Vestibular heading perception in Parkinson's disease.

Abstract:

:Postural instability and falls are common causes of morbidity and mortality in the second most prevalent neurodegenerative condition, Parkinson's disease (PD). Poor understanding of balance dysfunction in PD has hampered the development of novel therapeutic measures for postural instability and balance dysfunction. We aimed to determine how the ability to perceive one's own linear motion in the absence of visual cues, i.e., vestibular heading, is affected in PD. We examined vestibular heading function using a two-alternative forced choice task performed on a six-degree-of-freedom motion platform. Sensitivity of the vestibular system to subtle variations in heading direction and systematic errors in accuracy of responses were assessed for each subject using a Gaussian cumulative distribution psychometric function. Compared to healthy subjects, PD presented with higher angular thresholds to detect vestibular heading direction. These results confirm the potential of our study to provide valuable insight to the vestibular system's role in spatial navigation deficits in PD.

journal_name

Prog Brain Res

authors

Beylergil SB,Ozinga S,Walker MF,McIntyre CC,Shaikh AG

doi

10.1016/bs.pbr.2019.03.034

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

307-319

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(19)30064-0

journal_volume

249

pub_type

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