Abstract:
:Sub-lethal exposure to practically any harmful stimulus has been shown to induce consequent protection against more severe stress. This preconditioning (PC) effect may be achieved by exposure to different stressors, indicating that the induction of tolerance involves activation of common protective pathways. Chronic exposure to moderate heat (heat acclimation, HA) is a unique PC model, since this global physiological adaptation, as opposed to discrete organ PC, has been shown to induce cross-tolerance against other stressors, including closed head injury (CHI). HA animals show accelerated functional recovery after injury which is accompanied by reduced secondary brain damage. However, the precise mechanisms underlying this phenomenon have not been thoroughly studied until recently. Here we will address the concept of PC, highlighting the unique properties of HA as a model which can be used for the study of endogenous protective pathways triggered by PC procedures. Several molecular mechanisms which are suggested to mediate HA-induced neuroprotection will also be discussed, bringing to light their potential contribution to the development of traumatic brain injury treatment strategies utilizing therapeutic augmentation of endogenous defense mechanisms.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Shein NA,Horowitz M,Shohami Edoi
10.1016/S0079-6123(06)61025-Xsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
353-63eissn
0079-6123issn
1875-7855pii
S0079-6123(06)61025-Xjournal_volume
161pub_type
杂志文章,评审abstract::This contribution reviewed the available evidence on the domain-specific and domain-general neurocognitive determinants of children's arithmetic development, other than nonsymbolic numerical magnitude processing, which might have been overemphasized as a core factor of individual differences in mathematics and dyscalc...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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abstract::This chapter describes current findings from the research into postoperative cognitive dysfunction (POCD) following cardiac and non-cardiac surgery in older adults. The evidence suggests that a significant proportion of patients show POCD in the early weeks following surgery and anesthesia. Specific domains of cogniti...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61801-4
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abstract::This chapter reviews research that focuses on the effects of emotionality of single words, and of simple phrases, on event-related brain potentials when these are presented visually in various tasks. In these studies, presentation of emotionally evocative language material has consistently elicited a late (c. 300-600 ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)56009-1
更新日期:2006-01-01 00:00:00
abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
abstract::The nervous system can generate rhythms of various frequencies; on the low-frequency side, we have the circuits regulating circadian rhythms with a 24-h period, while on the high-frequency side we have the motor circuits that underlie flight in a hummingbird. Given the ubiquitous nature of rhythms, it is surprising th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53613-6.00004-6
更新日期:2010-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)61005-4
更新日期:2007-01-01 00:00:00
abstract::The data presented in this paper show that the appropriate tools are now available to study the behavior of PLP and DM20 transcripts engineered with either point mutations or deletion of specific domains. Such studies should begin to provide new insights into the functions of PLP and DM20 and their role in relation to...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63307-5
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)01124-2
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53702-7.00001-4
更新日期:2010-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(09)17613-6
更新日期:2009-01-01 00:00:00
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journal_title:Progress in brain research
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更新日期:2009-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)01114-X
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2017.07.010
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journal_title:Progress in brain research
pub_type: 传,历史文章,杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61255-8
更新日期:1990-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)61015-7
更新日期:2007-01-01 00:00:00
abstract::Using alternatively labelled (-)-deprenyl (3H label in the ring and 14C in the propargyl group) the distribution of the compound was studied in 15 brain regions and the plasma of rats over a period of 96 h, after oral administration of 1.5 mg/kg of (-)-deprenyl. The compound is rapidly absorbed (within 15-30 min) from...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)61211-x
更新日期:1995-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-62604-2.00008-3
更新日期:2013-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)59001-6
更新日期:2006-01-01 00:00:00
abstract::The role of the superior colliculus in attending and orienting to sensory stimuli is facilitated by the presence within this midbrain nucleus of superimposed maps of different sensory modalities. We have studied the steps involved in the development of topographically-aligned maps of visual and auditory space in the f...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63340-3
更新日期:1996-01-01 00:00:00
abstract::Studies with nicotine have, from the outset, been of fundamental importance for the elucidation of physiological mechanisms. However, many nicotinic cholinoreceptors do not appear to subserve a physiological role, at least within the present framework of knowledge. The main challenge in the immediate future is to dete...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62461-9
更新日期:1989-01-01 00:00:00
abstract::It was generally accepted by the early 1960s that proton beam radiosurgery was too complex and impractical. The need was seen for a new machine. The beam design had to be as good as a proton beam. It was also decided that a static design was preferable even if the evolution of that notion is no longer clear. Complex c...
journal_title:Progress in brain research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/B978-0-444-63520-4.00007-7
更新日期:2014-01-01 00:00:00