Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase.

Abstract:

:The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.

journal_name

Prog Brain Res

authors

Abel T,Nguyen PV

doi

10.1016/S0079-6123(07)00006-4

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

97-115

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(07)00006-4

journal_volume

169

pub_type

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