Abstract：
:By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to the parallel fiber synapses, appears in the spines contacted by the climbing fibers before they disconnect from the target. A similar pattern of hyperspiny transformation and innervation occurs a few days after a subtotal lesion of the inferior olive, the source of climbing fibers. During the climbing fiber reinnervation process which follows the removal of the electrical block or by collateral sprouting of surviving inferior olive neurons, the new active climbing fibers establish synaptic contacts with proximal dendritic spines that bear GluRdelta2s. After, they repress these subunits and displace the parallel fibers to the distal dendritic territory. These findings suggest the following operational principle in the axonal competition for a common target. The Purkinje cells have an intrinsic phenotypic profile which is compatible with the parallel fiber innervation, this mode being operational in targets innervated by a single neuronal population, like the neuromuscular system. An additional input, the climbing fibers, in order to achieve its own territory on the proximal dendrite needs the ability to displace the competitor. Such an inhibition is activity-dependent and the activity needs to be present in order to allow the climbing fiber to maintain its territory, even when the developmental period is over.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Cesa R,Strata Pdoi
10.1016/S0079-6123(04)48005-4subject
Has Abstractpub_date
2005-01-01 00:00:00pages
45-56eissn
0079-6123issn
1875-7855pii
S0079612304480054journal_volume
148pub_type
杂志文章,评审abstract：:Predictive processes are widespread in the motor and sensory areas of the primate brain. They enable rapid computations despite processing delays and assist in resolving noisy, ambiguous input. Here we propose that the frontal eye field, a cortical area devoted to sensorimotor aspects of eye movement control, implemen...
journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/S0079-6123(08)00656-0
更新日期：2008-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(02)39021-6
更新日期：2002-01-01 00:00:00
abstract：:Variation in neocortex size is one of the defining features of mammalian brain evolution. The paramount assumption has been that neocortex size indicates a monotonic allometric relationship with brain size. This assumption holds the concomitant neurodevelopmental assumption that the ontogenetic trajectory of neocortex...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)63828-5
更新日期：1991-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)62294-3
更新日期：1993-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/B978-0-444-53860-4.00021-0
更新日期：2012-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：1994-01-01 00:00:00
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doi：10.1016/S0079-6123(10)82012-6
更新日期：2010-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/bs.pbr.2017.05.004
更新日期：2017-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(06)57020-7
更新日期：2006-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/B978-0-444-53884-0.00015-4
更新日期：2011-01-01 00:00:00
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journal_title：Progress in brain research
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更新日期：2011-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(05)50020-7
更新日期：2005-01-01 00:00:00
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journal_title：Progress in brain research
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更新日期：2015-01-01 00:00:00
abstract：:Spinal cord evoked potentials (SCEP) are good indicators of spinal cord function in health and disease. Disturbances in SCEP amplitudes and latencies during spinal cord monitoring predict spinal cord pathology following trauma. Treatment with neuroprotective agents preserves SCEP and reduces cord pathology after injur...
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doi：10.1016/bs.pbr.2020.09.012
更新日期：2020-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 历史文章,杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Progress in brain research
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更新日期：2009-01-01 00:00:00
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journal_title：Progress in brain research
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更新日期：2012-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(06)61025-X
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journal_title：Progress in brain research
pub_type： 杂志文章
doi：10.1016/s0079-6123(08)63340-3
更新日期：1996-01-01 00:00:00
abstract：:Nitric oxide (NO) is widespread in the nervous system and is thought to play a role in a variety of different neuronal functions, including learning and memory (see other chapters, this volume). A number of behavioral studies have indicated that NO is involved in several types of learning such as motor learning (Yanag...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
abstract：:The ability to form tenable hypotheses regarding the neurobiological basis of normative functions as well as mechanisms underlying neurodegenerative and neuropsychiatric disorders is often limited by the highly complex brain circuitry and the cellular and molecular mosaics therein. The brain is an intricate structure ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Progress in brain research
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
abstract：:The BBB is a target for some peptide signals, as demonstrated by our group for arginine-vasopressin (AVP) and atriopeptin (ANP). Peptide molecules contacting the luminal surface of endothelial cells interact with specific high-affinity binding sites. The minimal simple diffusion of peptide molecules across the layer o...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/s0079-6123(08)62330-4
更新日期：1992-01-01 00:00:00
abstract：:Objects have specific cognitive attributes, elicit particular visuo-motor responses, and require visual processes beyond primary visual cortex to combine information over extended regions as a basis for the segmentation and integration of visual objects. As well as segmentation, the assignment of region boundaries to ...
journal_title：Progress in brain research
pub_type： 杂志文章,评审
doi：10.1016/S0079-6123(07)64008-4
更新日期：2007-01-01 00:00:00
