Abstract:
:Intron-specific probes measure heteronuclear RNA (hnRNA) levels and thus approximate the transcription rates of genes, in part because of the rapid turnover of this intermediate form of RNA in the cell nucleus. Previously, we used oxytocin (Oxt)- and vasopressin (Avp)- intron-specific riboprobes to measure changes in Oxt and Avp hnRNA levels in the supraoptic nucleus (SON) by quantitative in situ hybridization (ISH) after various classical physiological perturbations, including acute and chronic salt loading, and lactation. In the present experiments, we used a novel experimental model to study the neurotransmitter regulation of Oxt and Avp gene expression in the rat SON in vivo. Bilateral cannulae connected via tubing to Alzet osmotic mini-pumps were positioned over the SON. In every experiment, one SON was infused with PBS and served as the control SON in each animal, and the contralateral SON received infusions of various neurotransmitter agonists and antagonists. Using this approach, we found that Avp but not Oxt gene expression increased after acute (2-5h) combined excitatory amino acid agonist and GABA antagonist treatment, similar to what we found after an acute hyperosmotic stimulus. Since both OXT and AVP are known to be comparably and robustly secreted in response to acute osmotic stimuli in vivo and glutamate agonists in vitro, our results indicate a dissociation between OXT secretion and Oxt gene transcription in vivo.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Scordalakes EM,Yue C,Gainer Hdoi
10.1016/S0079-6123(08)00404-4subject
Has Abstractpub_date
2008-01-01 00:00:00pages
43-51eissn
0079-6123issn
1875-7855pii
S0079-6123(08)00404-4journal_volume
170pub_type
杂志文章abstract::The two roles in awareness most often suggested for the cerebellum are (i) keeping the details of motor skills away from forebrain computation, and (ii) signaling to the forebrain when a sensory event is not predictable from prior motor commands. However, it is unclear how current models of the cerebellum could carry ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(03)14404-4
更新日期:2004-01-01 00:00:00
abstract::In the kidney, the actions of the antidiuretic hormone arginine vasopressin (AVP) renders the collecting duct highly permeable to water. This large increase in water permeability is largely due to the translocation of the water channel aquaporin-2 (AQP-2) from intracellular storage vesicles to the apical plasma membra...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(08)00444-5
更新日期:2008-01-01 00:00:00
abstract::Vasopressin (VP) is one of the principal neurotransmitters of the suprachiasmatic nucleus (SCN). By means of anatomical, physiological and electrophysiological techniques we have demonstrated that VP containing pathways from the SCN serve to affect neuroendocrine and 'autonomic' neurons in the paraventricular nucleus....
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)61581-2
更新日期:1998-01-01 00:00:00
abstract::Susceptibility to chronic tinnitus is highly variable and of particular interest when it comes to defining strategies for prevention and treatment. While several rare monogenic disorders have been described that are associated with tinnitus, the genetic underpinnings of the more common forms of the syndrome are still ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(07)66014-2
更新日期:2007-01-01 00:00:00
abstract::Motor control is defined as the process of restricting the output of the motor nervous system so that meaningful and coordinated behavior ensues. The high dimensionality of the computation underlying motor control is presented and a simplifying framework is outlined. Evidence that movements are performed non-continuou...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63380-4
更新日期:1997-01-01 00:00:00
abstract::We developed a theoretical framework for studying coordination strategies in standing posture. The framework consists of a musculoskeletal model of the human lower extremity in the sagittal plane and a technique to visualize, geometrically, how constraints internal and external to the body affect movement. The set of ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62294-3
更新日期:1993-01-01 00:00:00
abstract::By blocking electrical activity in the cerebellar cortex the Purkinje cell dendrites become a uniform territory with a high density of spines all bearing the glutamate receptor delta2 subunit (GluRdelta2) and being mainly innervated by parallel fibers. Such a subunit, which is constitutively targeted specifically to t...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(04)48005-4
更新日期:2005-01-01 00:00:00
abstract::Neuroimaging studies of major depression have identified neurophysiological abnormalities in multiple areas of the prefrontal cortex (PFC), the amygdala, and related parts of the striatum and thalamus. Some of these abnormalities are mood state-dependent, and appear in regions where cerebral blood flow (CBF) increases...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(00)26027-5
更新日期:2000-01-01 00:00:00
abstract::There is increasing evidence that human cognitive functions can be addressed from a robust neuroscience perspective. In particular, the distributed coherent electrical properties of central neuronal ensembles are considered to be a promising avenue of inquiry concerning global brain functions. The intrinsic oscillator...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)50010-4
更新日期:2005-01-01 00:00:00
abstract::The recent increase in the frequency and intensity of killer heat waves across the globe has aroused worldwide medical attention to exploring therapeutic strategies to attenuate heat-related morbidity and/or mortality. Death due to heat-related illnesses often exceeds >50% of heat victims. Those who survive are crippl...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)62010-4
更新日期:2007-01-01 00:00:00
abstract::In the present contribution, the various functional interpretations concerning the putative function of the orbital prefrontal cortex are reviewed since this region and adjacent areas are considered the neural substrate of social behavior in general, and decision-making behavior in particular. This literature review r...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(09)01306-5
更新日期:2009-01-01 00:00:00
abstract::The receptor tyrosine kinase B, TrkB, is the high-affinity receptor for brain-derived neurotrophic factor (BDNF). Much evidence supports a role for TrkB signaling in excitatory synapse formation. There have been a number of recent advances in understanding the cell biology of TrkB-mediated excitatory synaptogenesis. T...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(06)57002-5
更新日期:2006-01-01 00:00:00
abstract::Normal brain function requires constant adaptation as an organism interacts with the environment and learns to associate important sensory stimuli with appropriate motor actions. Neurological disorders may disrupt these learned associations, potentially requiring new functional pathways to be formed to replace the los...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/B978-0-444-53355-5.00006-3
更新日期:2011-01-01 00:00:00
abstract::Nitric oxide (NO) is widespread in the nervous system and is thought to play a role in a variety of different neuronal functions, including learning and memory (see other chapters, this volume). A number of behavioral studies have indicated that NO is involved in several types of learning such as motor learning (Yanag...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/s0079-6123(08)63206-9
更新日期:1998-01-01 00:00:00
abstract::Life expectancies have increased substantially in the last century, dramatically amplifying the proportion of individuals who will reach old age. As individuals age, cognitive ability declines, although the rate of decline differs amongst the forms of memory domains and for different individuals. Memory domains especi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(10)82002-3
更新日期:2010-01-01 00:00:00
abstract::Variation in neocortex size is one of the defining features of mammalian brain evolution. The paramount assumption has been that neocortex size indicates a monotonic allometric relationship with brain size. This assumption holds the concomitant neurodevelopmental assumption that the ontogenetic trajectory of neocortex...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2019.05.002
更新日期:2019-01-01 00:00:00
abstract::The identification of several mutations causing familial forms of Parkinson's disease (PD) has led to the creation of multiple lines of mice expressing similar genetic alterations. These models present a unique opportunity for understanding pathophysiological mechanisms leading to PD in a mammalian brain and provide m...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(10)84004-X
更新日期:2010-01-01 00:00:00
abstract::The management of urinary tract dysfunction is crucial for the health and well-being of people with spinal cord injury. Devices, specifically catheters, play an important role in the daily regime of bladder management for most people with spinal cord injury. However, the high incidence of complications associated with...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)52011-9
更新日期:2006-01-01 00:00:00
abstract::The ability to form tenable hypotheses regarding the neurobiological basis of normative functions as well as mechanisms underlying neurodegenerative and neuropsychiatric disorders is often limited by the highly complex brain circuitry and the cellular and molecular mosaics therein. The brain is an intricate structure ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)58002-1
更新日期:2006-01-01 00:00:00
abstract::This is a brief review of event-related brain potentials (ERPs) as indices of cortical information processing in conditions in which conscious perception of stimuli is supposed to be absent: sleep, coma, vegetative state, general anesthesia, neglect as well as presentation of subliminal or masked stimuli. Exogenous ER...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)50030-X
更新日期:2005-01-01 00:00:00
abstract::Recent years have brought a rapid growth in knowledge of the prodromal phase of Parkinson's disease (PD). It is now clear that the clinical phase of PD is preceded by a phase of progressing neurodegeneration lasting many years. This involves not only central nervous system structures outside the substantia nigra and n...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2020.01.003
更新日期:2020-01-01 00:00:00
abstract::Treatment of refractory PD with autologous adrenal medullary implants utilizing two-stage surgery warrants further investigation. This transplantation technique is associated with prolonged transplant area BBB disruption which may require a change in medical treatment strategies including the withdrawal of peripheral ...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)62658-8
更新日期:1990-01-01 00:00:00
abstract::What are the building blocks of our visual representations? Whatever we look at, the things we see will have some feature variability: even snow is not purely white but has a range of shades of white. However, in most studies investigating visual perception, homogeneous displays with all stimuli having a very limited ...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/bs.pbr.2017.07.001
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Primary angle-closure glaucoma (PACG) is the leading cause of blindness in East Asia. The disease can be classified into primary angle-closure suspect, primary angle closure (PAC), and PACG. Pupil-block, anterior nonpupil-block (plateau iris and peripheral iris crowding), lens related and retrolenticular m...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)01104-7
更新日期:2008-01-01 00:00:00
abstract::More than a decade ago, Goodale and Milner proposed that our perceptual experience of the world depends on visual processing that is fundamentally distinct from that mediating the moment-to-moment visual control of our actions. They mapped this distinction between vision-for-perception and vision-for-action onto the t...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(05)49019-6
更新日期:2005-01-01 00:00:00
abstract::Children with epilepsy are known to have high rates of mental health problems. The role of seizures in the development of these problems is not known primarily because of difficulties in separating the effects of seizures from the three other potential causal factors: (a) poor child and family response to the conditio...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)35039-8
更新日期:2002-01-01 00:00:00
abstract::The results from the language studies taken as a whole point to different developmental time courses and developmental vulnerabilities of aspects of grammatical and semantic/lexical processing. They thus provide support for conceptions of language that distinguish these subprocesses within language. Similarly, followi...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(02)38078-6
更新日期:2002-01-01 00:00:00
abstract::Object recognition and visual attention are tightly linked processes in human perception. Over the last three decades, many models have been suggested to explain these two processes and their interactions, and in some cases these models appear to contradict each other. We suggest a unifying framework for object recogn...
journal_title:Progress in brain research
pub_type: 杂志文章,评审
doi:10.1016/S0079-6123(06)65005-X
更新日期:2007-01-01 00:00:00
abstract::The role of the vesitibulo-cerebellum of the rabbit in the control of the vestibulo-ocular response (VOR) and optokinetic response (OKR) reflexes was investigated by bilateral microinjections, into the flocculus, of substances affecting GABAergic or noradrenergic neurotransmission. GABA, the main transmitter through w...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/s0079-6123(08)63829-7
更新日期:1991-01-01 00:00:00
abstract::Human and nonhuman primates predictively use smooth pursuit and saccades to track visual targets that move in a fronto-parallel plane. This behaviour is believed to be facilitated by short-term memory of the target motion and/or an efference copy of the subject's motor effort. Subjects in our experiments tracked dicho...
journal_title:Progress in brain research
pub_type: 杂志文章
doi:10.1016/S0079-6123(08)00666-3
更新日期:2008-01-01 00:00:00