Receptor tyrosine kinase B-mediated excitatory synaptogenesis.

Abstract:

:The receptor tyrosine kinase B, TrkB, is the high-affinity receptor for brain-derived neurotrophic factor (BDNF). Much evidence supports a role for TrkB signaling in excitatory synapse formation. There have been a number of recent advances in understanding the cell biology of TrkB-mediated excitatory synaptogenesis. The predominant mechanism by which TrkB supports excitatory synaptogenesis appears to be due to cell-autonomous signaling in both pre- and postsynaptic cells. This signaling appears to contribute to the growth and stabilization processes necessary for the net formation of synapses during development. Further, the molecular mechanisms by which TrkB contributes to these growth and stabilization processes are beginning to be elucidated.

journal_name

Prog Brain Res

authors

Luikart BW,Parada LF

doi

10.1016/s0079-6123(06)57002-5

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

15-24

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(06)57002-5

journal_volume

157

pub_type

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