Abstract:
:Three rhythmic movements, breathing, walking, and chewing, are considered from the perspective of the emerging factors that control their coordination. This takes us beyond the concept of a core excitatory kernel and into the common principles that govern the interaction between components of the neural networks that must be orchestrated properly to produce meaningful movement beyond the production of the basic rhythm. We focus on the role of neuromodulators, especially 5-hydroxytryptamine (5-HT), in the production of coordinated breathing, walking, and chewing, and we review the evidence that at least in the case of breathing and walking, 5-HT input to the CPGs acts through the selection of inhibitory interneurons that are essential for coordination. We review data from recently developed mouse models that offer insight into the contributions of inhibitory coordinating neurons, including the development of a new model that has allowed the revelation that there are glycinergic pacemaker neurons that likely contribute to the production of the respiratory rhythm. Perhaps walking and chewing will not be far behind.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Jordan LM,Sławińska Udoi
10.1016/B978-0-444-53825-3.00017-6subject
Has Abstractpub_date
2011-01-01 00:00:00pages
181-95eissn
0079-6123issn
1875-7855pii
B978-0-444-53825-3.00017-6journal_volume
188pub_type
杂志文章,评审abstract::This chapter has highlighted how correlates of neuronal plasticity such as electrophysiological responsiveness and changes in gene expression may be examined in defined CNS regions as well as in single cells. The ability to simultaneously measure the mRNA levels for hundreds of different genes, to clone novel genes, a...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63289-6
更新日期:1995-01-01 00:00:00
abstract::Artistic ability and creativity are defining characteristics of human behavior. Behavioral neurology, as a specialty, believes that even the most complex behaviors can be modeled and understood as the summation of smaller cognitive functions. Literature from individuals with specific brain lesions has helped to map ou...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-63287-6.00005-1
更新日期:2013-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)54009-9
更新日期:2006-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-59426-6.00003-3
更新日期:2012-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::Concerted efforts are realizing cell-based therapy for Parkinson's disease (PD). In this chapter, I describe efforts at the Center for iPS Cell Research and Application (CiRA), Kyoto University. These efforts use induced pluripotent stem cells (iPSCs) as donor cells. The iPSCs were established as human leukocyte antig...
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pub_type: 杂志文章
doi:10.1016/bs.pbr.2016.11.004
更新日期:2017-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00626-2
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/bs.pbr.2017.05.004
更新日期:2017-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00404-4
更新日期:2008-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)33014-5
更新日期:2001-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53839-0.00009-0
更新日期:2011-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(01)30018-3
更新日期:2001-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2015.07.026
更新日期:2016-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)43025-2
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)56019-4
更新日期:2006-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63829-7
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)67008-3
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)50010-4
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Primary angle-closure glaucoma (PACG) is the leading cause of blindness in East Asia. The disease can be classified into primary angle-closure suspect, primary angle closure (PAC), and PACG. Pupil-block, anterior nonpupil-block (plateau iris and peripheral iris crowding), lens related and retrolenticular m...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)01104-7
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53702-7.00001-4
更新日期:2010-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most prevalent form of neurodegeneration; however, therapies to prevent or treat AD are inadequate. Amyloid-beta (Abeta) protein accrues in cortical senile plaques, one of the key neuropathological hallmarks of AD, and is elevated in brains of early onset AD patients in a small number o...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61801-4
更新日期:1995-01-01 00:00:00
abstract::Glaucoma is a visual disorder characterized by progressive loss of retinal ganglion cells (RGCs), which is often associated with high intraocular pressure. However, mechanisms of RGC death in glaucoma still remain a mystery. Two theories have been proposed as pathogeneses of glaucoma: mechanical and vascular. We demon...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)01134-5
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00666-3
更新日期:2008-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
abstract::Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over th...
journal_title:Progress in brain research
pub_type: 历史文章,杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)48015-7
更新日期:2005-01-01 00:00:00