:1994-01-01 00:00:00

  • Molecular genetic approaches to puerperal psychosis.

    abstract::Puerperal psychosis, an episode of mania or psychosis precipitated by childbirth follows approximately one in 1000 deliveries. The evidence of clinical, outcome and genetic studies supports the hypothesis that the majority of puerperal psychotic episodes are manifestations of an affective disorder diathesis with a pue...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(01)33024-8

    authors: Jones I,Lendon C,Coyle N,Robertson E,Brockington I,Craddock N

    更新日期:2001-01-01 00:00:00

  • How the orbitofrontal cortex contributes to decision making - a view from neuroscience.

    abstract::In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review r...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)01306-5

    authors: Volz KG,von Cramon DY

    更新日期:2009-01-01 00:00:00

  • Transsaccadic memory for visual object detail.

    abstract::When we move our eyes around in real-world scenes, we typically have several peripheral previews of an object before we direct our eyes straight at the object. Numerous studies on transsaccadic memory have investigated whether there is any evidence for the integration of peripheral object information acquired presacca...

    journal_title:Progress in brain research

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0079-6123(02)40050-7

    authors: De Graef P,Verfaillie K

    更新日期:2002-01-01 00:00:00

  • Comparative anatomy of the hippocampal dentate gyrus in adult and developing rodents, non-human primates and humans.

    abstract::There has been substantial progress in our understanding of the hippocampus in the past 70 years. During this time, it has become clear that the hippocampus is not an olfactory-related structure alone, but plays critical roles in other functions that do not necessarily depend on olfaction, such as learning and memory....

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)63002-7

    authors: Seress L

    更新日期:2007-01-01 00:00:00

  • Methods to produce hyperthermia-induced brain dysfunction.

    abstract::The recent increase in the frequency and intensity of killer heat waves across the globe has aroused worldwide medical attention to exploring therapeutic strategies to attenuate heat-related morbidity and/or mortality. Death due to heat-related illnesses often exceeds >50% of heat victims. Those who survive are crippl...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)62010-4

    authors: Sharma HS

    更新日期:2007-01-01 00:00:00

  • Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome.

    abstract::Early intervention and environmental optimization have been central to management of Down syndrome (DS) and much of current treatment is still focused in strategies that involve early education plans. This approach has provided significant improvements for Down syndrome but it is not providing a full success. The disc...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2019.11.001

    authors: Martínez Cué C,Dierssen M

    更新日期:2020-01-01 00:00:00

  • Anthropology and cultural neuroscience: creating productive intersections in parallel fields.

    abstract::Partly due to the failure of anthropology to productively engage the fields of psychology and neuroscience, investigations in cultural neuroscience have occurred largely without the active involvement of anthropologists or anthropological theory. Dramatic advances in the tools and findings of social neuroscience have ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(09)17803-2

    authors: Brown RA,Seligman R

    更新日期:2009-01-01 00:00:00

  • Insights from comparative research on social and cultural learning.

    abstract::Social cognitive skills play a crucial role in human life, and have allowed us to reach a unique level of behavioral and cultural complexity. However, many nonhuman species also show a complex understanding of the social world. Building on theories of human social development, we will follow the emergence of cultural ...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2020.05.008

    authors: Cacchione T,Amici F

    更新日期:2020-01-01 00:00:00

  • Somatostatin analogues: treatment of pituitary and neuroendocrine tumors.

    abstract::This chapter summarizes the most recent data on the use of the somatostatin analogues (SSAs), octreotide (OCT) and lanreotide for the treatment of patients with pituitary and neuroendocrine tumors (NETs). These two analogues have a high affinity for somatostatin receptor (SSR) sub-types 2 and 5. The major indications ...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(10)82012-6

    authors: Colao A,Faggiano A,Pivonello R

    更新日期:2010-01-01 00:00:00

  • Dynamics of thalamo-cortical network oscillations and human perception.

    abstract::There is increasing evidence that human cognitive functions can be addressed from a robust neuroscience perspective. In particular, the distributed coherent electrical properties of central neuronal ensembles are considered to be a promising avenue of inquiry concerning global brain functions. The intrinsic oscillator...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)50010-4

    authors: Ribary U

    更新日期:2005-01-01 00:00:00

  • Vasopressin binding sites in the central nervous system: distribution and regulation.

    abstract::High affinity binding sites for vasopressin (VP) are widely distributed within the rat brain and spinal cord. Since their presence is associated with neuronal sensitivity to VP application, their anatomical distribution maps structures which could be activated by endogenous VP. Interestingly, marked species-related di...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61561-7

    authors: Tribollet E,Arsenijevic Y,Barberis C

    更新日期:1998-01-01 00:00:00

  • General principles of rhythmogenesis in central pattern generator networks.

    abstract::The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/B978-0-444-53613-6.00014-9

    authors: Harris-Warrick RM

    更新日期:2010-01-01 00:00:00

  • The frontal eye field as a prediction map.

    abstract::Predictive processes are widespread in the motor and sensory areas of the primate brain. They enable rapid computations despite processing delays and assist in resolving noisy, ambiguous input. Here we propose that the frontal eye field, a cortical area devoted to sensorimotor aspects of eye movement control, implemen...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(08)00656-0

    authors: Crapse TB,Sommer MA

    更新日期:2008-01-01 00:00:00

  • Specificity in the organization of the autonomic nervous system: a basis for precise neural regulation of homeostatic and protective body functions.

    abstract::Experimental investigations of the lumbar sympathetic outflow to skin, skeletal muscle and viscera and the thoracic sympathetic outflow to the head and neck have shown that each target organ and tissue is supplied by one or two separate pathways which consists of sets of pre- and postganglionic neurons with distinct p...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)62150-0

    authors: Jänig W,Häbler HJ

    更新日期:2000-01-01 00:00:00

  • Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma.

    abstract::Glaucoma is a visual disorder characterized by progressive loss of retinal ganglion cells (RGCs), which is often associated with high intraocular pressure. However, mechanisms of RGC death in glaucoma still remain a mystery. Two theories have been proposed as pathogeneses of glaucoma: mechanical and vascular. We demon...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)01134-5

    authors: Seki M,Lipton SA

    更新日期:2008-01-01 00:00:00

  • Progressive increases of protein synthesis in the circumventricular organs during chronic dehydration in rats.

    abstract::The quantitative autoradiographic method with L-(35S)methionine was applied to investigate the effect of chronic dehydration on rates of protein synthesis in circumventricular organs (CVOs). Water deprivation for 1, 2 and 3 days causes progressive increases of protein synthesis in the subfornical organ (SFO), the area...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)62363-8

    authors: Lepetit P,Grange E,Gay N,Bobillier P

    更新日期:1992-01-01 00:00:00

  • Cortical and brainstem control of locomotion.

    abstract::While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(03)43025-2

    authors: Drew T,Prentice S,Schepens B

    更新日期:2004-01-01 00:00:00

  • Development of brain mechanisms for visual global processing and object segmentation.

    abstract::Objects have specific cognitive attributes, elicit particular visuo-motor responses, and require visual processes beyond primary visual cortex to combine information over extended regions as a basis for the segmentation and integration of visual objects. As well as segmentation, the assignment of region boundaries to ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)64008-4

    authors: Braddick O,Atkinson J

    更新日期:2007-01-01 00:00:00