Abstract：
:Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement response suggest that this type of activity is not simply related to the forthcoming motor action, but rather reflects a correct match between the visual cue and the motor response. The existence of such activity further supports the notion that the motor system operates in a parallel mode of processing, so that even during early stages of motor processing multiple centers are activated regardless of their anatomical distance from muscles. The firing properties of spinal INs during the performance of the task seem to differ from the comparable properties of motor cortical cells. Spinal INs fire in a highly regular manner--their CV is substantially lower than the observed CV of cortical cells. Also, although neighboring cells tend to have similar response properties, the frequency of significant correlation is lower than for cortical cells and the anatomical extent of the correlation seems to be narrower. The similarity and differences between cortical and spinal cells in terms of response and firing properties suggests that while both type of cells are active in parallel throughout the behavioral phases of the motor task, each may operate in a different mode of information processing.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Prut Y,Perlmutter SI,Fetz EEdoi
10.1016/s0079-6123(01)30018-3subject
Has Abstractpub_date
2001-01-01 00:00:00pages
267-78eissn
0079-6123issn
1875-7855pii
S0079-6123(01)30018-3journal_volume
130pub_type
杂志文章,评审abstract：:Since the discovery of nerve growth factor (NGF) in the 1950s and brain-derived neurotrophic factor (BDNF) in the 1980s, a great deal of evidence has mounted for the roles of neurotrophins (NGF; BDNF; neurotrophin-3, NT-3; and neurotrophin-4/5, NT-4/5) in development, physiology, and pathology. BDNF in particular has ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(07)63022-2
更新日期：2007-01-01 00:00:00
abstract：:1. Alzheimer's disease is a multifactorial disease in which age and APOE-epsilon 4 are important risk factors. Various mutations and even viral infections such as herpes simplex (Itzhaki et al., 1997) may play an additional role. 2. The neuropathological hallmarks of Alzheimer's disease (AD), i.e. amorphous plaques, n...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)64027-3
更新日期：1998-01-01 00:00:00
abstract：:The recent increase in the frequency and intensity of killer heat waves across the globe has aroused worldwide medical attention to exploring therapeutic strategies to attenuate heat-related morbidity and/or mortality. Death due to heat-related illnesses often exceeds >50% of heat victims. Those who survive are crippl...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
abstract：:In mammals, the circadian system is composed of the central clock in the hypothalamic suprachiasmatic nuclei and of peripheral clocks that are located in other neural structures and in cells of the peripheral tissues and organs. In adults, the system is hierarchically organized so that the central clock provides the o...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
abstract：:The impact of spinal cord injury on an individual's gastrointestinal tract function is often poorly understood by the general public and also by those involved with persons with spinal cord injury. This chapter reviews the anatomy, physiology and function of the gastrointestinal tract, with particular emphasis on neur...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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journal_title：Progress in brain research
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更新日期：2002-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：1996-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：Progress in brain research
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更新日期：2009-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2020.05.008
更新日期：2020-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)60352-0
更新日期：1993-01-01 00:00:00
abstract：:Quantitative models of the oculomotor plant and control of the saccadic eye movement system are presented in this chapter. Oculomotor plant models described here are linear, including a second-order model by Westheimer (1954), Bahill et al. (1980) and Enderle et al. (2000). The model of the saccade generator is initia...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)61801-4
更新日期：1995-01-01 00:00:00
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journal_title：Progress in brain research
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更新日期：2008-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most prevalent form of neurodegeneration; however, therapies to prevent or treat AD are inadequate. Amyloid-beta (Abeta) protein accrues in cortical senile plaques, one of the key neuropathological hallmarks of AD, and is elevated in brains of early onset AD patients in a small number o...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
abstract：:The present study involves the effects on corticotropin (ACTH) release of neuro- and thymoleptic tricyclic antidepressant compounds (TrcACs: chlorpromazine, promethazine, haloperidol, imipramine, amitriptyline) and their interactions with lysine-8-vasopressin (LVP) and corticosterone (B). As an in vitro model, 14-day ...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)62322-5
更新日期：1992-01-01 00:00:00
abstract：:Based on a review of anatomical and physiological findings, we suggest that the hippocampus may be viewed as a positive feedback device (autoassociator), which is capable of modifying the activity of the neocortical neurons. We examine the three-dimensional organization of evoked and spontaneous physiological patterns...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)61255-8
更新日期：1990-01-01 00:00:00
abstract：:The results from the language studies taken as a whole point to different developmental time courses and developmental vulnerabilities of aspects of grammatical and semantic/lexical processing. They thus provide support for conceptions of language that distinguish these subprocesses within language. Similarly, followi...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
abstract：:Neuronal activity increases synthesis of brain-derived neurotrophic factor (BDNF) mRNA in vivo and in vitro. We have investigated the pathways through which neuronal activity stimulated by kainic acid regulates BDNF mRNA levels in cultured hippocampal neurons and transgenic mice. Kainic acid induced the transcription ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)64007-8
更新日期：1998-01-01 00:00:00
abstract：:The following chapter offers an overview of results of experimental studies conducted among healthy individuals examining the effects of acute administration of Δ9-THC and other cannabinoids, alone or in combination, on brain function and behavior, also as a function of previous cannabis exposure. In light of their me...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2018.08.010
更新日期：2018-01-01 00:00:00
abstract：:Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending (sensory) pathways and descending (motor) nerve pathways without the perspective of complete functional recovery. Future spinal cord repair strategies should comprise a multi-factorial approach addressing several issues, includin...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(03)46029-9
更新日期：2004-01-01 00:00:00
