Estrogen and testosterone therapies in multiple sclerosis.

Abstract:

:It has been known for decades that females are more susceptible than men to inflammatory autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis, and psoriasis. In addition, female patients with these diseases experience clinical improvements during pregnancy with a temporary "rebound" exacerbation postpartum. These clinical observations indicate an effect of sex hormones on disease and suggest the potential use of the male hormone testosterone and the pregnancy hormone estriol, respectively, for the treatment of MS. A growing number of studies using the MS animal model experimental autoimmune encephalomyelitis (EAE) support a therapeutic effect of these hormones. Both testosterone and estriol have been found to induce anti-inflammatory as well as neuroprotective effects. Findings from two recent pilot studies of transdermal testosterone in male MS patients and oral estriol in female MS patients are encouraging. In this paper, we review the preclinical and clinical evidence for sex hormone treatments in MS and discuss potential mechanisms of action.

journal_name

Prog Brain Res

authors

Gold SM,Voskuhl RR

doi

10.1016/S0079-6123(09)17516-7

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

239-51

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(09)17516-7

journal_volume

175

pub_type

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