NGF deprivation-induced gene expression: after ten years, where do we stand?

Abstract:

:Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over the last decade, a few additional genes (DP5, Bim, SM-20) have been added to a list that began with cyclin D1 and c-jun. In this chapter, we discuss the evidence that these genes act as regulators of neuronal cell death. We also suggest a hypothesis for how one gene, SM-20, may function to suppress a self-protection mechanism in NGF-deprived neurons.

journal_name

Prog Brain Res

authors

Freeman RS,Burch RL,Crowder RJ,Lomb DJ,Schoell MC,Straub JA,Xie L

doi

10.1016/S0079-6123(03)46008-1

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

111-26

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(03)46008-1

journal_volume

146

pub_type

历史文章,杂志文章,评审
  • Hilar mossy cells: functional identification and activity in vivo.

    abstract::Network oscillations are proposed to provide the framework for the ongoing neural computations of the brain. Thus, an important aspect of understanding the functional roles of various cell classes in the brain is to understand the relationship of cellular activity to the ongoing oscillations. While many studies have c...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)63012-X

    authors: Henze DA,Buzsáki G

    更新日期:2007-01-01 00:00:00

  • Role of calcium binding proteins in the control of cerebellar granule cell neuronal excitability: experimental and modeling studies.

    abstract::Calcium binding proteins, such as calretinin, are abundantly expressed in distinctive patterns in the central nervous system but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells which provide the major excitatory input to Purkinje cells through parallel fibers...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(04)48025-X

    authors: Gall D,Roussel C,Nieus T,Cheron G,Servais L,D'Angelo E,Schiffmann SN

    更新日期:2005-01-01 00:00:00

  • Current approaches and future directions to understanding control of head movement.

    abstract::This chapter reviews four key issues that must be addressed to advance our knowledge of control of head movement by the central nervous system (CNS). (1) Researchers must consider how the CNS utilizes the multiple muscle patterns that can produce the same head movement in carrying out tasks in an optimal way. (2) More...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(03)43035-5

    authors: Peterson BW

    更新日期:2004-01-01 00:00:00

  • Prostaglandin-induced neuropeptide release from spinal cord.

    abstract::The studies reviewed in this chapter present a convincing argument that prostaglandins have direct actions at the level of the spinal cord to enhance nociception. Furthermore, an increasing body of evidence supports the hypothesis that one important site of action of these eicosanoids is the terminals of sensory neuro...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)61801-4

    authors: Vasko MR

    更新日期:1995-01-01 00:00:00

  • Modeling the mammalian locomotor CPG: insights from mistakes and perturbations.

    abstract::A computational model of the mammalian spinal cord circuitry incorporating a two-level central pattern generator (CPG) with separate half-center rhythm generator (RG) and pattern formation (PF) networks is reviewed. The model consists of interacting populations of interneurons and motoneurons described in the Hodgkin-...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)65015-2

    authors: McCrea DA,Rybak IA

    更新日期:2007-01-01 00:00:00

  • Peptide receptors of the blood-brain barrier and substrate transport into the brain.

    abstract::The BBB is a target for some peptide signals, as demonstrated by our group for arginine-vasopressin (AVP) and atriopeptin (ANP). Peptide molecules contacting the luminal surface of endothelial cells interact with specific high-affinity binding sites. The minimal simple diffusion of peptide molecules across the layer o...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)62330-4

    authors: Ermisch A

    更新日期:1992-01-01 00:00:00

  • Molecular organization of cerebellar glutamate synapses.

    abstract::The organization of key molecules at glutamatergic synapses in the rat cerebellar cortex as analyzed by high resolution immunocytochemical techniques using gold particles as markers. The distinct compartmentation of glutamate and glutamine was consistent with biochemical data indicating an active role of glia in the r...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63360-9

    authors: Ottersen OP,Chaudhry FA,Danbolt NC,Laake JH,Nagelhus EA,Storm-Mathisen J,Torp R

    更新日期:1997-01-01 00:00:00

  • How the orbitofrontal cortex contributes to decision making - a view from neuroscience.

    abstract::In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review r...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)01306-5

    authors: Volz KG,von Cramon DY

    更新日期:2009-01-01 00:00:00

  • Consciousness and epilepsy: why are patients with absence seizures absent?

    abstract::Epileptic seizures cause dynamic, reversible changes in brain function and are often associated with loss of consciousness. Of all seizure types, absence seizures lead to the most selective deficits in consciousness, with relatively little motor or other manifestations. Impaired consciousness in absence seizures is no...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)50020-7

    authors: Blumenfeld H

    更新日期:2005-01-01 00:00:00

  • The role of executive function in the self-regulation of endurance performance: A critical review.

    abstract::Research has outlined how self-regulation is crucial to the decision-making processes and pacing of endurance performance. There is evidence to suggest that executive function is implicated in self-regulatory processes, as the two are conceptually similar and share common brain regions such as the prefrontal cortex. T...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2018.09.011

    authors: Hyland-Monks R,Cronin L,McNaughton L,Marchant D

    更新日期:2018-01-01 00:00:00

  • Artistic creativity and dementia.

    abstract::Artistic ability and creativity are defining characteristics of human behavior. Behavioral neurology, as a specialty, believes that even the most complex behaviors can be modeled and understood as the summation of smaller cognitive functions. Literature from individuals with specific brain lesions has helped to map ou...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-63287-6.00005-1

    authors: Miller ZA,Miller BL

    更新日期:2013-01-01 00:00:00

  • The psychosocial development of world-class athletes: Additional considerations for understanding the whole person and salience of adversity.

    abstract::In the target article, Hardy and colleagues provided an incisive analysis of retrospectively reported psychosocial factors associated with the development and careers of 32 former athletes from Olympic sports. They found that Super-Elite athletes ("serial" medal winners at major international championships, i.e., Worl...

    journal_title:Progress in brain research

    pub_type: 评论,杂志文章

    doi:10.1016/bs.pbr.2016.11.006

    authors: Gucciardi DF

    更新日期:2017-01-01 00:00:00

  • From attentional gating in macaque primary visual cortex to dyslexia in humans.

    abstract::Selective attention is an important aspect of brain function that we need in coping with the immense and constant barrage of sensory information. One model of attention (Feature Integration Theory) that suggests an early selection of spatial locations of objects via an attentional spotlight would also solve the 'bindi...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(01)34020-7

    authors: Vidyasagar TR

    更新日期:2001-01-01 00:00:00

  • Event-related potential studies of language and emotion: words, phrases, and task effects.

    abstract::This chapter reviews research that focuses on the effects of emotionality of single words, and of simple phrases, on event-related brain potentials when these are presented visually in various tasks. In these studies, presentation of emotionally evocative language material has consistently elicited a late (c. 300-600 ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)56009-1

    authors: Fischler I,Bradley M

    更新日期:2006-01-01 00:00:00

  • Neurological phenotypes for Down syndrome across the life span.

    abstract::This chapter reviews the neurological phenotype of Down syndrome (DS) in early development, childhood, and aging. Neuroanatomic abnormalities in DS are manifested as aberrations in gross brain structure as well as characteristic microdysgenetic changes. As the result of these morphological abnormalities, brain circuit...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-54299-1.00006-6

    authors: Lott IT

    更新日期:2012-01-01 00:00:00

  • Axonal and synaptic remodeling in the mature cerebellar cortex.

    abstract::By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to t...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(04)48005-4

    authors: Cesa R,Strata P

    更新日期:2005-01-01 00:00:00

  • Plasticity and regeneration in the injured spinal cord after cell transplantation therapy.

    abstract::Spinal cord injury (SCI) typically damages the long axonal tracts of the spinal cord which results in permanent disability. However, regeneration of the injured spinal cord is approaching reality according to the advances in stem cell biology. Cell transplantation therapy holds potential to lead to recovery following ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2016.12.007

    authors: Nori S,Nakamura M,Okano H

    更新日期:2017-01-01 00:00:00

  • General principles of rhythmogenesis in central pattern generator networks.

    abstract::The cellular and ionic mechanisms that generate the rhythm in central pattern generator (CPG) networks for simple movements are not well understood. Using vertebrate locomotion, respiration and mastication as exemplars, I describe four main principles of rhythmogenesis: (1) rhythmogenic ionic currents underlie all CPG...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/B978-0-444-53613-6.00014-9

    authors: Harris-Warrick RM

    更新日期:2010-01-01 00:00:00

  • Neuropharmacological effects of nicotine in relation to cholinergic mechanisms.

    abstract::Studies with nicotine have, from the outset, been of fundamental importance for the elucidation of physiological mechanisms. However, many nicotinic cholinoreceptors do not appear to subserve a physiological role, at least within the present framework of knowledge. The main challenge in the immediate future is to dete...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)62461-9

    authors: Rand MJ

    更新日期:1989-01-01 00:00:00

  • Exploring the nature and functions of the mind: a Tibetan Buddhist meditative perspective.

    abstract::The Tibetan Buddhist classification of mind, its divisions and the system of meditation practices aimed at achieving ideal states of being are a complex presentation of psychological, behavioral and spiritual concepts and processes that demand thorough understanding before assessing their value and outcome (Yeshe, 199...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)62160-3

    authors: Rapgay L,Rinpoche VL,Jessum R

    更新日期:2000-01-01 00:00:00

  • Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse.

    abstract::The serotonin (5-HT) neurotransmitter system provides fundamental modulatory regulation of the limbic-corticostriatal circuitry known to be vital in the development of addiction as well as the aspects of addiction that hinder recovery and contribute to relapse. Thus, components of the 5-HT system may provide novel tar...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)00916-3

    authors: Bubar MJ,Cunningham KA

    更新日期:2008-01-01 00:00:00

  • Control of urinary bladder function with devices: successes and failures.

    abstract::The management of urinary tract dysfunction is crucial for the health and well-being of people with spinal cord injury. Devices, specifically catheters, play an important role in the daily regime of bladder management for most people with spinal cord injury. However, the high incidence of complications associated with...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)52011-9

    authors: Gaunt RA,Prochazka A

    更新日期:2006-01-01 00:00:00

  • Deep brain stimulation in obsessive-compulsive disorder.

    abstract::The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently, deep brain stimulation in psychiatry is investigated for obsessive-compulsive ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(09)17527-1

    authors: Denys D,Mantione M

    更新日期:2009-01-01 00:00:00

  • Antidepressants for treatment of tinnitus.

    abstract::Antidepressants are commonly prescribed for tinnitus. Research thus far provides some support for that treatment, but the literature also raises concerns because tinnitus is a side effect of antidepressant medication. In this chapter, four published double blind placebo-controlled trials of antidepressants for tinnitu...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66024-5

    authors: Robinson S

    更新日期:2007-01-01 00:00:00

  • Transcranial magnetic stimulation (TMS) for treatment of chronic tinnitus: clinical effects.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method used to induce electrical current in the brain through impulses of strong magnetic fields applied externally. The technique can relieve tinnitus by modulating the excitability of neurons in the auditory cortex to decrease the hyperexcitabilit...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)66034-8

    authors: Kleinjung T,Steffens T,Londero A,Langguth B

    更新日期:2007-01-01 00:00:00

  • Fatigue with up- vs downregulated brain arousal should not be confused.

    abstract::Fatigue is considered to be an important and frequent factor in motivation problems. However, this term lacks clinical and pathophysiological validity. Semantic precision has to be improved. Lack of drive and tiredness with increased sleepiness as observed in fatigue in the context of inflammatory and immunological pr...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2016.06.001

    authors: Hegerl U,Ulke C

    更新日期:2016-01-01 00:00:00

  • Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways.

    abstract::Neuronal nitric oxide synthase (nNOS) participate in a variety of physiologic and pathologic processes in the nervous system. nNOS was originally felt to be a constitutively expressed enzyme, but recent observations suggest that its levels are dynamically controlled in response to neuronal development, plasticity and ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63196-9

    authors: Dawson TM,Sasaki M,Gonzalez-Zulueta M,Dawson VL

    更新日期:1998-01-01 00:00:00

  • Long descending motor tract axons and their control of neck and axial muscles.

    abstract::It has been tacitly assumed that a long descending motor tract axon consists of a private line connecting the cell of origin to a single muscle, as a motoneuron innervates a single muscle. However, this notion of a long descending motor tract referred to as a private line is no longer tenable, since recent studies hav...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(05)51017-3

    authors: Shinoda Y,Sugiuchi Y,Izawa Y,Hata Y

    更新日期:2006-01-01 00:00:00

  • Spoken language and the decision to move the eyes: to what extent are language-mediated eye movements automatic?

    abstract::Recent eye-tracking research has revealed that spoken language can guide eye gaze very rapidly (and closely time-locked to the unfolding speech) toward referents in the visual world. We discuss whether, and to what extent, such language-mediated eye movements are automatic rather than subject to conscious and controll...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-62604-2.00008-3

    authors: Mishra RK,Olivers CN,Huettig F

    更新日期:2013-01-01 00:00:00

  • Stimulus-driven changes in sensorimotor behavior and neuronal functional connectivity application to brain-machine interfaces and neurorehabilitation.

    abstract::Normal brain function requires constant adaptation as an organism interacts with the environment and learns to associate important sensory stimuli with appropriate motor actions. Neurological disorders may disrupt these learned associations, potentially requiring new functional pathways to be formed to replace the los...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-53355-5.00006-3

    authors: Rebesco JM,Miller LE

    更新日期:2011-01-01 00:00:00