Somatostatin analogues: treatment of pituitary and neuroendocrine tumors.

Abstract:

:This chapter summarizes the most recent data on the use of the somatostatin analogues (SSAs), octreotide (OCT) and lanreotide for the treatment of patients with pituitary and neuroendocrine tumors (NETs). These two analogues have a high affinity for somatostatin receptor (SSR) sub-types 2 and 5. The major indications of these compounds are GH- and TSH-secreting pituitary adenomas, secreting NETs and non-functioning NETs in progression. Pasireotide is a new analogue, with a receptor pattern different from previous analogues since it binds with high affinity to SSR types 1, 2, 3 and 5. This analogue will be available to treat patients with ACTH-secreting adenomas in a short time. A recent study has also demonstrated a beneficial effect of OCT long-acting release in patients with non-functioning NETs independently from their progression status. These data open the treatment with SSAs in all NET patients.

journal_name

Prog Brain Res

authors

Colao A,Faggiano A,Pivonello R

doi

10.1016/S0079-6123(10)82012-6

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

281-94

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(10)82012-6

journal_volume

182

pub_type

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