Development of motor rhythms in zebrafish embryos.

Abstract:

:The nervous system can generate rhythms of various frequencies; on the low-frequency side, we have the circuits regulating circadian rhythms with a 24-h period, while on the high-frequency side we have the motor circuits that underlie flight in a hummingbird. Given the ubiquitous nature of rhythms, it is surprising that we know very little of the cellular and molecular mechanisms that produce them in the embryos and of their potential role during the development of neuronal circuits. Recently, zebrafish has been developed as a vertebrate model to study the genetics of neural development. Zebrafish offer several advantages to the study of nervous system development including optical and electrophysiological analysis of neuronal activity even at the earliest embryonic stages. This unique combination of physiology and genetics in the same animal model has led to insights into the development of neuronal networks. This chapter reviews work on the development of zebrafish motor rhythms and speculates on birth and maturation of the circuits that produce them.

journal_name

Prog Brain Res

authors

Saint-Amant L

doi

10.1016/B978-0-444-53613-6.00004-6

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

47-61

eissn

0079-6123

issn

1875-7855

pii

B978-0-444-53613-6.00004-6

journal_volume

187

pub_type

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