Abstract：
:Based on a review of anatomical and physiological findings, we suggest that the hippocampus may be viewed as a positive feedback device (autoassociator), which is capable of modifying the activity of the neocortical neurons. We examine the three-dimensional organization of evoked and spontaneous physiological patterns of the hippocampus and suggest rules how these patterns emerge during different behaviors from a hard-wired structural network. The high spatial coherence of theta activity is due to an external pacemaker, while the high synchrony of population bursts underlying hippocampal sharp waves is explained by the similar probability of recruitment of neurons by the burst-initiator cells along the whole extent of the hippocampus. We suggest that the burst-initiator cells are a group of CA3 neurons whose excitability is increased by a transient potentiation action of the neocortical activity during theta-concurrent exploratory behaviors. We hypothesize that sharp wave-concurrent population bursts result in a highly synchronous hippocampal output, converging preferentially on those entorhinal neurons which were instrumental in the creation of the burst-initiator neurons. The feedback action of population activity thus provides a selective mechanism for potentiation of connections between information-carrying neurons in the hippocampus and entorhinal cortex. The state-dependent operations of the anatomical hardware also point to the importance and advantage of studying the physiological activity of the intact brain.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Buzsáki G,Chen LS,Gage FHdoi
10.1016/s0079-6123(08)61255-8subject
Has Abstractpub_date
1990-01-01 00:00:00pages
257-68eissn
0079-6123issn
1875-7855pii
S0079-6123(08)61255-8journal_volume
83pub_type
杂志文章,评审abstract：:Studies with nicotine have, from the outset, been of fundamental importance for the elucidation of physiological mechanisms. However, many nicotinic cholinoreceptors do not appear to subserve a physiological role, at least within the present framework of knowledge. The main challenge in the immediate future is to dete...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)62461-9
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:Primary angle-closure glaucoma (PACG) is the leading cause of blindness in East Asia. The disease can be classified into primary angle-closure suspect, primary angle closure (PAC), and PACG. Pupil-block, anterior nonpupil-block (plateau iris and peripheral iris crowding), lens related and retrolenticular m...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)01104-7
更新日期：2008-01-01 00:00:00
abstract：:A neural-network module with attractor dynamics has been shown recently to be robust to stochastic noise in external and internal signals, and to converge rapidly onto an output signal that is an unbiased and efficient representation of the environment. We suggest here a modular network architecture with attractor dyn...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)65025-5
更新日期：2007-01-01 00:00:00
abstract：:Retinogeniculate connections are one of the most striking examples of connection specificity within the visual pathway. In almost every connection there is one dominant afferent cell per geniculate cell, and both afferent and geniculate cells have very similar receptive fields. The remarkable specificity and strength ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)54001-4
更新日期：2006-01-01 00:00:00
abstract：:Cerebral malformations are best understood as abnormal tissue morphogenesis in the context of disorders of ontogenesis. In neuroembryology, the timing of onset and duration of abnormal genetic expression and neurodevelopmental processes are primordial and must always be assessed, regardless whether the dysgenesis is p...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-63326-2.00010-7
更新日期：2014-01-01 00:00:00
abstract：:In vivo functional imaging has provided objective evidence for the integration and function of nigral grafts in the brains of patients with Parkinson's disease. Clinical trials with the use of positron emission tomography have shown that transplants of human dopamine-rich fetal ventral mesencephalic tissue can survive...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-59575-1.00009-0
更新日期：2012-01-01 00:00:00
abstract：:Predictive processes are widespread in the motor and sensory areas of the primate brain. They enable rapid computations despite processing delays and assist in resolving noisy, ambiguous input. Here we propose that the frontal eye field, a cortical area devoted to sensorimotor aspects of eye movement control, implemen...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)00656-0
更新日期：2008-01-01 00:00:00
abstract：:Paired organotypic explants from rat occipital cortex were cultured for up to three weeks in the presence of selective blockers of amino acid receptor blockers, during which period spontaneous action potential generation was monitored electrophysiologically. In contrast to isolated explants (Corner, M.A., van Pelt, J....
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(04)47018-6
更新日期：2005-01-01 00:00:00
abstract：:Recent eye-tracking research has revealed that spoken language can guide eye gaze very rapidly (and closely time-locked to the unfolding speech) toward referents in the visual world. We discuss whether, and to what extent, such language-mediated eye movements are automatic rather than subject to conscious and controll...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-62604-2.00008-3
更新日期：2013-01-01 00:00:00
abstract：:The cytoarchitecture and the histochemistry of nucleus prepositus hypoglossi and its afferent and efferent connections to oculomotor structures are described. The functional significance of the afferent connections of the nucleus is discussed in terms of current knowledge of the firing behavior of prepositus neurons i...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(05)51007-0
更新日期：2006-01-01 00:00:00
abstract：:Schwann cells (SCs), when implanted in the injured spinal cord, support regeneration of axons, myelinate or ensheathe regenerated axons in a normal way, reduce cyst formation in the injured tissue, reduce secondary damage of tissue around the initial injury site, and modestly improve limb movements. If SC transplantat...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-59544-7.00014-7
更新日期：2012-01-01 00:00:00
abstract：:Treatment of refractory PD with autologous adrenal medullary implants utilizing two-stage surgery warrants further investigation. This transplantation technique is associated with prolonged transplant area BBB disruption which may require a change in medical treatment strategies including the withdrawal of peripheral ...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)62658-8
更新日期：1990-01-01 00:00:00
abstract：:Elucidation of the molecular basis of mammalian circadian rhythms has progressed dramatically in recent years through the characterization of mouse mutants. With the implementation of numerous mouse genetics programs, comprehensive sets of mutations in genes affecting circadian output measures have been generated. Alt...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-59427-3.00015-0
更新日期：2012-01-01 00:00:00
abstract：:Cognitive control and decision making are two important research areas in the realm of higher-order cognition. Control processes such as interference control and monitoring in cognitive and affective contexts have been found to influence the process of decision making. Development of control processes follows a gradua...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-62604-2.00018-6
更新日期：2013-01-01 00:00:00
abstract：:Findings on nonprimate mammals place the issue of mother-infant lateralized relations in a broader context, demonstrating that humans are one of many species showing this feature. The remarkable interspecies consistency in the direction of lateralization points to a continuity between lateralized mother-infant interac...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2018.06.003
更新日期：2018-01-01 00:00:00
abstract：:Characteristic features of autism include atypical social perception and social-communication skills, and atypical visual attention, alongside rigid and repetitive thinking and behavior. Debate has focused on whether the later emergence of atypical social skills is a consequence of attention problems early in life, or...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53884-0.00025-7
更新日期：2011-01-01 00:00:00
abstract：:Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(01)30018-3
更新日期：2001-01-01 00:00:00
abstract：:The effects of endogenous metabolites of the neuropeptide vasopressin (VP) in behavioural tests led to the hypothesis that VP metabolites have a more selective function than VP. In contrast to VP, no peripheral effects have been found thus far with VP metabolites and their function seems to be associated with memory-r...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)61591-5
更新日期：1998-01-01 00:00:00
abstract：:We developed a theoretical framework for studying coordination strategies in standing posture. The framework consists of a musculoskeletal model of the human lower extremity in the sagittal plane and a technique to visualize, geometrically, how constraints internal and external to the body affect movement. The set of ...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)62294-3
更新日期：1993-01-01 00:00:00
abstract：:Using alternatively labelled (-)-deprenyl (3H label in the ring and 14C in the propargyl group) the distribution of the compound was studied in 15 brain regions and the plasma of rats over a period of 96 h, after oral administration of 1.5 mg/kg of (-)-deprenyl. The compound is rapidly absorbed (within 15-30 min) from...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)61211-x
更新日期：1995-01-01 00:00:00
abstract：:The visual system is tied to the retina. Because the eyes move in the orbit, and the head moves on the body, accurate location of an object in extrapersonal space cannot simply result from a visual signal. Instead, the retinal signal must be combined with an estimate of where the eyes are in the orbit, and where the h...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)00606-7
更新日期：2008-01-01 00:00:00
abstract：:The results from the language studies taken as a whole point to different developmental time courses and developmental vulnerabilities of aspects of grammatical and semantic/lexical processing. They thus provide support for conceptions of language that distinguish these subprocesses within language. Similarly, followi...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(02)38078-6
更新日期：2002-01-01 00:00:00
abstract：:What are the building blocks of our visual representations? Whatever we look at, the things we see will have some feature variability: even snow is not purely white but has a range of shades of white. However, in most studies investigating visual perception, homogeneous displays with all stimuli having a very limited ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2017.07.001
更新日期：2017-01-01 00:00:00
abstract：:Sex hormone effects on hypothalamic neurons have been worked out to a point where receptor mechanisms are relatively well understood, a neural circuit for a sex steroid-dependent behavior has been determined, and several functional genomic regulations have been discovered and conceptualized. With that knowledge in han...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)58012-4
更新日期：2006-01-01 00:00:00
abstract：:During walking, an increase in speed is accompanied by a decrease in the stance phase duration while the swing phase remains relatively invariant. By definition, the rhythm generator in the lumbar spinal cord controls cycle period, phase durations, and phase transitions. Our first aim was to determine if this asymmetr...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53825-3.00007-3
更新日期：2011-01-01 00:00:00
abstract：:Human evolution was marked by an extraordinary increase in total brain size relative to body size. While it is certain that increased encephalization is an important factor contributing to the origin of our species-specific cognitive abilities, it is difficult to disentangle which aspects of human neural structure and...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53860-4.00011-8
更新日期：2012-01-01 00:00:00
abstract：:Neurons in the midbrain superior colliculus (SC) have the ability to integrate information from different senses to profoundly increase their sensitivity to external events. This not only enhances an organism's ability to detect and localize these events, but to program appropriate motor responses to them. The surviva...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53752-2.00007-2
更新日期：2011-01-01 00:00:00
abstract：:The human brain is often characterized in terms of a duality, with the left and right brains serving complementary functions, and even individuals are sometimes classified as either "left-brained" or "right-brained." Recent evidence from brain imaging shows that hemispheric asymmetry is multidimensional, comprised of ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/bs.pbr.2019.04.041
更新日期：2019-01-01 00:00:00
abstract：:Primates are able to recognize a particular object despite major differences in the retinal images of the object. Inferior temporal cortex is suggested to be involved in this invariant object recognition. Neurons of this cortex show shape selectivity and it has been shown that this shape selectivity is relatively inva...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)63330-0
更新日期：1996-01-01 00:00:00
abstract：:The receptor tyrosine kinase B, TrkB, is the high-affinity receptor for brain-derived neurotrophic factor (BDNF). Much evidence supports a role for TrkB signaling in excitatory synapse formation. There have been a number of recent advances in understanding the cell biology of TrkB-mediated excitatory synaptogenesis. T...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(06)57002-5
更新日期：2006-01-01 00:00:00
