Involvement of astrocytes in neurovascular communication.

Abstract:

:The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional roles of astrocytes including astrocytic modulation of the vasculature. Additionally, astrocytes develop an intricate morphology that intimately apposes neuronal synapses, making them an ideal cellular mediator of neurovascular coupling. In this article, we first introduce the classical anatomical and physiological findings that led to the proposal of various gliovascular interaction models. Next, we touch on the technological advances in the past few decades that enabled investigations and evaluations of neuro-glio-vascular interactions in situ. We then review recent experimental findings on the roles of astrocytes in neurovascular coupling from the viewpoints of intra- and intercellular signalings in astrocytes.

journal_name

Prog Brain Res

authors

Nuriya M,Hirase H

doi

10.1016/bs.pbr.2016.02.001

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

41-62

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(16)00036-4

journal_volume

225

pub_type

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