Deep brain stimulation in obsessive-compulsive disorder.

Abstract:

:The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently, deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, Gilles de la Tourette's syndrome, and major depression. This chapter reviews the application of deep brain stimulation in obsessive-compulsive disorder. Preliminary results suggest that deep brain stimulation in obsessive-compulsive disorder can effectuate a decrease of 40-60% in at least half of the patients. Although various side effects occur, most of these are transitory and linked to specific stimulation parameters which can be changed. Because only a few studies have been performed with a limited number of patients in accordance with varying research protocols, appliance of deep brain stimulation to obsessive-compulsive disorder is still at an experimental stage. The speed of the effect of deep brain stimulation causes fundamental assumptions on the pathophysiology of obsessive-compulsive disorder.

journal_name

Prog Brain Res

authors

Denys D,Mantione M

doi

10.1016/S0079-6123(09)17527-1

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

419-27

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(09)17527-1

journal_volume

175

pub_type

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