Central effects of tricyclic compounds on the endocrine system--an in vitro study.

Abstract:

:The present study involves the effects on corticotropin (ACTH) release of neuro- and thymoleptic tricyclic antidepressant compounds (TrcACs: chlorpromazine, promethazine, haloperidol, imipramine, amitriptyline) and their interactions with lysine-8-vasopressin (LVP) and corticosterone (B). As an in vitro model, 14-day monolayer pituitary cell cultures of Wistar rats were employed. The ACTH concentrations of the supernatant media were measured by radioimmunoassay. TrcACs augmented ACTH release; their combination with LVP, however, did not result in further stimulation; moreover, when combined with TrcACs + LVP, B did not inhibit, but rather paradoxically increased their ACTH-releasing action. As none of these phenomena were followed by relevant changes in intracellular cyclic adenosine monophosphate content, the mechanism of action may be proposed to involve a protein kinase C route.

journal_name

Prog Brain Res

authors

Julesz J,Gálfi M,Molnár J,Vecsernyés M

doi

10.1016/s0079-6123(08)62322-5

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

89-92

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(08)62322-5

journal_volume

91

pub_type

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