Functional genomic methodologies.

abstract：:The febrile reaction is an integrated endocrine, autonomic and behavioral response, coordinated by the hypothalamus, that includes certain components of the stress response, such as elevated corticosteroid secretion. It is produced by the actions of circulating cytokines, such as interleukin-1 (IL-1) and tumor necrosi...

journal_title：Progress in brain research

authors： Saper CB,Breder CD

更新日期：1992-01-01 00:00:00

abstract：:Primates are endowed with a brain about twice the size that of a mammal with the same body size, and humans have the largest brain relative to body size of all animals. This increase in brain size may be related to the acquisition of higher cognitive skills that permitted more complex social interactions, the evolutio...

journal_title：Progress in brain research

authors： Aboitiz F,Montiel JF

更新日期：2012-01-01 00:00:00

abstract：:The quantitative autoradiographic method with L-(35S)methionine was applied to investigate the effect of chronic dehydration on rates of protein synthesis in circumventricular organs (CVOs). Water deprivation for 1, 2 and 3 days causes progressive increases of protein synthesis in the subfornical organ (SFO), the area...

journal_title：Progress in brain research

authors： Lepetit P,Grange E,Gay N,Bobillier P

更新日期：1992-01-01 00:00:00

abstract：:Glial scar encapsulation is thought to be one of the major reasons for the failure of chronic brain-machine interfaces. Many strategies, including modification of the probe surface chemistry, delivery of anti-inflammatory drugs, and changes of probe geometry, have been employed to reduce glial scar formation. We have ...

journal_title：Progress in brain research

authors： Ouyang L,Green R,Feldman KE,Martin DC

更新日期：2011-01-01 00:00:00

abstract：:Large-scale neural simulations have the marks of a distinct methodology which can be fruitfully deployed in neuroscience. I distinguish between two types of applications of the simulation methodology in neuroscientific research. Model-oriented applications aim to use the simulation outputs to derive new hypotheses abo...

journal_title：Progress in brain research

authors： Serban M

更新日期：2017-01-01 00:00:00

abstract：:The role of the vesitibulo-cerebellum of the rabbit in the control of the vestibulo-ocular response (VOR) and optokinetic response (OKR) reflexes was investigated by bilateral microinjections, into the flocculus, of substances affecting GABAergic or noradrenergic neurotransmission. GABA, the main transmitter through w...

journal_title：Progress in brain research

authors： van Neerven J,Pompeiano O,Collewijn H

更新日期：1991-01-01 00:00:00

abstract：:Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over th...

journal_title：Progress in brain research

authors： Freeman RS,Burch RL,Crowder RJ,Lomb DJ,Schoell MC,Straub JA,Xie L

更新日期：2004-01-01 00:00:00

abstract：:Two cortical areas that crucially contribute to the generation and maintenance of smooth pursuit eye movements (SPEM) are the medial superior temporal area (MST) and the pursuit area of the frontal eye fields (FEF). They both project to the brainstem premotor structures via different parallel pathways. A special prope...

journal_title：Progress in brain research

authors： Nuding U,Ono S,Mustari MJ,Büttner U,Glasauer S

更新日期：2008-01-01 00:00:00

abstract：:Basic tendencies to detect and respond to significant events are present in the simplest single cell organisms and persist throughout all invertebrates and vertebrates. Within vertebrates, the overall brain plan is highly conserved, though differences in size and complexity also exist. The forebrain differs the most b...

journal_title：Progress in brain research

authors： LeDoux JE

更新日期：2012-01-01 00:00:00

abstract：:What are the building blocks of our visual representations? Whatever we look at, the things we see will have some feature variability: even snow is not purely white but has a range of shades of white. However, in most studies investigating visual perception, homogeneous displays with all stimuli having a very limited ...

journal_title：Progress in brain research

authors： Chetverikov A,Campana G,Kristjánsson Á

更新日期：2017-01-01 00:00:00

abstract：:Neuronal activity increases synthesis of brain-derived neurotrophic factor (BDNF) mRNA in vivo and in vitro. We have investigated the pathways through which neuronal activity stimulated by kainic acid regulates BDNF mRNA levels in cultured hippocampal neurons and transgenic mice. Kainic acid induced the transcription ...

journal_title：Progress in brain research

authors： Castrén E,Berninger B,Leingärtner A,Lindholm D

更新日期：1998-01-01 00:00:00

abstract：:Neural transplantation has emerged as a possible therapy for Parkinson's disease (PD). Clinical studies performed during the 1990s, where dopaminergic neurons derived from the human embryonic brain were transplanted into striatum of patients with PD, provided proof-of-principle that long-lasting therapeutic benefits c...

journal_title：Progress in brain research

authors： Brundin P,Barker RA,Parmar M

更新日期：2010-01-01 00:00:00

abstract：:This investigation was designed to study the role of muscarinic receptor subtypes in the cardiovascular responses elicited by microinjection of cholinergic agonists in the intermediate portion of the NTS, the VLPA and VLDA areas and the IML of the spinal cord. Microinjections of L-glutamate (1.77 nmol in 20-50 nl in 0...

journal_title：Progress in brain research

authors： Sapru HN

更新日期：1989-01-01 00:00:00

abstract：:Gamma aminobutyric acid (GABA) is an inhibitor neurotransmitter that plays many important roles in the central nervous system. Because the half-life time of GABA is very short in vivo, GABA itself is not used for clinical practice. An analogue of GABA, baclofen, is an agonist of GABA-B receptor, and has very strong an...

journal_title：Progress in brain research

authors： Taira T

更新日期：2009-01-01 00:00:00

abstract：:Acute spinal cord injury (SCI) is a devastating neurological disorder that can affect any individual at a given instance. Current treatment options for SCI include the use of high dose methylprednisolone sodium succinate, a corticosteroid, surgical interventions to stabilize and decompress the spinal cord, intensive m...

journal_title：Progress in brain research

authors： Baptiste DC,Fehlings MG

更新日期：2007-01-01 00:00:00

abstract：:In order to study cerebral activity related to preparation and execution of movement, evoked and induced brain electrical activities were compared to each other and to fMRI results in voluntary self-paced movements. Also, the event-related desynchronization and synchronization (ERD/ERS) were studied in complex movemen...

journal_title：Progress in brain research

authors： Rektor I,Sochůrková D,Bocková M

更新日期：2006-01-01 00:00:00

abstract：:Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending (sensory) pathways and descending (motor) nerve pathways without the perspective of complete functional recovery. Future spinal cord repair strategies should comprise a multi-factorial approach addressing several issues, includin...

journal_title：Progress in brain research

authors： Hendriks WT,Ruitenberg MJ,Blits B,Boer GJ,Verhaagen J

更新日期：2004-01-01 00:00:00

abstract：:Although circannual rhythms controlling different physiological processes and various aspects of behavior have been reported in numerous organisms, our understanding of the underlying biological mechanisms is still quite limited. We examined the mechanisms controlling the circannual pupation rhythm of the varied carpe...

journal_title：Progress in brain research

authors： Miyazaki Y,Nisimura T,Numata H

更新日期：2012-01-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) participate in a variety of physiologic and pathologic processes in the nervous system. nNOS was originally felt to be a constitutively expressed enzyme, but recent observations suggest that its levels are dynamically controlled in response to neuronal development, plasticity and ...

journal_title：Progress in brain research

authors： Dawson TM,Sasaki M,Gonzalez-Zulueta M,Dawson VL

更新日期：1998-01-01 00:00:00

abstract：:Network oscillations are proposed to provide the framework for the ongoing neural computations of the brain. Thus, an important aspect of understanding the functional roles of various cell classes in the brain is to understand the relationship of cellular activity to the ongoing oscillations. While many studies have c...

journal_title：Progress in brain research

authors： Henze DA,Buzsáki G

更新日期：2007-01-01 00:00:00

abstract：:While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over ...

journal_title：Progress in brain research

authors： Drew T,Prentice S,Schepens B

更新日期：2004-01-01 00:00:00

abstract：:Hand preference is a sensorimotor skill whose development both reflects and promotes the development of hemispheric lateralization for manual and cognitive functions. Extensive comparative, crosscultural, and paleoanthropological evidence demonstrates the prevalence of limb lateralized preferences across vertebrate sp...

journal_title：Progress in brain research

authors： Michel GF,Babik I,Nelson EL,Campbell JM,Marcinowski EC

更新日期：2018-01-01 00:00:00

abstract：:The noradrenergic (NA) afferent projection to the cerebellar cortex, which originates mainly from the locus coeruleus (LC), may act on the target neurons by utilizing both alpha- and beta-adrenoceptors. Experiments performed in decerebrate cats have shown that unilateral injection into the vermal cortex of the cerebel...

journal_title：Progress in brain research

authors： Andre P,d'Ascanio P,Pompeiano O

更新日期：1991-01-01 00:00:00

abstract：:Recordings of spinal INs during a flexion/extension wrist task with an instructed delay period have shown directly that many spinal neurons modulate their rate during the preparatory period soon after a visual cue. The onset time and the relation between the delay period activity of spinal INs and the ensuing movement...

journal_title：Progress in brain research

authors： Prut Y,Perlmutter SI,Fetz EE

更新日期：2001-01-01 00:00:00

abstract：:Characteristic features of autism include atypical social perception and social-communication skills, and atypical visual attention, alongside rigid and repetitive thinking and behavior. Debate has focused on whether the later emergence of atypical social skills is a consequence of attention problems early in life, or...

journal_title：Progress in brain research

authors： Elsabbagh M,Holmboe K,Gliga T,Mercure E,Hudry K,Charman T,Baron-Cohen S,Bolton P,Johnson MH,BASIS Team.

更新日期：2011-01-01 00:00:00

abstract：:Various growth factors are present in the hippocampal formation and appear responsible for the prominent plasticity of this brain area. Although hormone-like growth-promoting polypeptides are the best known, recent studies emphasize the importance in the growth response of molecules such as laminin proteoglycans, neur...

journal_title：Progress in brain research

authors： Nieto-Sampedro M,Bovolenta P

更新日期：1990-01-01 00:00:00

abstract：:Otoacoustic emissions can be used to study cochlear function in an objective, non-invasive and rapid manner. These and other desirable features of emissions have inspired a significant amount of investigation into the practicalities of utilizing evoked emissions as clinical tests of hearing. Variables which affect the...

journal_title：Progress in brain research

authors： Lonsbury-Martin BL,Whitehead ML,Martin GK

更新日期：1993-01-01 00:00:00

abstract：:Evidence for a non-monosynaptic Ia excitation of wrist flexor and quadriceps motoneurones (MNs) in man has been provided while using two independent methods: construction of post-stimulus time histograms (PSTHs) of voluntarily activated motor units and the spatial facilitation of the H-reflex. This non-monosynaptic Ia...

journal_title：Progress in brain research

authors： Pierrot-Deseilligny E

更新日期：1989-01-01 00:00:00

abstract：:Spinal cord injuries often lead to disorders in the control of autonomic function, including problems with blood pressure regulation, voiding, defecation and reproduction. The root cause of all these problems is the destruction of brain pathways that control spinal autonomic neurons lying caudal to the lesion. Changes...

journal_title：Progress in brain research

authors： Llewellyn-Smith IJ,Weaver LC,Keast JR

更新日期：2006-01-01 00:00:00

abstract：:The data presented in this paper show that the appropriate tools are now available to study the behavior of PLP and DM20 transcripts engineered with either point mutations or deletion of specific domains. Such studies should begin to provide new insights into the functions of PLP and DM20 and their role in relation to...

journal_title：Progress in brain research

authors： Lees MB,Smith FI,Dyer CA,Greer JM,Pakaski M

更新日期：1995-01-01 00:00:00