Abstract:
:Postural instability and falls are common causes of morbidity and mortality in the second most prevalent neurodegenerative condition, Parkinson's disease (PD). Poor understanding of balance dysfunction in PD has hampered the development of novel therapeutic measures for postural instability and balance dysfunction. We aimed to determine how the ability to perceive one's own linear motion in the absence of visual cues, i.e., vestibular heading, is affected in PD. We examined vestibular heading function using a two-alternative forced choice task performed on a six-degree-of-freedom motion platform. Sensitivity of the vestibular system to subtle variations in heading direction and systematic errors in accuracy of responses were assessed for each subject using a Gaussian cumulative distribution psychometric function. Compared to healthy subjects, PD presented with higher angular thresholds to detect vestibular heading direction. These results confirm the potential of our study to provide valuable insight to the vestibular system's role in spatial navigation deficits in PD.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Beylergil SB,Ozinga S,Walker MF,McIntyre CC,Shaikh AGdoi
10.1016/bs.pbr.2019.03.034subject
Has Abstractpub_date
2019-01-01 00:00:00pages
307-319eissn
0079-6123issn
1875-7855pii
S0079-6123(19)30064-0journal_volume
249pub_type
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