Vestibular heading perception in Parkinson's disease.

Abstract:

:Postural instability and falls are common causes of morbidity and mortality in the second most prevalent neurodegenerative condition, Parkinson's disease (PD). Poor understanding of balance dysfunction in PD has hampered the development of novel therapeutic measures for postural instability and balance dysfunction. We aimed to determine how the ability to perceive one's own linear motion in the absence of visual cues, i.e., vestibular heading, is affected in PD. We examined vestibular heading function using a two-alternative forced choice task performed on a six-degree-of-freedom motion platform. Sensitivity of the vestibular system to subtle variations in heading direction and systematic errors in accuracy of responses were assessed for each subject using a Gaussian cumulative distribution psychometric function. Compared to healthy subjects, PD presented with higher angular thresholds to detect vestibular heading direction. These results confirm the potential of our study to provide valuable insight to the vestibular system's role in spatial navigation deficits in PD.

journal_name

Prog Brain Res

authors

Beylergil SB,Ozinga S,Walker MF,McIntyre CC,Shaikh AG

doi

10.1016/bs.pbr.2019.03.034

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

307-319

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(19)30064-0

journal_volume

249

pub_type

杂志文章
  • Functional genomics of sex hormone-dependent neuroendocrine systems: specific and generalized actions in the CNS.

    abstract::Sex hormone effects on hypothalamic neurons have been worked out to a point where receptor mechanisms are relatively well understood, a neural circuit for a sex steroid-dependent behavior has been determined, and several functional genomic regulations have been discovered and conceptualized. With that knowledge in han...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)58012-4

    authors: Lee AW,Devidze N,Pfaff DW,Zhou J

    更新日期:2006-01-01 00:00:00

  • The psychosocial development of world-class athletes: Additional considerations for understanding the whole person and salience of adversity.

    abstract::In the target article, Hardy and colleagues provided an incisive analysis of retrospectively reported psychosocial factors associated with the development and careers of 32 former athletes from Olympic sports. They found that Super-Elite athletes ("serial" medal winners at major international championships, i.e., Worl...

    journal_title:Progress in brain research

    pub_type: 评论,杂志文章

    doi:10.1016/bs.pbr.2016.11.006

    authors: Gucciardi DF

    更新日期:2017-01-01 00:00:00

  • NGF deprivation-induced gene expression: after ten years, where do we stand?

    abstract::Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over th...

    journal_title:Progress in brain research

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/S0079-6123(03)46008-1

    authors: Freeman RS,Burch RL,Crowder RJ,Lomb DJ,Schoell MC,Straub JA,Xie L

    更新日期:2004-01-01 00:00:00

  • The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus.

    abstract::Chronic epilepsy, as a consequence of status epilepticus, has been studied in animal models in order to analyze the cellular mechanisms responsible for the subsequent occurrence of spontaneous seizures. Status epilepticus, induced by either kainic acid or pilocarpine or by prolonged electrical stimulation, causes a ch...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(02)35007-6

    authors: Dudek FE,Hellier JL,Williams PA,Ferraro DJ,Staley KJ

    更新日期:2002-01-01 00:00:00

  • Vestibular control of skeletal geometry in the guinea pig: a problem of good trim?

    abstract::Motor control of different segments of the body with multiple degrees of freedom appears to be coordinated by utilizing preferred axes of motor activity. This hypothesis may also be applied to vestibular control of posture. To explore this question we studied the anatomical relationship between the head and the cervic...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/s0079-6123(08)62282-7

    authors: Vidal PP,Wang DH,Graf W,de Waele C

    更新日期:1993-01-01 00:00:00

  • Applying saccade models to account for oscillations.

    abstract::Saccadic oscillations are unwanted back-to-back saccades occurring one upon the other that produce a high-frequency oscillation of the eyes (usually 15-30 Hz). These may occur transiently in normal subjects, for example, around the orthogonal axis of a purely horizontal or vertical saccade, during combined saccade-ver...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(08)00616-X

    authors: Ramat S,Leigh RJ,Zee DS,Shaikh AG,Optican LM

    更新日期:2008-01-01 00:00:00

  • The molecular biology of human hereditary central diabetes insipidus.

    abstract::Molecular biology techniques have begun to shed light on the genetic basis of autosomal dominant central DI, but several very basic questions remain to be answered. The disorder was initially presumed to have a developmental, degenerative, or autoimmune basis based on the autopsy findings in the hypothalamus of a limi...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)64580-x

    authors: Repaske DR,Phillips JA 3rd

    更新日期:1992-01-01 00:00:00

  • Circannual rhythm in the varied carpet beetle, Anthrenus verbasci.

    abstract::Although circannual rhythms controlling different physiological processes and various aspects of behavior have been reported in numerous organisms, our understanding of the underlying biological mechanisms is still quite limited. We examined the mechanisms controlling the circannual pupation rhythm of the varied carpe...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-59427-3.00025-3

    authors: Miyazaki Y,Nisimura T,Numata H

    更新日期:2012-01-01 00:00:00

  • Intrathecal administration of GABA agonists in the vegetative state.

    abstract::Gamma aminobutyric acid (GABA) is an inhibitor neurotransmitter that plays many important roles in the central nervous system. Because the half-life time of GABA is very short in vivo, GABA itself is not used for clinical practice. An analogue of GABA, baclofen, is an agonist of GABA-B receptor, and has very strong an...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(09)17721-X

    authors: Taira T

    更新日期:2009-01-01 00:00:00

  • Event-related potential measures of consciousness: two equations with three unknowns.

    abstract::This is a brief review of event-related brain potentials (ERPs) as indices of cortical information processing in conditions in which conscious perception of stimuli is supposed to be absent: sleep, coma, vegetative state, general anesthesia, neglect as well as presentation of subliminal or masked stimuli. Exogenous ER...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(05)50030-X

    authors: Kotchoubey B

    更新日期:2005-01-01 00:00:00

  • Plasticity in brain processing and modulation of pain.

    abstract::Brain processing of pain in humans is based on multiple ascending pathways and brain regions that are involved in several pain components, such as sensory, immediate affective, and secondary affective dimensions. These dimensions are processed both serially and in parallel. They include spinal ascending pathways that ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(06)57020-7

    authors: Price DD,Verne GN,Schwartz JM

    更新日期:2006-01-01 00:00:00

  • Distributed processing in the motor system: spinal cord perspective.

    abstract::Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(01)30018-3

    authors: Prut Y,Perlmutter SI,Fetz EE

    更新日期:2001-01-01 00:00:00

  • ECM in brain aging and dementia.

    abstract::An essential component of the brain extracellular space is the extracellular matrix contributing to the spatial assembly of cells by binding cell-surface adhesion molecules, supporting cell migration, differentiation, and tissue development. The most interesting and complex functions of the central nervous system are ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-63486-3.00010-4

    authors: Morawski M,Filippov M,Tzinia A,Tsilibary E,Vargova L

    更新日期:2014-01-01 00:00:00

  • The resonant system: Linking brain-body-environment in sport performance☆.

    abstract::The ecological dynamics approach offers new insights to understand how athlete nervous systems are embedded within the body-environment system in sport. Cognitive neuroscience focuses on the neural bases of athlete behaviors in terms of perceptual, cognitive, and motor functions defined within specific brain structure...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2017.06.001

    authors: Teques P,Araújo D,Seifert L,Del Campo VL,Davids K

    更新日期:2017-01-01 00:00:00

  • Physiological properties and afferent connections of the locus coeruleus and adjacent tegmental neurons involved in the generation of paradoxical sleep in the cat.

    abstract::Results reported here confirm and extend those of early retrograde transport studies of the brainstem in the rat and cat. This study demonstrates substantial and multiple afferent projections to the cat locus coeruleus arising from neurons containing acetylcholine, serotonin, norepinephrine, epinephrine, dopamine, his...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63798-x

    authors: Sakai K

    更新日期:1991-01-01 00:00:00

  • Neuroendocrine dysregulations in sexually abused children and adolescents: a systematic review.

    abstract::Several studies provided evidence for neuroendocrine dysregulations in adults with a history of child sexual abuse. This review focuses on neuroendocrine studies in sexually abused children and adolescents, dating from January 1, 1990 to January 1, 2007 and obtained from a systematic Medline Indexed literature search ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,meta分析

    doi:10.1016/S0079-6123(07)67028-9

    authors: Bicanic IA,Meijer M,Sinnema G,van de Putte EM,Olff M

    更新日期:2008-01-01 00:00:00

  • Changing health behavior motivation from I-must to I-want.

    abstract::In the past, medicine was dominated by acute diseases. Since treatments were unknown to patients they followed their medical doctors´ directives-at least for the duration of the disease. Behavior was thus largely motivated by avoiding expected costs associated with alternative behaviors (I-must). The health challenges...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/bs.pbr.2016.06.013

    authors: Knecht S,Kenning P

    更新日期:2016-01-01 00:00:00

  • Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse.

    abstract::The serotonin (5-HT) neurotransmitter system provides fundamental modulatory regulation of the limbic-corticostriatal circuitry known to be vital in the development of addiction as well as the aspects of addiction that hinder recovery and contribute to relapse. Thus, components of the 5-HT system may provide novel tar...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(08)00916-3

    authors: Bubar MJ,Cunningham KA

    更新日期:2008-01-01 00:00:00

  • The role of mitochondria and oxidative stress in neuronal damage after brief and prolonged seizures.

    abstract::Studies in vitro and in other disease states where excitotoxicity is believed to be important have demonstrated that mitochondrial function is a critical determinant of cell death, reflecting key roles in intracellular calcium homeostasis, energy production and oxidative stress. Central to this is the process of mitoc...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(02)35018-0

    authors: Cock HR

    更新日期:2002-01-01 00:00:00

  • Somatostatin analogues: treatment of pituitary and neuroendocrine tumors.

    abstract::This chapter summarizes the most recent data on the use of the somatostatin analogues (SSAs), octreotide (OCT) and lanreotide for the treatment of patients with pituitary and neuroendocrine tumors (NETs). These two analogues have a high affinity for somatostatin receptor (SSR) sub-types 2 and 5. The major indications ...

    journal_title:Progress in brain research

    pub_type: 杂志文章

    doi:10.1016/S0079-6123(10)82012-6

    authors: Colao A,Faggiano A,Pivonello R

    更新日期:2010-01-01 00:00:00

  • The effects of surgery and anesthesia on memory and cognition.

    abstract::This chapter describes current findings from the research into postoperative cognitive dysfunction (POCD) following cardiac and non-cardiac surgery in older adults. The evidence suggests that a significant proportion of patients show POCD in the early weeks following surgery and anesthesia. Specific domains of cogniti...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)00026-X

    authors: Caza N,Taha R,Qi Y,Blaise G

    更新日期:2008-01-01 00:00:00

  • Some organizing principles for the control of movement based on olivocerebellar physiology.

    abstract::Motor control is defined as the process of restricting the output of the motor nervous system so that meaningful and coordinated behavior ensues. The high dimensionality of the computation underlying motor control is presented and a simplifying framework is outlined. Evidence that movements are performed non-continuou...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)63380-4

    authors: Welsh JP,Llinás R

    更新日期:1997-01-01 00:00:00

  • Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives.

    abstract::Selective neuronal loss following status epilepticus was first described just under 100 years ago. The acute pathology following status epilepticus was shown to be 'ischemic cell change' and was assumed to arise through hypoxia/ischemia. Less than 30 years ago it was proposed, from experiments in primates, that the se...

    journal_title:Progress in brain research

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/S0079-6123(02)35003-9

    authors: Meldrum BS

    更新日期:2002-01-01 00:00:00

  • When the auditory cortex turns visual.

    abstract::We studied visually guided behavior and the visual response properties of single auditory cortex (A1) neurons in neonatally operated hamsters with surgically induced, permanent, ectopic retinal projections to auditory thalamic nuclei and to visual thalamic nuclei which normally receive little direct retinal input. The...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(01)34029-3

    authors: Ptito M,Giguère JF,Boire D,Frost DO,Casanova C

    更新日期:2001-01-01 00:00:00

  • Development of brain mechanisms for visual global processing and object segmentation.

    abstract::Objects have specific cognitive attributes, elicit particular visuo-motor responses, and require visual processes beyond primary visual cortex to combine information over extended regions as a basis for the segmentation and integration of visual objects. As well as segmentation, the assignment of region boundaries to ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(07)64008-4

    authors: Braddick O,Atkinson J

    更新日期:2007-01-01 00:00:00

  • Astroglia: important mediators of traumatic brain injury.

    abstract::Traumatic brain injury (TBI) research to date has focused almost exclusively on the pathophysiology of injured neurons with very little attention paid to non-neuronal cells. However in the past decade, exciting discoveries have challenged this century-old view of passive glial cells and have led to a reinterpretation ...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/S0079-6123(06)61005-4

    authors: Floyd CL,Lyeth BG

    更新日期:2007-01-01 00:00:00

  • Reduced neuronal activity and reactivation in Alzheimer's disease.

    abstract::1. Alzheimer's disease is a multifactorial disease in which age and APOE-epsilon 4 are important risk factors. Various mutations and even viral infections such as herpes simplex (Itzhaki et al., 1997) may play an additional role. 2. The neuropathological hallmarks of Alzheimer's disease (AD), i.e. amorphous plaques, n...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0079-6123(08)64027-3

    authors: Swaab DF,Lucassen PJ,Salehi A,Scherder EJ,van Someren EJ,Verwer RW

    更新日期:1998-01-01 00:00:00

  • Emotion regulation and emotion perception in aging: A perspective on age-related differences and similarities.

    abstract::The aim of this chapter is to review recent literature describing how developments in cognition may contribute to age-related changes in emotional processes, specifically emotion regulation and emotion perception. In general, older adults are more likely than young adults to report feeling positive. Prominent conceptu...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/bs.pbr.2019.02.007

    authors: Gurera JW,Isaacowitz DM

    更新日期:2019-01-01 00:00:00

  • Hector Berlioz and his Vesuvius: an analysis of historical evidence from an epileptological perspective.

    abstract::The epileptologically informed in-depth analysis of auto- and heteroanamnestic historical sources supports the hypothesis that Hector Berlioz (1803-1869) might have suffered from a photosensitive idiopathic generalized epilepsy syndrome with absences, absence status, myoclonic seizures, and bilateral tonic-clonic seiz...

    journal_title:Progress in brain research

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/bs.pbr.2014.11.007

    authors: Altenmüller DM

    更新日期:2015-01-01 00:00:00

  • In vivo imaging of the integration and function of nigral grafts in clinical trials.

    abstract::In vivo functional imaging has provided objective evidence for the integration and function of nigral grafts in the brains of patients with Parkinson's disease. Clinical trials with the use of positron emission tomography have shown that transplants of human dopamine-rich fetal ventral mesencephalic tissue can survive...

    journal_title:Progress in brain research

    pub_type: 杂志文章,评审

    doi:10.1016/B978-0-444-59575-1.00009-0

    authors: Politis M,Piccini P

    更新日期:2012-01-01 00:00:00