Cortical and brainstem control of locomotion.

Abstract:

:While a basic locomotor rhythm is centrally generated by spinal circuits, descending pathways are critical for ensuring appropriate anticipatory modifications of gait to accommodate uneven terrain. Neurons in the motor cortex command the changes in muscle activity required to modify limb trajectory when stepping over obstacles. Simultaneously, neurons in the brainstem reticular formation ensure that these modifications are superimposed on an appropriate base of postural support. Recent experiments suggest that the same neurons in the same structures also provide similar information during reaching movements. It is suggested that, during both locomotion and reaching movements, the final expression of descending signals is influenced by the state and excitability of the spinal circuits upon which they impinge.

journal_name

Prog Brain Res

authors

Drew T,Prentice S,Schepens B

doi

10.1016/S0079-6123(03)43025-2

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

251-61

eissn

0079-6123

issn

1875-7855

pii

S0079-6123(03)43025-2

journal_volume

143

pub_type

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