Consciousness and epilepsy: why are patients with absence seizures absent?

Abstract:

:Epileptic seizures cause dynamic, reversible changes in brain function and are often associated with loss of consciousness. Of all seizure types, absence seizures lead to the most selective deficits in consciousness, with relatively little motor or other manifestations. Impaired consciousness in absence seizures is not monolithic, but varies in severity between patients and even between episodes in the same patient. In addition, some aspects of consciousness may be more severely involved than other aspects. The mechanisms for this variability are not known. Here we review the literature on human absence seizures and discuss a hypothesis for why effects on consciousness may be variable. Based on behavioral studies, electrophysiology, and recent neuroimaging and molecular investigations, we propose absence seizures impair focal, not generalized brain functions. Impaired consciousness in absence seizures may be caused by focal disruption of information processing in specific corticothalamic networks, while other networks are spared. Deficits in selective and varying cognitive functions may lead to impairment in different aspects of consciousness. Further investigations of the relationship between behavior and altered network function in absence seizures may improve our understanding of both normal and impaired consciousness.

journal_name

Prog Brain Res

authors

Blumenfeld H

doi

10.1016/S0079-6123(05)50020-7

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

271-86

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(05)50020-7

journal_volume

150

pub_type

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