Abstract:
:This chapter summarizes the most recent data on the use of the somatostatin analogues (SSAs), octreotide (OCT) and lanreotide for the treatment of patients with pituitary and neuroendocrine tumors (NETs). These two analogues have a high affinity for somatostatin receptor (SSR) sub-types 2 and 5. The major indications of these compounds are GH- and TSH-secreting pituitary adenomas, secreting NETs and non-functioning NETs in progression. Pasireotide is a new analogue, with a receptor pattern different from previous analogues since it binds with high affinity to SSR types 1, 2, 3 and 5. This analogue will be available to treat patients with ACTH-secreting adenomas in a short time. A recent study has also demonstrated a beneficial effect of OCT long-acting release in patients with non-functioning NETs independently from their progression status. These data open the treatment with SSAs in all NET patients.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Colao A,Faggiano A,Pivonello Rdoi
10.1016/S0079-6123(10)82012-6subject
Has Abstractpub_date
2010-01-01 00:00:00pages
281-94eissn
0079-6123issn
1875-7855pii
S0079-6123(10)82012-6journal_volume
182pub_type
杂志文章abstract::Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activation using a mouse model of ocular hypertension (OHT) at the onset of aging...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2020.05.024
更新日期:2020-01-01 00:00:00
abstract::In recent years the scientific community has come to appreciate that the early cortical representations for visually guided arm movements are probably coded in a visual frame, i.e. relative to retinal landmarks. While this scheme accounts for many behavioral and neurophysiological observations, it also poses certain p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)40060-X
更新日期:2002-01-01 00:00:00
abstract::The ability to form tenable hypotheses regarding the neurobiological basis of normative functions as well as mechanisms underlying neurodegenerative and neuropsychiatric disorders is often limited by the highly complex brain circuitry and the cellular and molecular mosaics therein. The brain is an intricate structure ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)58002-1
更新日期:2006-01-01 00:00:00
abstract::Elucidation of the molecular basis of mammalian circadian rhythms has progressed dramatically in recent years through the characterization of mouse mutants. With the implementation of numerous mouse genetics programs, comprehensive sets of mutations in genes affecting circadian output measures have been generated. Alt...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-59427-3.00015-0
更新日期:2012-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most prevalent form of neurodegeneration; however, therapies to prevent or treat AD are inadequate. Amyloid-beta (Abeta) protein accrues in cortical senile plaques, one of the key neuropathological hallmarks of AD, and is elevated in brains of early onset AD patients in a small number o...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17506-4
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abstract::The organization of key molecules at glutamatergic synapses in the rat cerebellar cortex as analyzed by high resolution immunocytochemical techniques using gold particles as markers. The distinct compartmentation of glutamate and glutamine was consistent with biochemical data indicating an active role of glia in the r...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63360-9
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abstract::Various growth factors are present in the hippocampal formation and appear responsible for the prominent plasticity of this brain area. Although hormone-like growth-promoting polypeptides are the best known, recent studies emphasize the importance in the growth response of molecules such as laminin proteoglycans, neur...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
pub_type: 历史文章,杂志文章
doi:10.1016/B978-0-444-63273-9.00004-6
更新日期:2013-01-01 00:00:00
abstract::The impact of spinal cord injury on an individual's gastrointestinal tract function is often poorly understood by the general public and also by those involved with persons with spinal cord injury. This chapter reviews the anatomy, physiology and function of the gastrointestinal tract, with particular emphasis on neur...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)52021-1
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)45007-3
更新日期:2004-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62658-8
更新日期:1990-01-01 00:00:00
abstract::When discrepant stimuli are presented to each eye and fusion is impossible, perception spontaneously oscillates between the two patterns (binocular rivalry). Functional MRI (fMRI) research identified a frontoparietal network in the right hemisphere associated with perceptual transitions, and it has been proposed that ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(06)55013-7
更新日期:2006-01-01 00:00:00
abstract::Intracellular recordings from 103 photoreceptors in the excised pineal body of adult trouts were obtained by using single electrode current- and voltage-clamp techniques. The photoresponses to brief flashes showed the same polarity but a slower time course than those previously recorded from retinal photoreceptors of ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)60352-0
更新日期:1993-01-01 00:00:00
abstract::While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)43025-2
更新日期:2004-01-01 00:00:00
abstract::Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00666-3
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-63287-6.00005-1
更新日期:2013-01-01 00:00:00
abstract::Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)30018-3
更新日期:2001-01-01 00:00:00
abstract::The ecological dynamics approach offers new insights to understand how athlete nervous systems are embedded within the body-environment system in sport. Cognitive neuroscience focuses on the neural bases of athlete behaviors in terms of perceptual, cognitive, and motor functions defined within specific brain structure...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2017.06.001
更新日期:2017-01-01 00:00:00
abstract::The main topic of this overview is an analysis of the concepts of phase and synchrony, as used in neurophysiology, in their various meanings. A number of notions related to the concepts of phase and synchrony, which are incorporated in contemporary neurophysiology, particularly in the domain of neuro-cognitive physiol...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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abstract::Much of the past research on how reward motivation and emotional information influence brain and behavior has been conducted separately. Recently, a few behavioral and brain imaging studies have investigated how reward and emotional information co-jointly impact brain and behavior. The present chapter reviews findings...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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abstract::Studies in vitro and in other disease states where excitotoxicity is believed to be important have demonstrated that mitochondrial function is a critical determinant of cell death, reflecting key roles in intracellular calcium homeostasis, energy production and oxidative stress. Central to this is the process of mitoc...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
abstract::Schwann cells (SCs), when implanted in the injured spinal cord, support regeneration of axons, myelinate or ensheathe regenerated axons in a normal way, reduce cyst formation in the injured tissue, reduce secondary damage of tissue around the initial injury site, and modestly improve limb movements. If SC transplantat...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
abstract::Metabolic status varies predictably on a daily and seasonal basis in order to adapt to the cyclical environment. The hypothalamic circadian pacemaker of the suprachiasmatic nuclei (SCN) co-ordinates these metabolic cycles. Circadian timing is based upon a transcriptional/post-translational negative feedback loop invol...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)53015-8
更新日期:2006-01-01 00:00:00
abstract::Motor control is defined as the process of restricting the output of the motor nervous system so that meaningful and coordinated behavior ensues. The high dimensionality of the computation underlying motor control is presented and a simplifying framework is outlined. Evidence that movements are performed non-continuou...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63380-4
更新日期:1997-01-01 00:00:00
abstract::Selective neuronal loss following status epilepticus was first described just under 100 years ago. The acute pathology following status epilepticus was shown to be 'ischemic cell change' and was assumed to arise through hypoxia/ischemia. Less than 30 years ago it was proposed, from experiments in primates, that the se...
journal_title:Progress in brain research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/S0079-6123(02)35003-9
更新日期:2002-01-01 00:00:00
abstract::Epileptic seizures cause dynamic, reversible changes in brain function and are often associated with loss of consciousness. Of all seizure types, absence seizures lead to the most selective deficits in consciousness, with relatively little motor or other manifestations. Impaired consciousness in absence seizures is no...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)50020-7
更新日期:2005-01-01 00:00:00
abstract::Most people are experts in face recognition. We propose that the special status of this particular body part in telling individuals apart is the result of a developmental process that heavily biases human infants and children to attend towards the eyes of others. We review the evidence supporting this proposal, includ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)64018-7
更新日期:2007-01-01 00:00:00
abstract::The subiculum gives rise to the majority of hippocampal projections to various telencephalic and diencephalic structures. Previously, these projections have been described using anterograde tracing with radioactively labeled amino acids. As part of an ongoing detailed analysis of the connectivity of the hippocampal re...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)61240-6
更新日期:1990-01-01 00:00:00
abstract::The development of atherosclerotic cardiovascular disease is a common comorbidity in patients with the metabolic syndrome, a concurrence of cardiovascular risk factors in one individual. While multiple growth factors and adipokines are identified in atherosclerotic lesions, as well as neurotrophins implicated in both ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)46018-4
更新日期:2004-01-01 00:00:00