Heat acclimation: a unique model of physiologically mediated global preconditioning against traumatic brain injury.

Abstract:

:Sub-lethal exposure to practically any harmful stimulus has been shown to induce consequent protection against more severe stress. This preconditioning (PC) effect may be achieved by exposure to different stressors, indicating that the induction of tolerance involves activation of common protective pathways. Chronic exposure to moderate heat (heat acclimation, HA) is a unique PC model, since this global physiological adaptation, as opposed to discrete organ PC, has been shown to induce cross-tolerance against other stressors, including closed head injury (CHI). HA animals show accelerated functional recovery after injury which is accompanied by reduced secondary brain damage. However, the precise mechanisms underlying this phenomenon have not been thoroughly studied until recently. Here we will address the concept of PC, highlighting the unique properties of HA as a model which can be used for the study of endogenous protective pathways triggered by PC procedures. Several molecular mechanisms which are suggested to mediate HA-induced neuroprotection will also be discussed, bringing to light their potential contribution to the development of traumatic brain injury treatment strategies utilizing therapeutic augmentation of endogenous defense mechanisms.

journal_name

Prog Brain Res

authors

Shein NA,Horowitz M,Shohami E

doi

10.1016/S0079-6123(06)61025-X

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

353-63

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(06)61025-X

journal_volume

161

pub_type

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