Abstract:
:Normal-tension glaucoma (NTG) is generally defined as visual field loss and optic nerve defects consistent with glaucoma and an intraocular pressure (IOP) that does not exceed 21 mmHg (Allingham, R.R., Damji, K., Freedman, S., Moroi, S., Shafranov, G., Shields, M.B. (2005). In: Pine J. and Murphy J. (Eds.), Shields' Textbook of Glaucoma, 5th edn., Lippincott Williams & Wilkins, Philadelphia, PA, pp. 197-207, Chapter 11). If a patient has an atypical presentation (unilateral disease, decreased central visual acuity or visual field loss not consistent with optic disk appearance) then the clinician should rule out medical or neurologic etiologies. IOP-dependent and IOP-independent mechanisms play a role in NTG nerve damage. The exact mechanisms of IOP-independent damage are not currently known. Research has shown that vascular etiologies, such as vascular insufficiency and vasospasm, may be possible mechanisms for IOP-independent damage. The mainstay of glaucoma treatment remains robust IOP reduction. The chief goal of ongoing glaucoma research is to more clearly identify IOP-independent mechanisms of damage and to find neuroprotective treatment strategies to prevent retinal ganglion cell death and consequent visual loss.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Desai PV,Caprioli Jdoi
10.1016/S0079-6123(08)01114-Xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
195-210eissn
0079-6123issn
1875-7855pii
S0079-6123(08)01114-Xjournal_volume
173pub_type
杂志文章abstract::The effects of endogenous metabolites of the neuropeptide vasopressin (VP) in behavioural tests led to the hypothesis that VP metabolites have a more selective function than VP. In contrast to VP, no peripheral effects have been found thus far with VP metabolites and their function seems to be associated with memory-r...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61591-5
更新日期:1998-01-01 00:00:00
abstract::In vivo functional imaging has provided objective evidence for the integration and function of nigral grafts in the brains of patients with Parkinson's disease. Clinical trials with the use of positron emission tomography have shown that transplants of human dopamine-rich fetal ventral mesencephalic tissue can survive...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-59575-1.00009-0
更新日期:2012-01-01 00:00:00
abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63798-x
更新日期:1991-01-01 00:00:00
abstract::The complex migrations of neurons born in the dorsal neural tube of the isthmic and rhombomere l (rl) domains complicate the delineation of the cerebellar primordium. We show that Purkinje cells (P) are likely generated over a wide territory before gathering in the future cerebellar primordium under the developing ext...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(04)48003-0
更新日期:2005-01-01 00:00:00
abstract::It has been known for decades that females are more susceptible than men to inflammatory autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis, and psoriasis. In addition, female patients with these diseases experience clinical improvements during pregnancy with a temporary "rebound" exacerbatio...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17516-7
更新日期:2009-01-01 00:00:00
abstract::It is a clinical reality that women make up the large majority of chronic pain patients, and there is now consensus from laboratory experiments that when differences are seen, women are more sensitive to pain than men. Research in this field has now begun to concentrate on finding explanations for this sex difference....
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53630-3.00009-9
更新日期:2010-01-01 00:00:00
abstract::Nitric oxide (NO) is widespread in the nervous system and is thought to play a role in a variety of different neuronal functions, including learning and memory (see other chapters, this volume). A number of behavioral studies have indicated that NO is involved in several types of learning such as motor learning (Yanag...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63206-9
更新日期:1998-01-01 00:00:00
abstract::Gamma aminobutyric acid (GABA) is an inhibitor neurotransmitter that plays many important roles in the central nervous system. Because the half-life time of GABA is very short in vivo, GABA itself is not used for clinical practice. An analogue of GABA, baclofen, is an agonist of GABA-B receptor, and has very strong an...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(09)17721-X
更新日期:2009-01-01 00:00:00
abstract::John Bell, brother-surgeon of Charles Bell, was, like Charles, an outstanding surgeon and a good artist. John was one of the few who illustrated his work with their own drawings in the days before audiovisual aids were available and without the benefit of reliable drawing aids, photography and computer-aided design. C...
journal_title:Progress in brain research
pub_type: 传,历史文章,杂志文章
doi:10.1016/B978-0-444-62730-8.00006-2
更新日期:2013-01-01 00:00:00
abstract::Paired organotypic explants from rat occipital cortex were cultured for up to three weeks in the presence of selective blockers of amino acid receptor blockers, during which period spontaneous action potential generation was monitored electrophysiologically. In contrast to isolated explants (Corner, M.A., van Pelt, J....
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)47018-6
更新日期:2005-01-01 00:00:00
abstract::N-methyl-D-aspartate (NMDA) receptors have been implicated as a mediator of neuronal injury associated with many neurological disorders including ischemia, epilepsy, brain trauma, dementia and neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease. To this, non-selective NMDA receptor ant...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(10)83009-2
更新日期:2010-01-01 00:00:00
abstract::We present results of a study of torsional eye movements evoked by earth-vertical accelerations along the subject's longitudinal axis. The earth-vertical stimulus leads to a gravito-inertial acceleration vector that changes magnitude but not direction. It can therefore be viewed as a dynamic change of the gravity leve...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00646-8
更新日期:2008-01-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) participate in a variety of physiologic and pathologic processes in the nervous system. nNOS was originally felt to be a constitutively expressed enzyme, but recent observations suggest that its levels are dynamically controlled in response to neuronal development, plasticity and ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63196-9
更新日期:1998-01-01 00:00:00
abstract::The organization of key molecules at glutamatergic synapses in the rat cerebellar cortex as analyzed by high resolution immunocytochemical techniques using gold particles as markers. The distinct compartmentation of glutamate and glutamine was consistent with biochemical data indicating an active role of glia in the r...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63360-9
更新日期:1997-01-01 00:00:00
abstract::PTSD arises by definition as a direct consequence of the experience of an acute severe stressor. The formation of traumatic memory and its extinction, sympathetic and adrenocortical stress systems activity in relation to individual vulnerability form the core of animal models for PTSD. ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)67008-3
更新日期:2008-01-01 00:00:00
abstract::Aromatase is the enzyme that catalyzes the last step of estrogen biosynthesis. It is expressed in many tissues such as the gonads, brain and adipose tissue. The regulation of the level and activity of aromatase determines the levels of estrogens that have endocrine, paracrine and autocrine effects on tissues. Estrogen...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)81012-6
更新日期:2010-01-01 00:00:00
abstract::Compensatory electromyographic (EMG) responses and several biomechanical parameters were studied following impulsive disturbance of the limbs during stance of human volunteers on a treadmill. Treadmill acceleration impulses were backwards or forwards directed, or their initial direction was reversed after 30 ms. Backw...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62238-4
更新日期:1989-01-01 00:00:00
abstract::In order to study cerebral activity related to preparation and execution of movement, evoked and induced brain electrical activities were compared to each other and to fMRI results in voluntary self-paced movements. Also, the event-related desynchronization and synchronization (ERD/ERS) were studied in complex movemen...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(06)59021-1
更新日期:2006-01-01 00:00:00
abstract::Metabolic status varies predictably on a daily and seasonal basis in order to adapt to the cyclical environment. The hypothalamic circadian pacemaker of the suprachiasmatic nuclei (SCN) co-ordinates these metabolic cycles. Circadian timing is based upon a transcriptional/post-translational negative feedback loop invol...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)53015-8
更新日期:2006-01-01 00:00:00
abstract::A dense serotonin (5-HT)-containing projection to the superficial layers of the superior colliculus (SC) has been demonstrated in diverse mammalian species, but how 5-HT may affect visual signals within these laminae is largely unknown. This study undertook to investigate the distribution of 2 types of 5-HT receptors ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63320-8
更新日期:1996-01-01 00:00:00
abstract::Cognitive control and decision making are two important research areas in the realm of higher-order cognition. Control processes such as interference control and monitoring in cognitive and affective contexts have been found to influence the process of decision making. Development of control processes follows a gradua...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/B978-0-444-62604-2.00018-6
更新日期:2013-01-01 00:00:00
abstract::The capacity to sustain high-intensity aerobic exercise is essential for endurance performance. Therefore, it is important to understand what is the factor limiting time to exhaustion (TTE) in healthy and fit adults. In Study 1, maximal voluntary cycling power (MVCP) was measured in 11 volunteers before and immediatel...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2018.09.012
更新日期:2018-01-01 00:00:00
abstract::Normal brain function requires constant adaptation as an organism interacts with the environment and learns to associate important sensory stimuli with appropriate motor actions. Neurological disorders may disrupt these learned associations, potentially requiring new functional pathways to be formed to replace the los...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53355-5.00006-3
更新日期:2011-01-01 00:00:00
abstract::Selective attention is an important aspect of brain function that we need in coping with the immense and constant barrage of sensory information. One model of attention (Feature Integration Theory) that suggests an early selection of spatial locations of objects via an attentional spotlight would also solve the 'bindi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)34020-7
更新日期:2001-01-01 00:00:00
abstract::The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)00006-4
更新日期:2008-01-01 00:00:00
abstract::Traumatic brain injury (TBI) research to date has focused almost exclusively on the pathophysiology of injured neurons with very little attention paid to non-neuronal cells. However in the past decade, exciting discoveries have challenged this century-old view of passive glial cells and have led to a reinterpretation ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)61005-4
更新日期:2007-01-01 00:00:00
abstract::The dorsal striatum (caudate putamen) contains two types of GABAergic medium spiny neurons (MSNs) that are distinguished by the expression of either the opioid peptide, enkephalin, or the opioid peptide, dynorphin, as well as the tachykinin substance P. Pharmacological studies suggest that these peptides modulate loca...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)60016-2
更新日期:2007-01-01 00:00:00
abstract::Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits c...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(10)84014-2
更新日期:2010-01-01 00:00:00
abstract::Recent upsurge in research has uncovered distinct circuitries that regulate appetite, energy expenditure and fat accrual under the supervision of hormonal feedback signalling of adipocyte leptin and gastric ghrelin in the hypothalamic integration of energy homeostasis. A host of messenger molecules of diverse chemical...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)81002-3
更新日期:2010-01-01 00:00:00
abstract::Swallowing is an essential function in our daily life; nevertheless, stroke or other neurodegenerative diseases can cause the malfunction of swallowing function, ie, dysphagia. The objectives of this review are to understand the neural and cortical basis of swallowing and tongue, and review the latest techniques on th...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2016.03.014
更新日期:2016-01-01 00:00:00