Fatigue with up- vs downregulated brain arousal should not be confused.

Abstract:

:Fatigue is considered to be an important and frequent factor in motivation problems. However, this term lacks clinical and pathophysiological validity. Semantic precision has to be improved. Lack of drive and tiredness with increased sleepiness as observed in fatigue in the context of inflammatory and immunological processes (hypoaroused fatigue) has to be separated from inhibition of drive and tiredness with prolonged sleep onset latency as observed in major depression (hyperaroused fatigue). Subjective experiences as reported by patients, as well as clinical, behavioral, and neurobiological findings support the validity and importance of this distinction. A practical clinical procedure for how to separate hypo- from hyperaroused fatigue will be proposed.

journal_name

Prog Brain Res

authors

Hegerl U,Ulke C

doi

10.1016/bs.pbr.2016.06.001

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

239-254

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(16)30061-9

journal_volume

229

pub_type

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