Abstract:
:Glial scar encapsulation is thought to be one of the major reasons for the failure of chronic brain-machine interfaces. Many strategies, including modification of the probe surface chemistry, delivery of anti-inflammatory drugs, and changes of probe geometry, have been employed to reduce glial scar formation. We have proposed that a possible means to establish long-term, reliable communication across the scar is the in situ polymerization of conjugated polymers such as PEDOT in neural tissue. Previously, we exposed entire brain slices to the EDOT monomer. Here, we demonstrate that PEDOT can be polymerized by the direct delivery of EDOT monomer to the reaction site. The monomer was delivered into rat cortex via microcannula and simultaneously electrochemically polymerized within the tissue using a microwire electrode. We found that the resulting PEDOT polymer cloud grew out from the working electrode tip and extended far out into the brain tissue, spanning distances more than 1mm. We also examined the morphology of resulting polymer cloud by optical microscopy.
journal_name
Prog Brain Resjournal_title
Progress in brain researchauthors
Ouyang L,Green R,Feldman KE,Martin DCdoi
10.1016/B978-0-444-53815-4.00001-7subject
Has Abstractpub_date
2011-01-01 00:00:00pages
263-71eissn
0079-6123issn
1875-7855pii
B978-0-444-53815-4.00001-7journal_volume
194pub_type
杂志文章abstract::Migraine is among the most common and disabling neurological diseases in the world. Cortical spreading depression (CSD) is a wave of near-complete depolarization of neurons and glial cells that slowly propagates along the cortex creating the perception of aura. Evidence suggests that CSD can trigger migraine headache....
journal_title:Progress in brain research
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journal_title:Progress in brain research
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journal_title:Progress in brain research
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journal_title:Progress in brain research
pub_type: 杂志文章
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