Abstract:
:The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Abel T,Nguyen PVdoi
10.1016/S0079-6123(07)00006-4subject
Has Abstractpub_date
2008-01-01 00:00:00pages
97-115eissn
0079-6123issn
1875-7855pii
S0079-6123(07)00006-4journal_volume
169pub_type
杂志文章,评审abstract::The capacity to sustain high-intensity aerobic exercise is essential for endurance performance. Therefore, it is important to understand what is the factor limiting time to exhaustion (TTE) in healthy and fit adults. In Study 1, maximal voluntary cycling power (MVCP) was measured in 11 volunteers before and immediatel...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2018.09.012
更新日期:2018-01-01 00:00:00
abstract::In order to study cerebral activity related to preparation and execution of movement, evoked and induced brain electrical activities were compared to each other and to fMRI results in voluntary self-paced movements. Also, the event-related desynchronization and synchronization (ERD/ERS) were studied in complex movemen...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(06)59021-1
更新日期:2006-01-01 00:00:00
abstract::For diagnostic purposes, a differentiation can be made between the locus coeruleus (LC) in normal brain and the LC, in senile dementia of the Alzheimer's type (SDAT) and Parkinson's disease (PD). The differentiation is based on findings concerning the morphological alterations of the TH-immunoreactive; neurons, on the...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63839-x
更新日期:1991-01-01 00:00:00
abstract::Disrupted in Schizophrenia-1 (DISC1) is one of the most likely susceptibility genes for schizophrenia (SZ). DISC1 is being established as a hub protein with various functions in the pre- and postnatal development of the nervous system. Since generation of a knockout (KO) mouse has proved challenging, various alternati...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17909-8
更新日期:2009-01-01 00:00:00
abstract::The major point of this chapter is that there is evidence to support the idea that cervical headache might not only result from injured somatic structures in the neck but also occur because of interactions with visceral organs. The complex arrangement of convergent inputs from somatic and visceral afferent fibers and ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62140-8
更新日期:2000-01-01 00:00:00
abstract::The storage and elimination of urine requires the coordination of activity between the autonomic nervous system (thoracolumbar sympathetic and sacral parasympathetic divisions) controlling the urinary bladder and urethra and the lumbosacral somatic motoneurons innervating the striated sphincter and pelvic floor muscle...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(02)37008-0
更新日期:2002-01-01 00:00:00
abstract::This chapter provides evidence of spatial and temporal changes in the behavior of neurons within Areas 5 and 4 of the sensorimotor cortex of a nonhuman primate while it was executing a perturbed arm-reaching task. Chronically implanted electrode arrays were used to record simultaneously from 37 to 58 neurons. Also mea...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(03)43045-8
更新日期:2004-01-01 00:00:00
abstract::Recent accounts of tinnitus development and maintenance assign an important role to central mechanisms. Residual inhibition is a frequent phenomenon in individuals with tinnitus, and refers to the fact that tinnitus can temporarily be reduced by presenting sounds or noises that inhibit tinnitus for a limited time even...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)66044-0
更新日期:2007-01-01 00:00:00
abstract::Molecular biology techniques have begun to shed light on the genetic basis of autosomal dominant central DI, but several very basic questions remain to be answered. The disorder was initially presumed to have a developmental, degenerative, or autoimmune basis based on the autopsy findings in the hypothalamus of a limi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)64580-x
更新日期:1992-01-01 00:00:00
abstract::Cognitive neuroscience is currently finding itself as a marketing trend in occupational science, particularly in terms of workplace assessment and measurement. However, the field has historically had little to do with occupational applications and has generally remained focused on the clinical and academic relevance o...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2020.05.032
更新日期:2020-01-01 00:00:00
abstract::The interactions of the dendritically released neuropeptides vasopressin and oxytocin with co-released neuroactive substances such as opioids and nitric oxide are reviewed. Endogenous opioids regulate magnocellular neurons at the level of the supraoptic nucleus and the relationship of dendritically released peptides a...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(02)39021-6
更新日期:2002-01-01 00:00:00
abstract::The human brain is often characterized in terms of a duality, with the left and right brains serving complementary functions, and even individuals are sometimes classified as either "left-brained" or "right-brained." Recent evidence from brain imaging shows that hemispheric asymmetry is multidimensional, comprised of ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2019.04.041
更新日期:2019-01-01 00:00:00
abstract::There is increasing evidence that human cognitive functions can be addressed from a robust neuroscience perspective. In particular, the distributed coherent electrical properties of central neuronal ensembles are considered to be a promising avenue of inquiry concerning global brain functions. The intrinsic oscillator...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)50010-4
更新日期:2005-01-01 00:00:00
abstract::Recent eye-tracking research has revealed that spoken language can guide eye gaze very rapidly (and closely time-locked to the unfolding speech) toward referents in the visual world. We discuss whether, and to what extent, such language-mediated eye movements are automatic rather than subject to conscious and controll...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-62604-2.00008-3
更新日期:2013-01-01 00:00:00
abstract::Research points to the notion that athletes have the potential to benefit from difficulty. This phenomenon-otherwise known as growth following adversity-has attracted increasing attention from sport psychology scholars. In this paper, we systematically review and synthesize the findings of studies in this area to bett...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2017.06.002
更新日期:2017-01-01 00:00:00
abstract::In this chapter, the distribution of Hsp70 in brain cell types following whole body hyperthermia is reviewed. The prevalence of Hsp70 expression in oligodendrocytes, microglia, and vascular cells in this type of stress contrasts with scarcity of Hsp70 induction in astrocytes and most neurons of the hyperthermic brain....
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)62020-7
更新日期:2007-01-01 00:00:00
abstract::In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review r...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(09)01306-5
更新日期:2009-01-01 00:00:00
abstract::A problem for studies of all cortex, including prefrontal cortex, is how to relate results to proposed subdivisions of the brain and how to compare results across species. Investigators have been highly dependent on traditional architectonic maps of neocortex. However, over the last 20 years, other methods, especially...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62673-4
更新日期:1990-01-01 00:00:00
abstract::Objects have specific cognitive attributes, elicit particular visuo-motor responses, and require visual processes beyond primary visual cortex to combine information over extended regions as a basis for the segmentation and integration of visual objects. As well as segmentation, the assignment of region boundaries to ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)64008-4
更新日期:2007-01-01 00:00:00
abstract::Spinal cord evoked potentials (SCEP) are good indicators of spinal cord function in health and disease. Disturbances in SCEP amplitudes and latencies during spinal cord monitoring predict spinal cord pathology following trauma. Treatment with neuroprotective agents preserves SCEP and reduces cord pathology after injur...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2020.09.012
更新日期:2020-01-01 00:00:00
abstract::It was generally accepted by the early 1960s that proton beam radiosurgery was too complex and impractical. The need was seen for a new machine. The beam design had to be as good as a proton beam. It was also decided that a static design was preferable even if the evolution of that notion is no longer clear. Complex c...
journal_title:Progress in brain research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/B978-0-444-63520-4.00007-7
更新日期:2014-01-01 00:00:00
abstract::The studies reviewed in this chapter present a convincing argument that prostaglandins have direct actions at the level of the spinal cord to enhance nociception. Furthermore, an increasing body of evidence supports the hypothesis that one important site of action of these eicosanoids is the terminals of sensory neuro...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61801-4
更新日期:1995-01-01 00:00:00
abstract::In the last few years, theorists have argued that culture can shape processes of basic visual perception. This work has primarily focused on cultural influences in nonsocial domains, such as cross-cultural differences in seeing and attending to focal stimuli versus backgrounds. Recently, researchers have begun to exam...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(09)17813-5
更新日期:2009-01-01 00:00:00
abstract::The receptor tyrosine kinase B, TrkB, is the high-affinity receptor for brain-derived neurotrophic factor (BDNF). Much evidence supports a role for TrkB signaling in excitatory synapse formation. There have been a number of recent advances in understanding the cell biology of TrkB-mediated excitatory synaptogenesis. T...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(06)57002-5
更新日期:2006-01-01 00:00:00
abstract::Findings on nonprimate mammals place the issue of mother-infant lateralized relations in a broader context, demonstrating that humans are one of many species showing this feature. The remarkable interspecies consistency in the direction of lateralization points to a continuity between lateralized mother-infant interac...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2018.06.003
更新日期:2018-01-01 00:00:00
abstract::Hand preference is a sensorimotor skill whose development both reflects and promotes the development of hemispheric lateralization for manual and cognitive functions. Extensive comparative, crosscultural, and paleoanthropological evidence demonstrates the prevalence of limb lateralized preferences across vertebrate sp...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2018.06.007
更新日期:2018-01-01 00:00:00
abstract::An unresolved issue in visual motion perception is how distinct are the processes underlying 'first-order' and 'second-order' motion. The former is defined by spatio-temporal variations of luminance and the latter by spatio-temporal variations in other image attributes such as contrast or depth, for example. Using neu...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)14414-7
更新日期:2004-01-01 00:00:00
abstract::Experimental investigations of the lumbar sympathetic outflow to skin, skeletal muscle and viscera and the thoracic sympathetic outflow to the head and neck have shown that each target organ and tissue is supplied by one or two separate pathways which consists of sets of pre- and postganglionic neurons with distinct p...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)62150-0
更新日期:2000-01-01 00:00:00
abstract::Retinogeniculate connections are one of the most striking examples of connection specificity within the visual pathway. In almost every connection there is one dominant afferent cell per geniculate cell, and both afferent and geniculate cells have very similar receptive fields. The remarkable specificity and strength ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)54001-4
更新日期:2006-01-01 00:00:00
abstract::Normal brain function requires constant adaptation as an organism interacts with the environment and learns to associate important sensory stimuli with appropriate motor actions. Neurological disorders may disrupt these learned associations, potentially requiring new functional pathways to be formed to replace the los...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53355-5.00006-3
更新日期:2011-01-01 00:00:00