Non-metabolic and metabolic factors causing lactational anestrus: rat models uncovering the neuroendocrine mechanism underlying the suckling-induced changes in the mother.

Abstract:

:Follicular development and ovulation are strongly inhibited during lactation. Administration of a high dose of estrogen induces luteinizing hormone (LH) surges in ovariectomized lactating rats, suggesting that brain mechanisms regulating cyclic LH release remain intact in lactating mothers. On the other hand, tonic LH release is profoundly suppressed in lactating rats. This suggests that lactational anestrus is mainly due to suppression of the mechanism regulating pulsatile gonadotropin-releasing hormone secretion in the hypothalamus, which is responsible for follicular development and steroid production. Both metabolic and non-metabolic factors are involved in suppressing pulsatile LH secretion throughout lactation in rats. During the first half of lactation, pulsatile LH secretion is strongly suppressed, even if milk production is attenuated by pharmacological blockade of prolactin secretion in ovariectomized lactating rats. Pulsatile LH release quickly recovers by removing pups or blocking neuronal input by hypothalamic deafferentation during the period. These data suggest that the suckling stimulus itself is responsible for suppression of LH release during the first half of lactation. During the second half of lactation, negative energy balance, which is caused by the milk production, appears to play a dominant role in suppressing LH secretion. Blockade of milk production by inhibiting prolactin release causes a gradual increase in LH release even if the vigorous suckling stimulus by foster pups remains. In conclusion, the suckling stimulus itself predominantly suppresses LH pulses during the first half of lactation and metabolic factors take over the role of the suckling stimulus during the second half of lactation.

journal_name

Prog Brain Res

authors

Tsukamura H,Maeda K

doi

10.1016/s0079-6123(01)33014-5

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

187-205

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(01)33014-5

journal_volume

133

pub_type

杂志文章,评审
  • Circannual rhythm in the varied carpet beetle, Anthrenus verbasci.

    abstract::Although circannual rhythms controlling different physiological processes and various aspects of behavior have been reported in numerous organisms, our understanding of the underlying biological mechanisms is still quite limited. We examined the mechanisms controlling the circannual pupation rhythm of the varied carpe...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-59427-3.00025-3

    authors: Miyazaki Y,Nisimura T,Numata H

    更新日期:2012-01-01 00:00:00

  • Molecular substrates of plasticity in the developing visual cortex.

    abstract::Ocular dominance plasticity may be the paradigmatic in vivo model of activity-dependent plasticity. More than four decades of intense research has delineated the network-level rules that govern synaptic change in this model. The recent characterization of a murine model for ocular dominance plasticity has facilitated ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(04)47008-3

    authors: Taha SA,Stryker MP

    更新日期:2005-01-01 00:00:00

  • Neuronal responses to injury and aging: lessons from animal models.

    abstract::Alzheimer's disease (AD), the most common type of adult-onset dementia, is characterized by a variety of brain abnormalities, including degeneration of certain populations of nerve cells, alterations in the neuronal cytoskeleton, and the abnormal deposition of amyloid within brain parenchyma. Pathogenetic processes th...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63186-6

    authors: Price DL,Koo EH,Sisodia SS,Martin LJ,Koliatsos VE,Muma NA,Walker LC,Cork LC

    更新日期:1990-01-01 00:00:00

  • Physiological properties and afferent connections of the locus coeruleus and adjacent tegmental neurons involved in the generation of paradoxical sleep in the cat.

    abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63798-x

    authors: Sakai K

    更新日期:1991-01-01 00:00:00

  • Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?

    abstract::The development of atherosclerotic cardiovascular disease is a common comorbidity in patients with the metabolic syndrome, a concurrence of cardiovascular risk factors in one individual. While multiple growth factors and adipokines are identified in atherosclerotic lesions, as well as neurotrophins implicated in both ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(03)46018-4

    authors: Chaldakov GN,Fiore M,Stankulov IS,Manni L,Hristova MG,Antonelli A,Ghenev PI,Aloe L

    更新日期:2004-01-01 00:00:00

  • Brain extracellular matrix meets COST--matrix for European research networks.

    abstract::Today's researchers are faced with a change from curiosity-driven to mandate-driven research. These two approaches are well combined within scientific networks (Actions) supported by the European Cooperation in Science and Technology (COST) program. The functioning of COST Actions, although directed only to networking...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-63486-3.09999-0

    authors: Gajović S,Pochet R

    更新日期:2014-01-01 00:00:00

  • General principles of rhythmogenesis in central pattern generator networks.

    abstract::The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/B978-0-444-53613-6.00014-9

    authors: Harris-Warrick RM

    更新日期:2010-01-01 00:00:00

  • Spatial organization of physiological activity in the hippocampal region: relevance to memory formation.

    abstract::Based on a review of anatomical and physiological findings, we suggest that the hippocampus may be viewed as a positive feedback device (autoassociator), which is capable of modifying the activity of the neocortical neurons. We examine the three-dimensional organization of evoked and spontaneous physiological patterns...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61255-8

    authors: Buzsáki G,Chen LS,Gage FH

    更新日期:1990-01-01 00:00:00

  • Genetics of chronic tinnitus.

    abstract::Susceptibility to chronic tinnitus is highly variable and of particular interest when it comes to defining strategies for prevention and treatment. While several rare monogenic disorders have been described that are associated with tinnitus, the genetic underpinnings of the more common forms of the syndrome are still ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66014-2

    authors: Sand PG,Langguth B,Kleinjung T,Eichhammer P

    更新日期:2007-01-01 00:00:00

  • Antidepressants for treatment of tinnitus.

    abstract::Antidepressants are commonly prescribed for tinnitus. Research thus far provides some support for that treatment, but the literature also raises concerns because tinnitus is a side effect of antidepressant medication. In this chapter, four published double blind placebo-controlled trials of antidepressants for tinnitu...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66024-5

    authors: Robinson S

    更新日期:2007-01-01 00:00:00

  • Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways.

    abstract::Neuronal nitric oxide synthase (nNOS) participate in a variety of physiologic and pathologic processes in the nervous system. nNOS was originally felt to be a constitutively expressed enzyme, but recent observations suggest that its levels are dynamically controlled in response to neuronal development, plasticity and ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63196-9

    authors: Dawson TM,Sasaki M,Gonzalez-Zulueta M,Dawson VL

    更新日期:1998-01-01 00:00:00

  • Circadian timing in health and disease.

    abstract::Metabolic status varies predictably on a daily and seasonal basis in order to adapt to the cyclical environment. The hypothalamic circadian pacemaker of the suprachiasmatic nuclei (SCN) co-ordinates these metabolic cycles. Circadian timing is based upon a transcriptional/post-translational negative feedback loop invol...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)53015-8

    authors: Maywood ES,O'Neill J,Wong GK,Reddy AB,Hastings MH

    更新日期:2006-01-01 00:00:00

  • Tinnitus and pain.

    abstract::Tinnitus has many similarities with the symptoms of neurological disorders such as paresthesia and central neuropathic pain. There is considerable evidence that the symptoms and signs of some forms of tinnitus and central neuropathic pain are caused by functional changes in specific parts of the central nervous system...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66004-X

    authors: Møller AR

    更新日期:2007-01-01 00:00:00

  • Cajal's prophetic functional considerations on respiratory reflexes: new questions about old answers.

    abstract::In the "Histology of the Nervous System" (Histologie, Spanish edition, 1899, 1904; French translation, 1909, 1911; all citations are from the American translation, 1995) Cajal did not only describe the origins and central pathways of cranial nerves but his detailed observations led him to numerous conclusions about th...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(02)36036-9

    authors: Schwarzacher SW

    更新日期:2002-01-01 00:00:00

  • Training attention for conscious non-REM sleep: The yogic practice of yoga-nidrā and its implications for neuroscience research.

    abstract::The study of consciousness within cognitive neuroscience has been dominated in recent years by investigations originating from collaborations between neuroscientific investigators and Buddhist meditation practitioners. The results have been remarkable, particularly when quantitative and qualitative research methods ha...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2018.10.016

    authors: Parker S

    更新日期:2019-01-01 00:00:00

  • The suprachiasmatic nucleus-paraventricular nucleus interactions: a bridge to the neuroendocrine and autonomic nervous system.

    abstract::Vasopressin (VP) is one of the principal neurotransmitters of the suprachiasmatic nucleus (SCN). By means of anatomical, physiological and electrophysiological techniques we have demonstrated that VP containing pathways from the SCN serve to affect neuroendocrine and 'autonomic' neurons in the paraventricular nucleus....

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61581-2

    authors: Buijs RM,Hermes MH,Kalsbeek A

    更新日期:1998-01-01 00:00:00

  • Evolution and development of handedness: An Evo-Devo approach.

    abstract::Hand preference is a sensorimotor skill whose development both reflects and promotes the development of hemispheric lateralization for manual and cognitive functions. Extensive comparative, crosscultural, and paleoanthropological evidence demonstrates the prevalence of limb lateralized preferences across vertebrate sp...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2018.06.007

    authors: Michel GF,Babik I,Nelson EL,Campbell JM,Marcinowski EC

    更新日期:2018-01-01 00:00:00

  • Stimulus-driven changes in sensorimotor behavior and neuronal functional connectivity application to brain-machine interfaces and neurorehabilitation.

    abstract::Normal brain function requires constant adaptation as an organism interacts with the environment and learns to associate important sensory stimuli with appropriate motor actions. Neurological disorders may disrupt these learned associations, potentially requiring new functional pathways to be formed to replace the los...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53355-5.00006-3

    authors: Rebesco JM,Miller LE

    更新日期:2011-01-01 00:00:00

  • Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy.

    abstract::GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or function of PV INs has been associated with epilepsy in various animal ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2016.04.012

    authors: Jiang X,Lachance M,Rossignol E

    更新日期:2016-01-01 00:00:00

  • Buddha and the bridging relations.

    abstract::The chapter reviews a classical Indian model of consciousness found in the Abhidhamma, a collection of seven treatises in the Pali Canon Tipitaka. The model was based on observations made during advanced vipassana practice, a first-person method taught by the Buddha. The climax of the model consists in the elucidation...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)68020-0

    authors: Banerjee R

    更新日期:2008-01-01 00:00:00

  • Eventual sport performance level: What about the role of type of sport, perception of critical life events, and practice quality?

    abstract::The target article describes an interesting study, which provides some challenging findings regarding athletes' pathway to excellence. The suggested links between critical life events, need for success, personal characteristics, and eventual performance level make sense from a psychodynamic perspective. This commentar...

    journal_title:Progress in brain research

    pub_type: 评论,杂志文章

    doi:10.1016/bs.pbr.2017.02.004

    authors: Toering T

    更新日期:2017-01-01 00:00:00

  • Alterations of dopamine and serotonin transmission in schizophrenia.

    abstract::The present chapter outlines current thinking regarding serotonin and dopamine in schizophrenia. Each has individually been linked to theories regarding the illness' pathophysiology although the focus here is on their interactive role, a model that has driven drug development in the field for the last 10-15 years. Wit...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)00906-0

    authors: Remington G

    更新日期:2008-01-01 00:00:00

  • The psychosocial development of world-class athletes: Additional considerations for understanding the whole person and salience of adversity.

    abstract::In the target article, Hardy and colleagues provided an incisive analysis of retrospectively reported psychosocial factors associated with the development and careers of 32 former athletes from Olympic sports. They found that Super-Elite athletes ("serial" medal winners at major international championships, i.e., Worl...

    journal_title:Progress in brain research

    pub_type: 评论,杂志文章

    doi:10.1016/bs.pbr.2016.11.006

    authors: Gucciardi DF

    更新日期:2017-01-01 00:00:00

  • Development of cognitive and affective control networks and decision making.

    abstract::Cognitive control and decision making are two important research areas in the realm of higher-order cognition. Control processes such as interference control and monitoring in cognitive and affective contexts have been found to influence the process of decision making. Development of control processes follows a gradua...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/B978-0-444-62604-2.00018-6

    authors: Kar BR,Vijay N,Mishra S

    更新日期:2013-01-01 00:00:00

  • Neuroendocrine dysregulations in sexually abused children and adolescents: a systematic review.

    abstract::Several studies provided evidence for neuroendocrine dysregulations in adults with a history of child sexual abuse. This review focuses on neuroendocrine studies in sexually abused children and adolescents, dating from January 1, 1990 to January 1, 2007 and obtained from a systematic Medline Indexed literature search ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,meta分析

    doi:10.1016/S0079-6123(07)67028-9

    authors: Bicanic IA,Meijer M,Sinnema G,van de Putte EM,Olff M

    更新日期:2008-01-01 00:00:00

  • The active role of dendrites in the regulation of magnocellular neurosecretory cell behavior.

    abstract::The interactions of the dendritically released neuropeptides vasopressin and oxytocin with co-released neuroactive substances such as opioids and nitric oxide are reviewed. Endogenous opioids regulate magnocellular neurons at the level of the supraoptic nucleus and the relationship of dendritically released peptides a...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(02)39021-6

    authors: Ludwig M,Sabatier N,Dayanithi G,Russell JA,Leng G

    更新日期:2002-01-01 00:00:00

  • Cyclovergence evoked by up-down acceleration along longitudinal axis in humans.

    abstract::We present results of a study of torsional eye movements evoked by earth-vertical accelerations along the subject's longitudinal axis. The earth-vertical stimulus leads to a gravito-inertial acceleration vector that changes magnitude but not direction. It can therefore be viewed as a dynamic change of the gravity leve...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(08)00646-8

    authors: Olasagasti I,Bockisch CJ,Zee DS,Straumann D

    更新日期:2008-01-01 00:00:00

  • Generation of mouse mutants as tools in dissecting the molecular clock.

    abstract::Elucidation of the molecular basis of mammalian circadian rhythms has progressed dramatically in recent years through the characterization of mouse mutants. With the implementation of numerous mouse genetics programs, comprehensive sets of mutations in genes affecting circadian output measures have been generated. Alt...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/B978-0-444-59427-3.00015-0

    authors: Anand SN,Edwards JK,Nolan PM

    更新日期:2012-01-01 00:00:00

  • Anthropology and cultural neuroscience: creating productive intersections in parallel fields.

    abstract::Partly due to the failure of anthropology to productively engage the fields of psychology and neuroscience, investigations in cultural neuroscience have occurred largely without the active involvement of anthropologists or anthropological theory. Dramatic advances in the tools and findings of social neuroscience have ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(09)17803-2

    authors: Brown RA,Seligman R

    更新日期:2009-01-01 00:00:00

  • Serotonin modulates retinotectal and corticotectal convergence in the superior colliculus.

    abstract::A dense serotonin (5-HT)-containing projection to the superficial layers of the superior colliculus (SC) has been demonstrated in diverse mammalian species, but how 5-HT may affect visual signals within these laminae is largely unknown. This study undertook to investigate the distribution of 2 types of 5-HT receptors ...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)63320-8

    authors: Mooney RD,Huang X,Shi MY,Bennett-Clarke CA,Rhoades RW

    更新日期:1996-01-01 00:00:00